A New Promise for Cardiac Repair
- Tissue Engineering Using Stem Cells and Biocompatible Scaffolds -
A novel approach for cardiac tissue engineering has been successfully developed. Complete maturation of adult murine cardiac resident progenitor cells (CPC) towards cardiac phenotype was induced within few days by the cooperation of biological and mechanical stimuli, giving promise for patient novel treatments.
Left: Exploded view of the 3D biodegradable scaffold made of PLA (left).
Center: SEM micrograph of a CPC stretched bridging over the pore window.
Right: Immuno-fluorescence microscope image showing cell nuclei (blue) and cytoskeletal sarcomeres (red) of fully differentiated CPCs over the 3D scaffold.
Further information
Affiliations
Emiliana Fabbri1, Lei Bi1, Hidehiko Tanaka1, Daniele Pergolesi1, Enrico Traversa1
- International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS)
