Press Release 2012

A hybrid porous scaffold with enhanced osteoinductivity has been successfully developed by a collaboration team from Tissue Regeneration Materials Unit, International Center for Materials Nanoarchitectonics of National Institute for Materials Science, Nano Medical Engineering Laboratory of RIKEN and National Research Institute for Child Health and Development. The hybrid scaffold was prepared from a mechanical strong synthetic poly(lactic-co-glycolic acid), collagen and a fusion bone morphogenetic protein-4 composed of an additional collagen-binding domain to mimic the nano- and micro-environment surrounding cells in vivo. The hybrid scaffold showed high osteoinductivity and will be used for regeneration of large bone. The hybridization method can also be used to prepare hybrid porous scaffolds with other cell growth factors for promoted regeneration of other tissues such as cartilage and skin.

Hongxu Lu¹, Naoki Kawazoe¹, Takashi Kitajima², Yuka Myoken³, Masahiro Tomita³, Akihiro Umezawa⁴, Guoping Chen¹*, Yoshihiro Ito²*

1-1 Namiki, Tsukuba, Ibaraki, 305-0044 Japan
Email: Guoping Chen, Ph.D<Guoping.CHENnims.go.jp>
Telephone: +81-29-860-4496