10:00-10:45

Tubular Scaffold using Gelatin and Poly(ε-caprolactone)-Poly(γ-glutamic acid) Block Copolymer

Smooth muscle cells (SMCs) are thought to play an important role to regenerate various tissues. The present study aims to fabricate a composite tubular scaffold of gelatin and poly(ε-caprolactone)-poly(γ-glutamic acid) block copolymer (G-CG) for the regeneration of small intestine. G-CG scaffolds were cross-linked using carbodiimide method. The SEM micrographs showed the outer and inner surface of G-CG scaffolds were smooth, yet the cross section was porous with pore size of 100-300 μm. The storage moduli of G-CG scaffolds were 70-140 Pa. It was found that the gelatin can decrease in vitro degradation from 72.3 % to 49.4 %. To optimize cell seeding in the scaffolds, SMCs were seeded using static seeding (SS) and centrifugal cell immobilization (CS), respectively. After incubating for 28 days, the cell density of CS groups (1×10⁶ cells/cm³) was higher than that of SS groups (8×10⁵ cells/cm³). After SMCs were stained by Live/DeadR reagents, the confocal microscopic images of SMCs in G-CG scaffolds displayed well-spreading morphology indicating a biocompatible nature of G-CG scaffolds.

Speaker

Prof. Ming-Fa Hsieh, Department of Biomedical Engineering, Chung Yuan Christian University, Taiwan

Chair

Dr. Guoping Chen, MANA PI, Tissue Regeneration Materials Unit, NIMS

10:45-11:30

"Pyroelectric and Photovoltaic Surface Potential in Ferroelectrics"

-New Applications for Molecule Manipulation, Solar Cell, Crystal Accelerator-

LiNbO₃ (LN)and LiTaO₃ (LT) crystals are typical ferroelectric materials possessing excellent piezo-electric, pyro-electric, opto-electric, photovoltaic and non-linear optical properties. There is no material except them which has been studied and applied in so wide fields. Recently, surface potential induced by their pyrolelctric, photovoltaic and domain wall effects has been deserving our attention. They have a potential of emitting electrons; electron energies up to 10⁵ eV and electric fields as high as 10⁶ Vcm^-1, it is currently applied to infrared sensors, X-ray generators, neutron generators, and tabletop nuclear fusion systems using their large pyroelectricity. Besides, they have a strong effect on reactivity on their polar surfaces. By combining domain patterning with domain-specific reaction, we demonstrated metallic nanostructures and nanopartilces and their new applications. Moreover, ferroelectric-solar cell hybrid devices are becoming attractive. In this talk, such new prospects using surface potential on polar materials will be reviewed by showing our recent results related with them.

Speaker

Dr. Kenji Kitamura, Fellow, Group Leader (Former MANA PI), Optical & Electronic Materials Unit, Polar Domain Engineering Group

Chair

Dr. Yoshio Bando, MANA COO, NIMS