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World’s Highest Magnetic Field* (1,020MHz) NMR developed

Application of High-Temperature Superconductor Was the Key. A Big Step Forward in Accelerating the Development of New Drugs and Materials

National Institute for Materials Science (NIMS)
RIKEN
Kobe Steel, Ltd.
JEOL Ltd.
Japan Science and Technology Agency (JST)

The research team of NIMS, RIKEN, Kobe Steel and JEOL RESONANCE successfully developed the NMR system equipped with world’s highest magnetic field, 1,020 MHz, supported by the JST-SENTAN program “Development of Systems and Technology for Advanced Measurement and Analysis”. This research result was published in Journal of Magnetic Resonance on 15 May 2015 (Kenjiro Hashi, Shinobu Ohki, Shinji Matsumoto, Gen Nishijima, Atsushi Goto, Kenzo Deguchi, Kazuhiko Yamada, Takashi Noguchi, Shuji Sakai, Masato Takahashi, Yoshinori Yanagisawa, Seiya Iguchi, Toshio Yamazaki, Hideaki Maeda, Ryoji Tanaka, Takahiro Nemoto, Hiroto Suematsu, Takashi Miki, Kazuyoshi Saito and Tadashi Shimizu, Title:”Achievement of 1,020 MHz NMR”, DOI:10.1016/j.jmr.2015.04.009).

Abstract

The research team consisting of researchers at NIMS, RIKEN, Kobe Steel and JEOL RESONANCE (a consolidated subsidiary company of JEOL) successfully developed the NMR (nuclear magnetic resonance) system equipped with world’s highest magnetic field, 1,020 MHz, during engagement in the JST-SENTAN program “Development of Systems and Technology for Advanced Measurement and Analysis”. In addition, taking actual measurements with this new system, the team confirmed its considerably enhanced performance compared to conventional NMR systems in terms of sensitivity and resolution.

NMR systems have been used for various purposes including 3D conformational analysis of biopolymers such as proteins, organic chemistry and materials research. In particular, it is one of the indispensable tools for the development of new drugs. In the development of a new drug, it is vital to understand protein structures in a quick and accurate manner. In this view, improving the performance of NMR systems is of great importance. Magnetic field strength is a key indicator of the performance of NMR systems, and thus there had been fierce competition to develop NMR systems with magnetic fields greater than 1,000 MHz. For a long time, it was broadly expected that the use of high-temperature superconducting technology would enable producing magnetic fields above 1,000 MHz. However, because high-temperature superconductors had problems such as being fragile and difficult to process, no party had achieved their practical use for a long run.

Through developing several new technologies including the conversion of the high-temperature superconductor developed by NIMS in 1988 into the form of wire material, the research team recently created the NMR system equipped with world’s highest magnetic field at 1,020 MHz. Before making this accomplishment, the team spent 20 years of planning, designing and construction, as well as overcoming many hardships such as suspension of the project due to the damage to the nearly completed system caused by the Great East Japan Earthquake, encountering a serious worldwide shortage of helium supply, and the sudden passing of the team leader.

It is expected that the super-high magnetic field NMR will greatly contribute to various fields such as structural biology, analytical chemistry and materials engineering. Furthermore, considering that NMR requires a magnetic field with extraordinary precision, the high-temperature superconducting technology that was cultivated during the development of NMR is applicable to various high-tech systems such as MRI (magnetic resonance imaging), nuclear fusion, linear motor trains and superconducting power cables.

A part of this study was published in the Journal of Magnetic Resonance on May 15, 2015, and was presented at the Experimental Nuclear Magnetic Resonance Conference, the largest international conference on NMR, held from April 19 to 24 in the United States, and at the 57th Solid-State NMR and Materials Forum held on May 21, 2015 in Japan.

*World’s Highest Magnetic Field: 1020MHz (24.0T) As of Apr 17, 2015


Picture: Photo: A part of the recently developed 1,020 MHz-NMR system equipped with superconducting magnets (about 5 m high and weighing about 15 tons). This part contains coils made of a high-temperature superconductor. Liquid helium is used for cooling.

Photo: A part of the recently developed 1,020 MHz-NMR system equipped with superconducting magnets (about 5 m high and weighing about 15 tons). This part contains coils made of a high-temperature superconductor. Liquid helium is used for cooling.




Contacts

(Regarding this research)
Tadashi Shimizu
Director of the High Magnetic Field Station, National Institute for Materials Science
Tel: +81-29-863-5509
E-Mail: shimizu.tadashi=nims.go.jp
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Hideaki Maeda
Facility Director, Division of Structural and Synthetic Biology, Center for Life Science Technologies, RIKEN
Tel: +81-45-503-9267 (extension: 8029 or 3612)
E-Mail: maeda=jota.gsc.riken.go.jp
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Director of the Superconductivity Research Section, Electronics Research Laboratory, Kobe Steel, Ltd.
Tel: +81-78-992-5652
E-Mail: saito.kazuyoshi=kobelco.com
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Ryoji Tanaka
Expert, Engineering Division, Development Group, JEOL RESONANCE Inc.
Tel: +81-42-542-2236
E-Mail: rtanaka=jeol.co.jp
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(For general inquiries)
Public Relations Office
National Institute for Materials Sciences
1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, JAPAN
Tel: +81-29-859-2026
Fax: +81-29-859-2017
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Global Communications Team, RIKEN
Email: gro-pr@riken.jp
Tel: +81-48-462-1225
E-Mail: gro-pr=riken.jp
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Ken Yoshikawa
Secretariat & Publicity Department, Kobe Steel, Ltd.
Tel: +81-3-5739-6010
E-Mail: yoshikawa.ken=kobelco.com
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Izumi Oi
Director & Officer, Management Strategy Planning Division, JEOL Ltd.
Tel: +81-42-542-2144
E-Mail: oi=jeol.co.jp
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Public Relations Division
Japan Science and Technology Agency
Tel: +81-3-5214-8404
E-Mail: jstkoho=jst.go.jp
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(Regarding the JST’s program “Development of Systems and Technology for Advanced Measurement and Analysis”)
Office of Advanced Measuring Technology, Department of Industry-Academic Alliance
Japan Science and Technology Agency (JST)
Tel: +81-3-3512-3529
E-Mail: sentan=jst.go.jp
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National Institute for Materials Science (NIMS)
1-2-1 Sengen, Tsukuba-city
Ibaraki 305-0047 JAPAN