15:30-16:45

A New Polymeric “Nanogel” Carrier System for Delivery of Small Hydrophobic Drugs

In this talk I will describe a new carrier system for delivery of hydrophobic drugs. It is based on polymeric inclusion complexes formed by interaction of polymeric-drug conjugates (Poly-Drug) with polymeric cyclodextrins (Poly-CD). We have formed polymer-drug conjugates of Paclitaxel (PTX) with maleic anhydride copolymers. The PTX is linked to the backbone by a degradable ester bond. We also synthesized a maleic anhydride copolymer conjugated with beta-cyclodextrins (Poly-CD) where the CDs are also linked by degradable ester bonds to the backbone polymer. We then interacted the polymer-PTX with the polymer-CD to form an inclusion complex “nanogel”. PTX drug was efficiently released from this nanogel over many hours in in vitro tests. In this seminar I will describe the synthesis and performance of this new drug delivery system.

Speaker

Prof. Allan Hoffman, Department of Bioengineering, University of Washington, USA

Chair

Dr. Takao Aoyagi, MANA PI, MANA, NIMS