1. Home
  2. > News Room
  3. > Hydroxyapatite/collagen nanocomposite-coated … …

Press ReleasePress Release 2013

Hydroxyapatite/collagen nanocomposite-coated titanium rod for achieving rapid osseointegration onto bone surface

8 Apr, 2013

Dr. Masanori KIKUCHI (Group Leader) in Bioceramics Group, Biomaterials Unit in MANA, and DDS. Masayoshi UEZONO and Prof. Kazuo TAKAKUDA and Prof. Keiji MORIYAMA in Tokyo Medical and Dental University have developed a new coating to bond bone and titanium three times faster than conventional calcium phosphate coatings.

Subperiosteal devices for orthodontic treatments are superior to screw type devices in viewpoint of lower invasion to our body. The problem is that they require a waiting time of at least 3 months before the treatment can be started even with conventional hydroxyapatite coatings, because the subperiosteal devices should be bonded onto bone surface and not into bone. To reduce this waiting time, the research group has established a new coating method using hydroxyapatite/collagen bone-like nanocomposite (HAp/Col, already approved as a bone filler) that achieves a favorable bone coverage ratio in only one month, in contrast to at least three months that are required in the case of conventional devices.

The method is expected to be conveniently applied to artificial tooth roots and artificial joints as well as the subperiosteal devices for orthodontic treatment.


Fig. 1: Histological section at 4 weeks after operation. Soft tissue (pink part) was found between titanium (black part) and bone tissue (Brown part) in upper two photos; whereas no soft tissue was observed between them in the bottom (HAp/Col: new coating) photo. In addition, bone coverage was obviously better in HAp/Col coating.

Further information


Masayoshi Uezono, Kazuo Takakuda, Masanori Kikuchi, Shoichi Suzuki, Keiji Moriyama, " Hydroxyapatite/collagen nanocomposite-coated titanium rod for achieving rapid osseointegration onto bone surface", Journal of Biomedical Materials Research Part B: Applied Biomaterials, (2013), DOI: 10.1002/jbm.b.32913.

World Premier International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS)

Contact information

For more detail about research

For Material and coating method:
Bioceramics Group, Biomaterials Unit, MANA, NIMS Group Leader Masanori Kikuchi TEL:+81-29-857-6301 E-mail: KIKUCHI.Masanori@nims.go.jp

For Device:
Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Professor Kazuo Takakuda TEL: 03-5280-8040 E-mail: takakuda.mech@tmd.ac.jp

For Orthodontic treatments:
Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Professor Keiji Moriyama, TEL: 03-5803-5532 E-mail: k-moriyama.mort@tmd.ac.jp

For general inquiry

Public Relations Office, NIMS
Email: prnims.go.jp
TEL:+81-29-859-2026 FAX:+81-29-859-2017

News Room