Takao Aoyagi

Takao Aoyagi
Biomaterials, Drug Delivery Systems (DDS)
Academic degree:
Ph.D. Tokyo Institute of Technology (1993)
Recent publications
See NIMS Researchers DB

Educational & Working History

2010 - Present Group Leader, Smart Biomaterials Group, MANA, NIMS
2009 - 2010 Coordinating Director, Managing Director, Biomaterials Center, NIMS
2002 Professor, Graduate School of Science and Engineering, Faculty of Engineering, Kagoshima University
1995 Assistant Professor, Institute of Biomedical Engineering,
Associate Professor, Institute of Advanced Biomedical Engineering,
Tokyo Women's Medical University
1993 Doctor of Engineering, Tokyo Institute of Technology
1986 Ph. D. in Physics, Tokyo Institute of Technology

Research Career

The research interest of Takao Aoyagi is to develop the novel biomedical materials aiming at tissue engineering, cell function control, targeted drug delivery and so on. To achieve the purpose, he has intended to design monomer and polymer structure as well as the network, interface and self-assembly using the developed polymers. In Sagami Chemical Research Center, he investigated very unique polymeric transdermal penetration enhancers. The polymeric compounds did not penetrate through the skin by themselves and only promoted the drug penetration. There, he also developed temperature-responsive polymeric materials comprising poly (e-caprolactone)-based polyesters. The materials nicely controlled the drug permeation near body temperature.

 After he moved to Tokyo Women's medical University, he challenged the novel biomaterials design. One of the achievements is the design and synthesis of temperature-responsive polymeric micelles. Another is the development of N-isopropylacrylamide-based functional monomers and polymers. The resulting copolymers contain comonomer random sequences based on very similar copolymerization reactivity, as well as show both the good chemical reactivity and nice stimuli-response. This work attracts much attention because the polymeric materials can be applied to many kinds of biomedical use. Until then, such types of polymeric materials have not been available.

In Kagoshima University, he carried out both fundamental study of temperature-responsive property of N-isopropylacrylamide-based polymers and their biomedical application such as nanoparticle and surface modification. One of the topics is the coacervate formation of the polymers. Through the study, he made the temperature-responsive mechanism including phase transition and phase separation clear.

Another one is combination of the polymers with magnetite particles. He succeeded to immobilization of the polymer onto the magnetite nanoparticle surface. The combination of inductive heating by alternating magnetic field (AMF) and such stimuli-responsive polymers gives some unique biomedical application. The surface-modified magnetic nanoparticles showed the sensitive response to AMF. The similar concept was applied to development of AMF-responsive chromatography. Taking the scale-up of biomolecule separation into consideration, this separation system would have some advantages because of no use of water-miscible organic solvent that is required for a conventional reverse-phase chromatography.

In NIMS, he continues to study the design of novel biomaterial and biomedical evaluation. Recent topics are temperature-responsive nano-fiber, double responsive block copolymer, elastic biodegradable polymeric material and they are promising materials for new nano-bio fields.

Selected Papers

  1. Stimuli-Responsive Coacervate Induced in Binary Functionalized Poly (N-isopropylacrylamide) Aqueous System and Novel Method for Preparing Semi-IPN Microgel Using the Coacervate
    T. Maeda, Y. Akasaki, K. Yamamoto, and T. Aoyagi
    Langmuir, 25, 9510-9517 (2009)
  2. Assembly behavior of double thermo-responsive block copolymers with controlled response temperature in aqueous solution
    Y. Kotsuchibashi, K. Yamamoto, and T. Aoyagi
    Journal of Colloid and Interface Science, 336, 67-72 (2009)
  3. New Liquid Chromatography Method Combining Thermo-responsive Material and Inductive Heating via Alternating Magnetic Field
    H. Yagi, K. Yamamoto, and T. Aoyagi
    Journal of Chromatography B, 876, 97-102 (2008)
  4. Synthesis and Characterization of Double Thermo-Responsive Block Copolymer Consisting N-isopropylacrylamide by Atom Transfer Radical Polymerization
    Y. Kotsuchibashi, Y. Kuboshima, K. Yamamoto, and T. Aoyagi
    Journal of Polymer Science, Part A: Polymer Chemistry, 46, 6142-6150 (2008)
  5. Preparation of Cross-linked Poly (ε-caprolactone-co-lactide) and Biocompatibility Studies for Tissue Engineering Materials
    H. Miyasako, K. Yamamoto, A. Nakao, and T. Aoyagi
    Macromolecular Bioscience, 7, 76-83 (2007)
  6. Temperature-responsive cross-linked poly(e-caprolactone) membrane that functions near body temperature
    K. Uto, K. Yamamoto, S. Hirase, and T. Aoyagi
    Journal of Controlled Release, 110, 408-413(2006)
  7. Hydroxylated Poly (N-isopropylacrylamide) as Functional Thermo-responsive Materials
    T. Maeda, T. Kanda, Y. Yonekura, K. Yamamoto, and T. Aoyagi
    Biomacromolecules, 7, 545-549(2006)
  8. Preparation and Characterization of Temperature-Responsive Magnetite Nanoparticle Conjugated with N-Isopropylacrylamide-based Functional Copolymer
    H. Wakamatsu, K. Yamamoto, A. Nakao, and T. Aoyagi
    Journal of Magnetism and Magnetic Materials, 302, 327-333(2006)
  9. Stimuli-Responsive Properties of N-Isopropylacrylamide-Based Ultrathin Hydrogel Films Prepared by Photo-Cross-Linking
    D. Matsukuma, K. Yamamoto, and T. Aoyagi
    Langmuir, 22, 5911-5915 (2006)
  10. Newly Designed Hydrogel with both Sensitive Thermo-response and Biodegradability
    T. Yoshida, T. Aoyagi, E. Kokufuta, and T. Okano
    Journal of Polymer Science, Polymer Chemistry, 41(6) 779-787 (2003)
  11. Incorporation of carboxylate groups into temperature-responsive poly (N-isopropylacrylamide)-based hydrogels promotes rapid gel shrinking
    M. Ebara, T. Aoyagi, K. Sakai and T. Okano
    Journal of Polymer Science, Polymer Chemistry, 39, 335-342 (2001)
  12. Introducing reactive carboxyl side chains retains phase transition temperature-sensitivity in N-isopropylacrylamide copolymer gels
    M. Ebara, T. Aoyagi, K. Sakai and T. Okano
    Macromolecules, 33, 8312-8316 (2000)
  13. Novel bifunctional polymer with reactivity and temperature sensitivity
    T. Aoyagi, M. Ebara, K. Sakai, Y. Sakurai and T. Okano
    Journal of Biomaterials Sciences, Polymer Edition, 11, 101-110 (2000)