2021年
(原著論文)

Sosuke Ouchi,a,b Eri Niiyama,a,c Ken Sugo,a,c Koichiro Uto,a Satoshi Takenaka,d Akihiko Kikuchi b and Mitsuhiro Ebara, "Shape-Memory Balloon Offering Simultaneous Thermo/Chemotherapies to Improve Anti-Osteosarcoma Efficacy ", Biomaterials Science, in press.

Ahmed Nabil, Erika Yoshihara, Keita Hironaka, Ayman A Hassan , Gamal Shiha, Mitsuhiro Ebara, "Temperature responsive smart polymer for enabling affinity enrichment of current coronavirus (SARS-CoV-2) to improve its diagnostic sensitivity", Computational and Structural Biotechnology Journal, 19:3609-3617(2021). DOI: 10.1016/j.csbj.2021.06.016.

Nanami Fujisawa, Masato Takanohashi, Lili Chen, Koichiro Uto, Yoshitaka Matsumoto, Masayuki Takeuchi, and Mitsuhiro Ebara, "A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy",Science and Technology of Advanced Materials , 22, 1, 522–531(2021). https://doi.org/10.1002/mp.14516.

Makoto Sasaki, Yihua Liu and Mitsuhiro Ebara, "Zeolite composite nanofiber mesh for indoxyl sulfate adsorp-tion toward wearable blood purification devices", Fibers, 9(6), 37(2021). https://doi.org/10.3390/fib9060037.表紙に掲載

Keita Hironaka, Erika Yoshihara, Ahmed Nabila, James J. Lai, Akihiko Kikuchi, Mitsuhiro Ebara, "Conjugation of antibody with temperature-responsive polymer via in situ click reaction to enable biomarker enrichment for increased diagnostic sensitivity", Biomaterials Science, 9, 4870-4879 (2021). https://doi.org/10.1039/D1BM00349F.表紙に掲載

Laszlo Szabo, XingtaoXu, TakeoOhsawa, KoichiroUto, Joel Henzie, Izumi Ichinose,Mitsuhiro Ebara, "Ultrafine self-N-doped porous carbon nanofibers with hierarchical pore structure utilizing a biobased chitosan precursor", International Journal of Biological Macromolecules, 182, 445–454 (2021). https://doi.org/10.1016/j.ijbiomac.2021.04.023.

Ahmed Nabil,?Koichiro Uto,?Faten Zahran,?Reham Soliman,?Ayman A. Hassan,?Mohamed M. Elshemy,?Islam S. Ali,?Mitsuhiro Ebara,?G. Shiha, " The Potential Safe Anti-Fibrotic Effect of Stem Cells Conditioned Medium & Nilotinib Combined Therapy by Selective Elimination of Rat Activated HSCs", BioMed Research International, 2021, 6678913, 9 pages (2021). https://doi.org/10.1155/2021/6678913.

Kazuro Lee Fujimoto, Aika Yamawaki-Ogata, Yuji Narita, Akihiko Usui, Koichiro Uto, Mitsuhiro Ebara, "Long term efficacy and fate of a right ventricular outflow tract replacement using a novel developed material with optimized biodegradation and elasticity", Acta Biomaterialia, 123, 222-229 (2021). https://doi.org/10.1016/j.actbio.2021.01.022.

Mohamed M. Elshem, Medhat Asem, Khaled S. Allemailem, Koichiro Uto, Mitsuhiro Ebara and Ahmed Nabil, "Anti-Oxidative Capacity of Liver and Adipose-Derived Mesenchymal Stem Cells Conditioned Media and their Applicability in Treatment of Type 2 Diabetic Rats", Oxidative Medicine and Cellular Longevity, Article ID 8833467 (2021). https://doi.org/10.1155/2021/8833467.

Lili Chen, Nanami Fujisawa, Masato Takanohashi, Mazaya Najmina, Koichiro Uto and Mitsuhiro Ebara, A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy", International Journal of Molecular Science, 22, 2542 (2021). https://doi.org/10.3390/ijms22052542.

 

(総説・著書など)

荏原充宏, “第1章 刺激応答性高分子の基礎知識”, 刺激応答性高分子の開発動向(監修:荏原), 株式会社シーエムシー出版, 1-8 (2020). ISBNコード:978-4-7813-1611-6.

中川泰宏,荏原充宏, “第10章 糖応答型スマートポリマーを用いた人工レクチンの開発”, 刺激応答性高分子の開発動向(監修:荏原), 株式会社シーエムシー出版, 149-157 (2020). ISBNコード:978-4-7813-1611-6.

藤澤七海,荏原充宏, 第10章 スマートポリマーを用いた貼るがん治療”, 刺激応答性高分子の開発動向(監修:荏原), 株式会社シーエムシー出版, 158-164 (2020). ISBNコード:978-4-7813-1611-6.

荏原充宏, “ 特集 医療の未来を変えるか。スマートポリマー”, 医師協Times, 大阪府医師共同組合, 4, 296, 2-4 (2021).

吉原栄理佳、荏原充宏, “ スマートポリマーによるグローバルヘルスへの挑戦〜感染症の早期診断への応用を目指して〜”,金属, 91, 5, 54-59 (2021).

Ahmed Nabil, Mohamed M. Elshemy, Reham Soliman, Ayman A. Hassan, Koichiro Uto, Gamal Shiha, Mitsuhiro Ebara, “ Coronavirus (SARS-CoV-2) in gastroenterology and its current epidemiological situation: An updated review until January 2021”,EXCLI Journal , 20, 366-385 (2021). doi: 10.17179/excli2021-34176.

藤澤七海、荏原充宏, “体内移植型局所薬物送達プラットフォームとしての
スマートナノファイバーメッシュ“,Material Matters・材料科学の基礎, MERCK, Vol.15 No.3, 113 (2020).

2020年
(原著論文)

Takahiro Aoyama, Koichiro Uto, Hidetoshi Shimizu, Mitsuhiro Ebara, Tomoki Kitagawa, Hiroyuki Tachibana, Kojiro Suzuki, Takeshi Kodaira, "Physical and dosimetric characterization of thermoset shape memory bolus developed for radiotherapy", The International Journal of Medical Physics Research and Practice, 47(12), 6103-6112 (2020). https://doi.org/10.1002/mp.14516.

Junichi Sayanagi, Hiroyuki Tanaka, Mitsuhiro Ebara, Kiyoshi Okada, Kunihiro Oka, Tsuyoshi Murase, and Hideki Yoshikawa, "Combination Therapy of an Electrospun Nanofiber Sheet Incorporating Methylcobalamin and a PGA collagen Tube for the Treatment of a Rat Sciatic Nerve Defect Model", The Journal of Bone and Joint Surgery, 102(3):245-253 (2020). doi: 10.2106/JBJS.19.00254.

Mazaya Najimina, Koichiro Uto, Mitsuhiro Ebara, "Fluidic Substrate As A Tool To Probe Breast Cancer Cell Adaptive Behavior In Response To Fluidity Level", Polymer Journal,52, 985-995 (2020). https://doi.org/10.1038/s41428-020-0345-6.

Motoki Okamoto, Sayako Matsumoto, Ayato Sugiyama, Kei Kanie, Masakatsu Watanabe, Hailing Huang, Manahil Ali, Yuki Ito, Jiro Miura, Yujiro Hirose, Koichiro Uto, Mitsuhiro Ebara, Ryuji Kato, Aika Yamawaki-Ogata, Yuji Narita, Shigetada Kawabata, Yusuke Takahashi and Mikako Hayashi , "Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair", polymers, 12, 937 (2020). doi:10.3390/polym12040937.

Ahmed Nabil, Mohamed M. Elshemy, Medhat Asem, Marwa Abdel-Motaal, Heba F. Gomaa, Faten Zahran, Koichiro Uto, and Mitsuhiro Ebara, "Zinc Oxide Nanoparticle Synergizes Sorafenib Anticancer Efficacy with Minimizing Its Cytotoxicity", Oxidative Medicine and Cellular Longevity, 2020, 1362104 (2020). https://doi.org/10.1155/2020/1362104.

Sharmy Saimon Mano, Koichiro Uto, Mitsuhiro Ebara, "Fluidity of Poly (ε-caprolactone)-Based Material Induces Epithelial-to- Mesenchymal Transition", ernatioal Journal of Molecular Sciences, 21(5) 1757 (2020). 10.3390/ijms21051757.

Ken Sugo, Mitsuhiro Ebara, "A Simple Spectrophotometric Evaluation Method of Hydrophobic Anticancer Drug Paclitaxel", PeerJ Analytical Chemistry, 2:e3 (2020). https://doi.org/10.7717/peerj-achem.3.

 

(総説・著書など)

Mingwei Mu, Mitsuhiro Ebara, “Chapter 12: Smart Polymers Polymer Science and Nanotechnology -Fundamentals and Applications”, Elsevier, 257-279(2020).

Ahmed Nabil, Koichiro Uto, Mohamed M. Elshemy, Reham Soliman, Ayman A. Hassan, Mitsuhiro Ebara, Gamal Shiha, “ Current Coronavirus (SARS-CoV-2) Epidemiological, Diagnostic and Therapeutic Approaches: An Updated Review until May 2020”, EXCLI Journal, 19, 992–1016(2020).

Mitsuhiro Ebara, “Smart Nanofiber Meshes as a Local Drug Delivery Platform“, Material Matters, MERCK, vol 15, No.3, 113-116 (2020).

宇都甲一郎, 荏原充宏, “細胞老化とがん治療 -マテリアル誘導性細胞老化(MIS)の可能性-”, 特集:老化現象とバイオマテリアル, バイオマテリアルー生体材料ー, 38巻3号166-171(2020.

新山瑛理,田邉貫太,宇都甲一郎,菊池明彦,荏原充宏, “形状記憶ナノファイバーの設計 〜細胞の配向性制御を目指して〜”, バイオマテリアルー生体材料ー, 38-1, 64-65 (2020).

菅生健,大内創介,荏原 充宏, ““貼る癌治療”を目指したスマートポリマー開発”, 生体適合性材料や医用高分子の開発,その応用事例, MATERIAL STAGE, 19 (10), 29-33 (2020).

荏原充宏, “巻頭言”, 特集スマートポリマーの最新展望, 月刊機能材料, シーエムシー出版, 40 (5), 3 (2020).

中川泰宏,荏原充宏, “糖応答型スマートポリマーを用いた人工レクチンの開発”, 特集スマートポリマーの最新展望, 月刊機能材料, シーエムシー出版, 40 (5), 33-40 (2020).

中川泰宏,荏原充宏, “非蛋白性合成レクチンを用いた糖認識バイオマテリアル”, 糖鎖を標的とした工学的アプローチ,レクチン医学最前線, 別冊・医学のあゆみ,医歯薬出版, 75-81 (2020).

2019年
(原著論文)

Satoshi Miyamura, Toru Iwahashi, Junichi Sayanagi, Yukio Hirai, Kiyoshi Okada, Kunihiro Oka, Eri Niiyama, Koichiro Uto, Mitsuhiro Ebara, Hideki Yoshikawa, Tsuyoshi Murase, Hiroyuki Tanaka, "A Nanofiber Sheet Incorporating Vitamin B12 Promotes Nerve Regeneration in a Rat Neurorrhaphy Model", Plastic and Reconstructive Surgery, 7, 12, e2538 (2019). doi: 10.1097/GOX.0000000000002538.

Melanie A. Fuller, Ashley Carey, Harriet Whiley, Mitsuhiro Ebara, Ingo Koper, "Nanoparticles in an Antibiotic-Loaded Nanomesh for Drug Delivery ", RSC Advances, 9, 30064-30070 (2019). DOI: 10.1039/c9ra06398f.

Eri Niiyama, Koichiro Uto, Mitsuhiro Ebara, "Electrospun PCL-PCL Polyblend Nanofibers with High- and Low-molecular Weightfor Controlled Degradation", Chemistry Letters, 48(7), 623-626 (2019). https://doi.org/10.1246/cl.190100.

E. Niiyama, K. Uto, C. M. Lee, K. Sakura, M. Ebara, "Hyperthermia Nanofiber Platform Synergized by Sustained Release of Paclitaxel to Improve Anti-tumor Efficiency", Advanced Healthcare Materials, 8(13) 1900102 (2019). https://doi.org/10.1002/adhm.201900102. 表紙に掲載

E. Niiyama, K. Tanabe, K. Uto, A. Kikuchi, M. Ebara, "Shape-memory NanoShape-Memory Nanofiber Meshes with Programmable Cell Orientation fiber Meshes with Programmable Cell Orientation", Fibers, 7(3), 20 (2019). https://www.mdpi.com/2079-6439/7/3/20.表紙に掲載

M. Tsuge, K. Takahashi, R. Kurimoto, A. Fulati, K. Uto, A. Kikuchi, M. Ebara, "Fabrication of Water Absorbing Nanofiber Meshes toward an Efficient Removal of Excess Water from Kidney Failure Patients", Fibers, 7(5), 39 (2019). https://doi.org/10.3390/fib7050039.表紙に掲載

Y. Nakagawa, Y. Yano, J. Lee, Y. Anraku, M. Nakakido, K. Tsumoto, H. Cabral , M. Ebara, "Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Diseases Treatment", ACS Biomaterials Science & Engineering, 5(11), 5705-5713 (2019). https://doi.org/10.1021/acsbiomaterials.8b01510.表紙に掲載

S. Yoneoka, Y. Nakagawa, K. Sakura, M. Ebara, T. Tsukahara, "Boron-Incorporating Hemagglutinating Virus of Japan Envelope (HVJ-E) Nanomaterial in Boron Neutron Capture Therapy", Science and Technology of Advanced Materials, 20(1), 291-304 (2019). https://doi.org/10.1080/14686996.2019.1586051.

S. Yoneoka, K. C. Park, Y. Nakagawa, M. Ebara, T. Tsukahara, "Synthesis and Evaluation of Thermoresponsive Boron-Containing Poly(N-isopropylacrylamide) Diblock Copolymers for Self-Assembling Nanomicellar Boron Carriers", Polymers, 11(1), 42 (2019). https://doi.org/10.3390/polym11010042.

 

(総説・著書など)

中川泰宏, 荏原充宏, “抗炎症性を有する新たなバイオマテリアル開発”, 人工臓器開発に貢献するバイオマテリアル,人工臓器, 48 (3), 210-213 (2019).

新山瑛理, 荏原充宏, “第1節 抗癌活性を有するナノファイバーメッシュの作製”, ナノファイバーの製造・加工技術とその応用事例,技術情報協会, 407-410 (2019).

荏原充宏, “8. メカノバイオロジー:スマートポリマーによる細胞操作” ,医療を支える新素材,現代科学, 東京化学同人,11月号No.584, 51-53.

新山瑛理, 荏原充宏, “温熱・化学療法を同時に実現するスマートナノファイバーの開発〜貼るがん治療を目指して〜”, 特集“DDSを支える高分子材料の精密設計・成形・構造制御技術”,Drug Delivery System, 日本DDS学会,31-3, 179-185 (2019).

栗本理央, 蟹江慧, 荏原充宏, 加藤竜司, “第V編 高分子 第6章高分子材料への細胞選択的ペプチド修飾による生体適合性付与”, 監修者:`島由二,無機/有機材料の表面処理・改質による生体適合性付与, 株式会社シーエムシー出版,189-197 (2019).ISBN:978-4-7813-1415-0

中川泰宏,荏原充宏, “非タンパク性合成レクチンを用いた糖認識バイオマテリアル”, 糖鎖を標的とした工学的アプローチ,レクチン医学最前線, 医学のあゆみ,vol.269, No.9, 703-709 (2019).

荏原充宏, “局所がん治療を目指したナノファイバーの開発”, 特集ナノテクノロジー 未来社会を創生するナノテクノロジー,WEB Journal,8月号19-22(2019).

M. Ebara, “Apoptotic Cell-Mimetic Polymers for Anti-Inflammatory Therapy”, Chonnam Medical Journal,55(1), 1-7 (2019).

荏原充宏, “科学ヒーローたちの弁当代は誰が払うべきか?”, 巻頭エッセイ カガクへの視点,化学,74, 11 (2019).

2018年

(原著論文)

E. Niiyama, K. Uto, C. M. Lee, K. Sakura, M. Ebara, "Alternating Magnetic Field-Triggered Switchable Nanofiber Mesh for Cancer Thermo-Chemotherapy", Polymers, 10(9),1018 (2018). https://doi.org/10.3390/polym10091018.

K. Uto, T. Aoyagi, C. A. DeForest, M. Ebara, "Dynamic Alterations of Hepatocellular Function by On-demand Elasticity and Roughness Modulation",Biomaterials Science, 6(5),1002-1006 (2018). DOI:10.1039/C8BM00047F.

R. Kurimoto, K. Namekawa, A. V. Ellis, M. Naito, M. Ebara, "Selective Adsorption of Globulin on Nanofiber Meshes for Immunoadsorption Therapy", New Journal of Chemistry, 42(4), 2916-2922 (2018). DOI:10.1039/C7NJ04672C.

Y. Nakagawa,Hiroaki Tateno, M. Ebara, "Investigation of Selective Recognition of Sugars Using Lectin-inspired Temperature-responsive Polymers", Chemistry Letters, 47(2), 134-137 (2018). DOI:10.1246/cl.170967.表紙に掲載

Y. Nakagawa, A. Saitou, T. Aoyagi, M. Ebara, "Rational Design of Anti-inflammatory Polymers Inspired by Apoptotic Cell Death using Phosphoramidite Chemistry",Polymer, 134(3), 85-93 (2018). https://doi.org/10.1016/j.polymer.2017.11.031

K.Uto, T. Aoyagi, D.-H. Kim, M. Ebara, "Free-standing Nanopatterned Poly(ε-caprolactone) Thin Films as a Multifunctional Scaffold", IEEE Trans. Nanotech., 17(3), 389-392 (2018). DOI:10.1109/TNANO.2017.2770217

Q. Shou, M. Ebara, J. Wang, Q. Wang, X. Liang, H. Liu, T. Aoyagi, "Preparation of Phase Diagram of Gold Nanorods in Mixture Solvent of DMSO and Water and Its Application for Efficient Surface-modification", Applied Surface Science, 457(1),264-270 (2018). https://doi.org/10.1016/j.apsusc.2018.06.261.

W. Lin, I. Yeh, E. Niyama, W. Huang, M. Ebara, C. Wu, M. Ebara, "Electrospun Poly(ε-caprolactone) Nanofibrous Mesh for Imiquimod Delivery in Melanoma Therapy", Polymers, 10(3), 231 (2018). https://doi.org/10.3390/polym10030231.

(総説・著書など)

荏原充宏, “スマートポリマーxIoT”, トピックス,高分子,67(5), 247-248 (2018).

荏原充宏, 栗本理央, “自己免疫疾患治療のための免疫吸着ファイバーの開発”, 特集ANEX2018 アジア不織布産業の進展と展望,WEB Journal,5, 8-10 (2018).

荏原充宏, “人が想像できることは必ず実現できる〜携帯型透析装置への挑戦”, 第20回日本腎不全看護学会・学術集会記録,20巻1号21-25(2018).

荏原充宏, “バイオマテリアル”, 見たい!知りたい!大学探検隊,Sundai Advance, 2, 31-33 (2018).

荏原充宏, “応用編第1章第8節 温度応答性形状記憶ポリマーの設計と医療応用”, 刺激応答性高分子ハンドブック, 監修 宮田隆志,エヌ・ティー・エス,394-399 (2018).

E. Niiyama, A. Fulati, M. Ebara, “2 Chapter 2 Responsive Polymers for Smart Textiles", Smart Textiles: Wearable Nanotechnology”, Edited by N. D. Yilmaz,  Wiley-Scrivener,111-126 (2018).

 

Materials Nanoarchitectonics, Edited by M. Aono, K. Ariga, M. Ebara, Wiley, ISBN:9783527808311

2017年

(原著論文)

Y. Nakagawa, A. Saitou, T. Aoyagi, M. Naito, M. Ebara, "Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression", ACS Macro Letter, 6 (9), 1020-1024 (2017). DOI:10.1021/acsmacrolett.7b00592

S. S. Mano, K. Uto, M. Ebara, "Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5 ", Theranostics, 7 (19), 4658-4670 (2017). DOI:10.7150/thno.20582

K. Uto, M. Ebara , "Magnetic-Responsive Shape Memory Microparticles Exhibit Shape Switching at 37 oC", Applied Science, 7 (11), 1203 (2017). DOI:10.3390/app7111203

D. Diaz-Dussan, Y. Nakagawa, Y. Y. Peng, L. V. Sanchez C, M. Ebara, P. Kumar, R. Narain, "Effective and Specific Gene Silencing of Epidermal Growth Factor Receptors Mediated by Conjugated Oxaborole and Galactose-Based Polymers", ACS Macro Letter, 6 (7), 768-774 (2017). DOI:10.1021/acsmacrolett.7b00388

Y. Kotsuchibashi, T. Takiguchi, M. Ebara, T. Aoyagi, "The Effects of the Photo-Induced Proton Generation on the Assembly Formation of Dual-Temperature and pH Responsive Block Copolymers", Polymer Chemistry, 8, 295-302 (2017). DOI:10.1039/c6py01269h

Y. Kotsuchibashi, C.-M. Lee, I. Constantinescu, L. E. Takeuchi, S. Vappala, J. N. Kizhakkedathu, R. Narain, M. Ebara, T. Aoyagi, "A Nanoparticle-Preparation Kit Using Ethylene Glycol-Based Block Copolymers with a Common Temperature Responsive Block", Polymer Chemistry, 8, 7311-7315 (2017). DOI:10.1039/C7PY01541K

K. Uto, T. Aoyagi, C. A. DeForest, A. S. Hoffman, M. Ebara, "A Combinational Effect of "Bulk" and "Surface" Shape-Memory Transitions on the Regulation of Cell Alignment", Advanced Healthcare Materials, 6 (9), 1601439 (2017). DOI:10.1002/adhm.201601439

K. Suzuki, H. Tanaka, M. Ebara, K. Uto, H. Matsuoka, S. Nishimoto, K. Okada, T. Murase, H. Yoshikawa, "Electrospun Nanofiber Sheets Incorporating Methylcobalamin Promote Nerve Regeneration and Functional Recovery in A Rat Sciatic Nerve Crush Injury Model", Acta Biomaterialia, 53, 250-259 (2017). https://doi.org/10.1016/j.actbio.2017.02.004

T. Sato, T. Aoyagi, M. Ebara, R. Auzely-Velty, "Catechol-modified Hyaluronic Acid: In Situ-forming Hydrogels by Auto-oxidation of Catechol or Photooxidation using Visible Light", Polymer Bulletin, 74, 4069-4085 (2017). DOI:10.1007/s00289-017-1937-y

T. Maeda, Y.-J. Kim, T. Aoyagi, M. Ebara, "The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications", Fibers, 5, 13 (2017). DOI:10.3390/fib5010013

(総説・著書など)

荏原充宏, “手足の痺れや痛みを治療するナノファイバーメッシュ”, 特集1/医療・衛材・資材,WEB Journal,10, 12-15 (2017).

荏原充宏, “「スマートポリマー」〜怪我や病気の新しい治療法に役立つ材料としての可能性〜”, マテリアルニュース&トピックス,Material Stage,17, 4, (2017).

Mitsuhiro Ebara, Session 1 Fiber Sheet Drug Administration, Smart Polymer x Future Medicine, Convertech International, July/Aug. 88-91 (2017).

Mitsuhiro Ebara, Session 2 Developing an Early Diagnosis System That Can Also Be Utilized in Developing Countries, Smart Polymer x Future Medicine, Convertech International, Sept./Oct. 96-99 (2017).

Mitsuhiro Ebara, Session 3 Developing Medical Devices That can Also Be Used During Disasters, Smart Polymer x Future Medicine, Convertech International, Nov./Dec. 80-83 (2017).

荏原充宏, “第3回災害時でも利用可能な医療デバイスの開発”, スマートポリマーx未来医療,コンバーテック,Vol.532, No.7, 92-95 (2017).

荏原充宏, “第2回途上国でも利用可能な早期診断に向けて”, スマートポリマーx未来医療,コンバーテック,Vol.531, No.6, 72-75 (2017).

荏原充宏, “第1回貼って治療するファイバーシート”, スマートポリマーx未来医療,コンバーテック,Vol.530, No.5, 97-99 (2017).

宇都甲一郎,荏原充宏, “形状記憶性を有する生分解性ポリマー”, 特集:医療を支える高機能高分子材料の研究・開発最前線,工業材料,Vol.65, No.7, 61-67 (2017).

新山瑛理,宇都甲一郎,荏原充宏, “第1章ナノファイバーシートによるガン治療”, 第4編シート・繊維材料の開発と応用, 医療用バイオマテリアルの研究開発,シーエムシー出版,187-194 (2017).

新山瑛理,荏原充宏, “抗癌活性を有するナノファイバーメッシュの開発”, 化学工学会誌, 81(3), 137-139 (2017).表紙に掲載

 

2016年

(原著論文)

T. Sato, K. Uto, T. Aoyagi, M. Ebara, "An Intriguing Method for Fabricating Arbitrarily Shaped “Matreshka” Hydrogels Using a Self-Healing Template", Materials, 9(11), 864 (2016). DOI:10.3390/ma9110864

T. Sato, M. Ebara, "Fabrication of Temperature-responsive Hydrogels with Arbitrary Geometries by Using Self-healing Template", Chemistry Letters, 45(12), 1394-1396 (2016). (Editor's Choice) DOI:10.1246/cl.160796

R. Kurimoto, K. Kanie, K. Uto, S. Kawai, M. Hara, S. Nagano, Y. Narita, H. Honda, M. Naito, M. Ebara, R. Kato, "Combinational Effects of Polymer Viscoeasticity and Immobilized Peptides on Cell Adhesion to Cell-selective Scaffolds", Analytical Science, 32(11), 1195-1202 (2016). DOI: 10.2116/analsci.32.1195

R. Takai, R. Kurimoto, Y. Nakagawa, Y. Kotsuchibashi, K. Namekawa, M. Ebara, "Towards a Rational Design of Zeolite-Polymer Composite Nanofibers for Efficient Adsorption of Creatinine", Journal of Nanomaterials, 2016 (2016), Article ID 5638905, 7 pages. http://dx.doi.org/10.1155/2016/5638905

R. Kurimoto, K. Kanie, N. Idota, M. Hara, S. Nagano, T. Tsukahara, Y. Narita, H. Honda, M. Naito, M. Ebara, R. Kato, "Combinational Effect of Cell Adhesion Biomolecules and Their Immobilized Polymer Property to Enhance Cell-selective Adhesion", International Journal of Polymer Science, 2016 (2016), ID 2090985, 9 pages. http://dx.doi.org/10.1155/2016/2090985

S. Ishii, K. Uto, E. Niiyama, M. Ebara, T. Nagao, "Hybridizing Poly(ε-caprolactone) and Plasmonic Titanium Nitride Nanoparticles for Broadband Photoresponsive Shape Memory Films", ACS Applied Materials & Interfaces, 8, 5634-5640 (2016). doi:10.1021/acsami.5b12658

P. Y. Mengsteab, K. Uto, A. S. T. Smith, S. Frankel, E. Fisher, Z. Nawas, J. Macadangdang, M. Ebara, D.-H. Kim, "Spatiotemporal Control of Cardiac Anisotropy Using Dynamic Nanotopographic Cues", Biomaterials, 86, 1-10 (2016). doi:10.1016/j.biomaterials.2016.01.062

K. Uto, S. S. Mano, T. Aoyagi, M. Ebara, "Substrate Fluidity Regulates Cell Adhesion and Morphology on Poly(ε-caprolactone)-Based Materials", ACS Biomaterials Science & Engineering, in press. doi:10.1021/acsbiomaterials.6b00058

Y. Kotsuchibashi, M. Ebara, "Facile Functionalization of Electrospun Poly(ethylene-co-vinyl alcohol) Nanofibers via the Benzoxaborole-Diol Interaction", Polymers, 8(2), 41 (2016) . doi:10.3390/polym8020041

T. Okada, E. Niiyama, K. Uto, T. Aoyagi, M. Ebara, "Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy ", Materials, 9(1), 12 (2016). doi:10.3390/ma9010012

S. S. Mano, K. Uto, T. Aoyagi, M. Ebara," Fluidity of Biodegradable Substrate Regulates Carcinoma Cell Behavior: A Novel Approach to Cancer Therapy ", AIMS Materials Science, 3(1), 66-82 (2016). doi:10.3934/matersci.2016.1.66

T. Okada, K. Uto, T. Aoyagi, M. Ebara," Design of Hemagglutinable Viral-Mimetic Surfaces with A Monolayer of Inactivated Sendai Virus (HVJ-E) ", Biomaterials Science, 4, 96-103 (2016). 表紙に掲載 doi:10.1039/C5BM00375J

(総説・著書など)

荏原充宏, “医療に革命をもたらすスマートポリマーの開発”, 化学経済, 12月号10-13(2016).

荏原充宏, “ナノファイバーを用いた新たながん治療の提案”, 特集1/医療・衛材・資材, WEB Journal, 10, 7-10 (2016).

蟹江慧, 栗本理央, 荏原充宏, 加藤竜司, “細胞接着の性能を高める「ペプチドー合成高分子」ハイブリッド素材の開発”, トピックス, B&I, 74(6), 519-521 (2016).

松本卓也,荏原充宏,松崎典弥, “2.5 物理化学環境の整備”, 細胞社会学(大和雅之 編著), コロナ社, 62-77 (2016).

Y. Kotsuchibashi, M. Ebara, T. Aoyagi, "Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications", Polymers, 8(11), 380 (2016). doi:10.3390/polym8110380

S. Bou, A.V. Ellis, M. Ebara, "Synthetic Stimuli-responsive 'Smart' Fibers", Current Opinion in Biotechnology, 39, 113-119 (2016). doi:10.1016/j.copbio.2016.03.009

K. Ariga, K. Minami, M. Ebara, J. Nakanishi, "What Are Emerging Concepts and Challenges in NANO?: Nanoarchitectonics, Hand-Operating Nanotechnology, and Mechanobiology", Polymer Journal, 48, 371-389 (2016). doi:10.1038/pj.2016.8

中西淳, 荏原充宏, 吉川千晶, “バイオマテリアル研究のためのメカノバイオロジーの基礎と今後の展開”, 特集:メカノバイオロジーとバイオマテリアル, 生体材料, 34(2), 2-7 (2016).

荏原充宏, “細胞メカノバイオロジー応用のための形状記憶バイオマテリアルの設計”, 特集:平成27年度日本バイオマテリアル学会各賞紹介, 生体材料, 34(1), 18-19 (2016).

Biomaterials Nanoarchitectonics, Edited by M. Ebara, Elsevier, ISBN: 9780323371278

M. Ebara, K. Uto “Chapter 8 Gold Nanomaterials for Gene Therapy.” Polymers And Nanomaterials For Gene Therapy, Edited by R. Narain, Elsevier, 189-214 (2016). ISBN: 9780081005200

M. Ebara, K. Uto “Chapter 11 Stimuli-responsive Polymeric Substrates for Cell-matrix Mechanobiology.” Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology, Edited by D.-H. Kim, Cambridge University Press, 186-202 (2016). ISBN: 9781107078390

 

2015年

(原著論文)

C. Jiang, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki, "Implementation of Poly(ε-caprolactone) Sheet-based Shape-Memory Polymer Microvalves into Plastic-based Microfluidic Devices", Japanese Journal of Applied Physics, 54, 06FN02 (2015). doi:10.7567/JJAP.54.06FN02

R. Garrett, E. Niiyama, Y. Kotsuchibashi, K. Uto, M. Ebara, "Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma", Fibers, 3, 478-490 (2015). doi:10.3390/fib3040478

H.-L. Che, H. J. Lee, K. Uto, M. Ebara, W. J. Kim, T. Aoyagi, I.-K. Park. “Simultaneous Drug and Gene Delivery from The Biodegradable Poly(ε-caprolactone) Nanofibers for The Treatment of Liver Cancer” Journal of Nanoscience and Nanotechnology, 15, 7971-7975 (2015). doi:10.1166/jnn.2015.11233

Y. Kotsuchibashi, M. Ebara, T. Sato, Y. Wang, R. Rajender, D.G. Hall, R. Narain, T. Aoyagi. “Spatiotemporal Control of Synergistic Gel Disintegration Consisting of Boroxole- and Glyco-Based Polymers via Photoinduced Proton Transfer” Journal of Physical Chemistry B, 119(6), 2323-2329 (2015). doi:10.1021/jp506478p

Y. Kotsuchibashi, M. Ebara, A.S. Hoffman, T. Aoyagi. “Temperature-responsive mixed core nanoparticle properties determined by the composition of statistical and block copolymers in the core” Polymer Chemistry, 6, 1693-1697 (2015). doi:10.1039/C4PY01794C

Y. Wang, Y. Kotsuchibashi, K. Uto, M. Ebara, T. Aoyagi, Y. Liu, R. Narain. “pH and glucose responsive nanofibers for the reversible capture and release of lectins” Biomaterials Science, 3, 152-162 (2015). doi:10.1039/C4BM00269E

(総説・著書など)

栗本理央,高井僚,小土橋陽平,荏原充宏, “災害時に透析患者を救うナノファイバーの開発”, 特集1/メディカル:進化する医療技術・医療材料, WEB Journal, 10, 7-9(2015).

M. Ebara. “Shape-memory surfaces for cell mechanobiology” Science and Technology of Advanced Materials, 16(1), 014804 (2015). doi:10.1088/1468-6996/16/1/014804

新山瑛理, 中川泰宏, 荏原充宏, “免疫反応を制御する高分子材料の設計”, 特集:免疫系とバイオマテリアル, 生体材料, 33(2), 144-153 (2015).

荏原充宏, “スマートポリマーを用いた細胞メカノバイオロジー”,高分子科学最近の進歩, 高分子, 64, 272-276 (2015).

荏原充宏, “スマートポリマー:細胞メカノバイオロジーに貢献する細胞培養ツール”, トピックス, B&I, シーエムシー出版, 73(2), 102-103 (2015).

荏原充宏, “空気がよめる細胞たち”, 目で見るバイオ, B&I, シーエムシー出版, 73(2), 129-130 (2015).

荏原充宏, 李千萬. “がんと闘うナノファイバー”, NIMS NOW, No.15, 7-9, (2015).→こちら

荏原充宏, “生分解性形状記憶ポリマー”, 進化する医療用バイオベースマテリアル, シーエムシー出版, 第5編25章, 244-250 (2015). ISBN: 978-4-7813-1054-1

2014年

(原著論文)

M. Ebara, M. Akimoto, K. Uto, K. Shiba, G. Yoshikawa, T. Aoyagi. “Focus on the interlude between topographic transition and cell response on shape-memory surfaces” Polymer, 55, 5961-5968 (2014). doi: http://dx.doi.org/10.2147/IJN.S50677

Q. Shou, K. Uto, W.-C. Lin, T. Aoyagi, M. Ebara. “Near-infrared-lrradiation-induced remote activation of surface shape-memory to direct cell orientations” Macromolecular Chemistry and Physics, 215, 2473-2481 (2014). doi:10.1002/macp.201400353

M. Ebara, T. Aoyagi. “Photo-induced Control of Smart Polymer Systems via pH Jump Reaction” Journal of Photopolymer Science and Technology, 27(4), 467-469 (2014). doi:http://dx.doi.org/10.2494/photopolymer.27.467

M. Ebara, K. Uto, N. Idota, T. Aoyagi. “The Taming of The Cell: Shape-memory Nanopatterns Direct Cell Orientation” International Journal of Nanomedicine, 9, 117-126 (2014). doi: http://dx.doi.org/10.2147/IJN.S50677

Q. Shou, K. Uto, M. Iwanaga, M. Ebara, T. Aoyagi. “Near infrared light-responsive shape memory poly(e-caprolactone) films that actuate in physiological temperature range” Polymer Journal, 46, 492-498 (2014). doi: 10.1038/pj.2014.48

K. Namekawa, M. Tokoro Schreiber, T. Aoyagi, M. Ebara. “Fabrication of zeolite-polymer composite nanofibers for removal of uremic toxins from kidney failure patients” Biomaterials Science, 2, 674-679 (2014). 表紙に掲載 doi:10.1039/C3BM60263J

D. Mosqueira, S. Pagliari, K. Uto, M. Ebara, S. Romanazzo, C. Escobedo-Lucea , J. Nakanishi, A. Taniguchi, O. Franzese, P. D. Nardo, M. José Goumans, E. Traversa , P. Pinto-do-Ó, T. Aoyagi, G. Forte. “Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure” ACS NANO, 8(3), 2033-2047 (2014). doi:10.1021/nn4058984

K. Uto, M. Ebara, T. Aoyagi. “Temperature-responsive poly(e-caprolactone) cell culture platform with reversibly tunable nano-roughness and elasticity for control of myoblast morphology” International Journal of Molecular Science, 15(1), 1511-1524 (2014). doi:10.3390/ijms15011511

T. Omura, M. Ebara, J. J. Lai, X. Yin, A. S. Hoffman, P. S. Stayton, “Design of smart nanogels that respond to physiologically relevant pH values and temperatures”. Journal of Nanoscience and Nanotechnology, 14, 2557-2562 (2014). doi: http://dx.doi.org/10.1166/jnn.2014.8551

 

(総説・著書など)

荏原充宏, “貼る癌治療への挑戦”, 特集医療と健康を考える, CROSS T&T, 48, 23-26 (2014).

K. Ariga, K. Kawakami, M. Ebara, Y. Kotsuchibashi, Q. Ji, J. P. Hill “Bioinspired nanoarchitectonics as emerging drug delivery systemst” New Journal of Chemistry, 38, 5149-5163 (2014). 表紙に掲載 doi:10.1039/C4NJ00864B

荏原充宏, 宇都甲一郎, “形状記憶ゲル”, ゲルテクノロジーハンドブック, エヌ・ティー・エス, 第1編4章4節, 126-131 (2014). ISBN: 978-4-86469-074-4

荏原充宏, 青柳隆夫, “スマートゲルのバイオサイエンスへの応用”, ゲルテクノロジーハンドブック, エヌ・ティー・エス, 第4編5章3節, 769-774 (2014). ISBN: 978-4-86469-074-4

荏原充宏, 宇都甲一郎, “磁性粒子含有ナノファイバーを用いた癌の温熱/化学療法”, 金属,vol.84, No.9, 25-31 (2014).表紙に掲載

荏原充宏, “Emerging MANA Researcher”, Convergence, No.17, 6, (2014).裏表紙に掲載→こちら

荏原充宏, “貼るがん治療―抗がん活性を有するナノファイバーメッシュの開発”, 特別企画/加工ガイド2015, 紙パルプ技術タイムス, 86-89 (2014).

荏原充宏, “スマートポリマーの医療応用”, 特集:機能性新素材, 成型加工, vol.26, No.8, 376-381 (2014).

荏原充宏, “指で温めて病原体を検出するスマート診断システム”, 機能材料, 34(7), 46-52 (2014).

蟹江慧, 荏原充宏, 加藤竜司, “生体分子・高分子を用いたバイオマテリアルの開発〜細胞と化学の狭間に秘められた可能性〜”, 化学, vol.69, No.6, 68-69 (2014).

荏原充宏, “貼るがん治療〜がんの局所再発防止のためのスマートナノファイバーの開発〜”, 月刊せんい, vol.67, No.5, 303-307 (2014).

荏原充宏, “ナノファイバメッシュ”, 応用物理, 83(1), 52-55 (2014).

荏原充宏, “貼るがん治療”〜抗がん活性を有するナノファイバーメッシュの開発〜”, Nonwoven Review, 24(4), 11-14 (2014).

Y. Kotsuchibashi, M. Ebara, Ravin Narain “Chapter 12 Silica Nanoparticle Bioconjugates.”  Characterization, and Biomedical Applications, Edited by R. Narain, Wiley, 327-343 (2014). ISBN: 978-1-118-35914-3

M. Ebara “Chapter 14 Cell-Based Bioconjugates.”  Characterization, and Biomedical Applications, Edited by R. Narain, Wiley, 327-343 (2014). ISBN: 978-1-118-35914-3

2013年

(原著論文)

Y. Kotsuchibashi, Y. Wang, Y.-J. Kim, M. Ebara, T. Aoyagi, R. Narain “Simple coating with pH-responsive polymer-functionalized silica nanoparticles of mixed sizes for controlled surface properties”ACS Applied Materials & Interfaces, 5, 10004-10010 (2013). doi:10.1021/am403007f

C. Jiang, H. Takehara, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki, “Evaluation of microvalves developed for point-of-care testing devices using shape-memory polymers”J. Photopolymer Sci. Technol., 26, 581-585 (2013). doi:10.2494/photopolymer.26.581

Y.-J. Kim, M. Ebara, T. Aoyagi. “A smart hyperthermia nanofiber with switchable drug release for inducing cancer apoptosis”Adv. Func. Mater., 23, 5753-5761 (2013). doi: 10.1002/adfm.201300746

H. Takehara, C. Jiang, K. Uto, M. Ebara, T. Aoyagi, T. Ichiki “Novel microfluidic valve technology based on shape memory effect of poly(e-caprolactone)”Appl. Phys. Express, 6, 037201 (2013). doi:10.7567/APEX.6.037201

M. Ebara, J. M. Hoffman, A. S. Hoffman, P. S. Stayton, J. J. Lai “A photo-induced nanoparticle separation in microchannels via pH-sensitive surface traps” Langmuir,29, 5388-5393 (2013). doi:10.1021/la400347r

T. Okada, K. Uto, M. Sasai, C. M. Lee, M. Ebara, T. Aoyagi “Nano-decoration of Hemagglutinating Virus of Japan Envelope (HVJ-E) using layer-by-layer assembly technique” Langmuir, 29(24), 7384-7392 (2013). doi:10.1021/la304572s

T. Sato, M. Ebara, S. Tanaka, T.-A. Asoh, A. Kikuchi, T. Aoyagi “Rapid self-healable poly(ethylene glycol) hydrogels formed by selective metal–phosphate interactions” Physical Chemistry Chemical Physics, 15, 10628-10635 (2013).doi:10.1039/c3cp50165e

M. Ebara, K. Uto, N. Idota, J. M. Hoffman, T. Aoyagi “Rewritable and shape-memory soft matter with dynamically tunable microchannel geometry in a biological temperature range” Soft Matter, 9, 3074-3080 (2013). doi:10.1039/c3cp50165e

Y. Kotsuchibashi, Y. Zhang, M. Ahmed, M. Ebara, T. Aoyagi, R. Narain “Fabrication of FITC-doped silica nanoparticles and study of their cellular uptake in the presence of lectins” J Biomed Mater Res Part A, 101A, 2090-2096 (2013). doi:10.1088/1468-6996/13/6/064207

(総説・著書など)

荏原充宏, “温熱療法と化学療法を同時におこなえるナノファイバーメッシュを開発”, NIMS NOW, No.10, 10-11, (2013).表紙に掲載 こちら

荏原充宏, “ナノファイバーメッシュを用いた温熱・化学療法”, Isotope News, 716, 23-25 (2013).

荏原充宏, “がん治療のためのナノファイバーメッシュの開発”, PHARM TECH JAPAN, 29, 35-38 (2013).

荏原充宏, “飲み忘れも心配なし!?未来の薬”, Convergence, 13, 7 (2013).→こちら

荏原充宏, “抗癌活性を有するナノファイバーメッシュの開発”, 不織布増刊号特集・未来社会を創生するテクノロジーの実用化, WEB Journal, 141, 27-29 (2013).

荏原充宏, “ガンを熱して退治する不織布を開発!”, 子供の科学9月号, 第929号, 6 (2013).

荏原充宏, 化学掲示板, 化学, 化学同人, 68(8), 73, (2013).

荏原充宏, WHO'S WHO, ジャパンナレッジ,小学館, 2013年08月26日配信 (2013).

荏原充宏, “生分解性プラスチックを活用した形状記憶高分子の開発”, 特集・新しい環境対応材料・技術・用途展開, 月刊Polyfile, 50(594), 32-35 (2013).

荏原充宏, 宇都甲一郎, 青柳隆夫 “基材の構造力学的性質による細胞機能の制御”, 特集 細胞接着の制御 生体の科学, 64, 194-198 (2013).

荏原充宏, 宇都甲一郎, 青柳隆夫 “生分解性高分子”, 再生医療叢書2 組織工学, 岡野光夫・大和雅之編集, 朝倉書店、1-24, (2013).

荏原充宏, 齋藤充弘 “免疫反応を制御可能な未来型バイオマテリアルの設計―Immunobioengineering”, Drug Delivery System、日本DDS学会、28-2, 135-148 (2013).

G. Forte, S. Pagliari, F. Pagliari, M. Ebara, P. D. Nardo, T. Aoyagi “Toward the generation of patient-specific patches for cardiac repair” Stem Cell Reviews and Reports, 9(3), 313-325 (2013). doi:10.1007/s12015-011-9325-8

 

2012年

(原著論文)

S. Romanazzo, G. Forte, M. Ebara, K. Uto, S. Pagliari, T. Aoyagi, E. Traversa, A. Taniguchi “Substrate Stiffness affects skeletal myoblast differentiation in vitro” Science and Technology of Advanced Materials, 13, 064211 (2012). doi:10.1088/1468-6996/13/6/064211

K. Uto, T. Muroya, M. Okamoto, H. Tanaka, T. Murase, M. Ebara, T. Aoyagi “Design of super-elastic biodegradable scaffolds with longitudinally-oriented microchannels and optimization of the channel size for Schwann cells migrations” Science and Technology of Advanced Materials, 13, 064207 (2012). doi:10.1088/1468-6996/13/6/064207

N. Idota, M. Ebara, Y. Kotsuchibashi, R. Narain, Aoyagi “Novel temperature-responsive polymer brushes with carbohydrate residues facilitate selective adhesion and collection of hepatocytes” Science and Technology of Advanced Materials, 13, 064206 (2012). doi:10.1088/1468-6996/13/6/064206

J. K. V. Tam, K. Uto, M. Ebara, S. Pagliari, G. Forte, T. Aoyagi “Mesenchymal stem cell adhesion but not plasticity is affected by high substrate stiffness” Science and Technology of Advanced Materials, 13, 064205 (2012). doi:10.1088/1468-6996/13/6/064205

Y.-J. Kim, M. Ebara, T. Aoyagi “Temperature-responsive electrospun nanofibers for 'on-off' switchable release of dextran” Science and Technology of Advanced Materials, 13, 064203 (2012). doi:10.1088/1468-6996/13/6/064203

P. Techawanitchai, N. Idota, K. Uto, M. Ebara, T. Aoyagi “A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction” Science and Technology of Advanced Materials, 13, 064202 (2012). doi:10.1088/1468-6996/13/6/064202

Y.-J. Kim, M. Ebara, T. Aoyagi “A smart nanofiber web that captures and release cells” Angewandte Chemie International Edition, 51, 10537-10541 (2012). doi:10.1002/anie.201204139

G. Forte, S. Pagliari, M. Ebara, K. Uto, J. K. V. Tam, S. Romanazzo, C. Escobedo-Lucea, E. Romano, P. D. Nardo, E. Traversa, T. Aoyagi “Substrate stiffness modulates gene expression and phenotype in neonatal cardiomyocytes in vitro” Tissue Engineering Part A, 18, 1837-1848 (2012).doi:10.1089/ten.tea.2011.0707

Y. Kotsuchibashi, M. Ebara, T. Aoyagi, R. Narain “Fabrication of dual-responsive polymer functionalized silica nanoparticles via a simple thiol-ene click chemistry” Polymer Chemistry, 3, 2545-2550 (2012).doi:10.1039/C2PY20333B

Y. Kotsuchibashi, M. Ebara, N. Idota, R. Narain, T. Aoyagi “A ‘smart’ approach towards the formation of multifunctional nano-assemblies by simple mixing of block copolymers having a common temperature sensitive segment” Polymer Chemistry, 3, 1150-1157 (2012).doi:10.1039/C2PY00589A

P. Techawanitchai, M. Ebara, N. Idota, T.-A. Asoh, A. Kikuchi, T. Aoyagi “Photo-switchable control of pH-responsive actuators via pH jump reaction” Soft Matter, 8, 2844-2851 (2012). doi:10.1039/C2SM07277G

M. Ebara, K. Uto, N. Idota, J. M. Hoffman, T. Aoyagi “Shape-memory surface with dynamically tunable nano-geometry activated by body heat”, Advanced Materials, 24, 273-278 (2012). doi:10.1002/adma.201102181

P. Techawanitchai, M. Ebara, N. Idota, T. Aoyagi “Light-induced spatial control of pH-jump reaction at smart gel interface” Colloids and Surfaces B: Biointerfaces, 99, 53-59 (2012).  doi:10.1016/j.colsurfb.2011.09.039

(総説・著書など)

K. Kawakami, M. Ebara “Chapter 10 Nanotechnology in Drug Delivery Systems” Manipulation of Nanoscale Materials, 242-258 (2012). doi:10.1039/9781849735124-00242

荏原充宏, “スマートポリマーを用いた途上国医療への取り組み”, 高分子論文集、高分子学会、69(10), 545-554 (2012).ISSN: 1881-5685

K. Kawakami, M. Ebara, H. Izawa, N. M. Sanchez-Ballester, J. P. Hill, K. Ariga “Supramolecular approaches for drug development” Current Medicinal Chemistry, 19(15), 2388-2398 (2012).ISSN: 0929-8673

荏原充宏, 青柳隆夫 “スマートバイオマテリアルの応用”, ケミカルエンジニアリング、化学工業社57(4), 31-36 (2012).

荏原充宏, “環境応答ゲル”, わかりやすい透析工学、南江堂、176-183 (2012).

荏原充宏, “スマートゲル表面 特集スマートゲルの最新動向”, 機能材料、32(3), 6-12 (2012).

荏原充宏, “世界の子供達の命をつなぐナノ・リンカー”, NIMS NOW, 4, 2 (2012).→こちら

 

2011年

(原著論文)

P. Techawanitchai, K. Yamamoto, M. Ebara, T. Aoyagi “Surface design with self-heating smart polymers for on-off switchable trap” Science and Technology of Advanced Materials, 12, 044609 (2011).表紙に掲載  doi:10.1088/1468-6996/12/4/044609

Y. Kotsuchibashi, M. Ebara, K. Yamamoto, T. Aoyagi “Tunable stimuli-responsive self-assembly system that forms and stabilizes nanoparticles by simple mixing and heating/cooling of selected block copolymers” Polymer Chemistry, 2, 1362–1367 (2011). doi:10.1039/C1PY00004G

H. Yagi, M. Ebara. K. Yamamoto, T. Aoyagi, "Effect of grafted smart polymer architectures on interaction with hydrophobic molecules in newly developed induction heating chromatography system", Materials Science and Engineering C, 31,  1681-16875 (2011). doi:10.1016/j.msec.2011.07.018

(総説・著書など)

M. Ebara “Carbohydrate-derived Hydrogels and Microgels.” Engineered Carbohydrated-based Materials For Biomedical Applications Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels, Edited by R. Narain, Wiley, 337-354, (2011). ISBN: 978-0-470-47235-4

荏原充宏, “形状記憶インターフェイスを用いた細胞運命の時間・空間操作”, Colloid & Interface Communication、36(4), 23-24 (2011).


2006-2010年

(原著論文)

Y. Kotsuchibashi, M. Ebara, K. Yamamoto, T. Aoyagi “On–off switching of dynamically controllable self-assembly formation of double-responsive block copolymers with tunable LCSTs” Journal of Polymer Science Part A: Polymer Chemistry, 48, 20, 4393–4399 (2010). doi:10.1002/pola.24226



J. M. Hoffman, M. Ebara, J. J. Lai, A. Folch, A. S. Hoffman, P. S. Stayton “A helical flow, circular microreactor for separating and enriching ‘‘smart’’ polymer–antibody capture reagents”, Lab on a Chip, 10, 3130-3138 (2010). doi:10.1039/C004978F

V. Kekkonen, N. Lafreniere, M. Ebara, A. Saito, Y. Sawa, R. Narain “Synthesis and characterization of biocompatible magnetic glyconanoparticles.” Journal of Magnetism and Magnetic Materials, 321, 1393-1396 (2009). doi:10.1016/j.jmmm.2009.02.045

M. Ebara, M. Yamato, T. Aoyagi, A., K. Sakai,, T. Okano, “ A Novel Approach to Observing Synergy Effects of PHSRN on Integrin–RGD Binding Using Intelligent Surfaces”, Advanced Materials, 20, 3034-3038 (2008).doi:10.1002/adma.200702308

M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai, T. Okano, "The effect of extensible PEG tethers on shielding between grafted thermo-responsive polymer chains and integrin–RGD binding", Biomaterials, 29, 3650–3655 (2008).doi:10.1016/j.biomaterials.2008.05.030

M. Ebara, J. M. Hoffman, P. S. Stayton, A. S. Hoffman. “Surface modification of microfluidic channels by UV-mediated graft polymerization of non-fouling and ‘smart’ polymers.” Radiation Physics and Chemistry, 76, 1409-1413 (2007).doi:10.1016/j.radphyschem.2007.02.072

J. J. Lai, J. M. Hoffman, M.  Ebara, A. S. Hoffman, C. Estournes, A. Wattiaux, P. S. Stayton. “Dual magnetic-/temperature-responsive nanoparticles for microfluidic separations and assays.” Langmuir, 23, 7385-7391 (2007).doi:10.1021/la062527g

M. Ebara, J. M. Hoffman, A. S. Hoffman, P. S. Stayton. “Switchable surface traps for injectable bead-based chromatography in PDMS microfluidic channels.” Lab on a Chip, 6, 843-848 (2006). doi:10.1039/B515128G   (表紙に掲載)

K. Morishima, Y. Tanaka, M. Ebara, T. Shimizu, A. Kikuchi, M. Yamato, T. Okano, T. Kitamori. “Demonstration of a bio-microactuator powered by cultured cardiomyocytes coupled to hydrogel micropillars.” Sensors and Actuators B, 119, 345-350 (2006). doi:10.1016/j.snb.2005.11.063

(総説・著書など)

 荏原充宏, “スマート界面” 日本バイオマテリアル学会監修“バイオマテリアルの基礎”、138-142 (2010).

荏原充宏,, “スマートゲルのバイオサイエンスへの応用” 特集ゲル―最新の機能性材料―, 化学工学、74(7), 335-337 (2010). 表紙に掲載

荏原充宏, “環境応答ゲル”食品・化粧品・医療分野へのゲルの利用、シーエムシー出版, 178-185 (2010).

荏原充宏, “ウィキ・テクノロジー”, バイオマテリアル-生体材料-、28(3), 161-162 (2010).

荏原充宏,“スマート界面”、バイオマテリアル, 27(3), 172-179(2009).

2005年以前

(原著論文)

M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai, T. Okano, "Temperature-Responsive Cell Culture Surfaces Enable "On-Off" Affinity Control between Cell Integrins and RGDS Ligands ", Biomacromolecules, 5, 505-510 (2004).doi:10.1021/bm0343601

M. Ebara, M. Yamato, T. Aoyagi, A. Kikuchi, K. Sakai, T. Okano, "Immobilization of Cell Adhesive Peptides to Temperature-responsive Surfaces Facilitates Both Serum-free Cell Adhesion and Non-Invasive Cell Harvest", Tissue Engineering, 10(7-8), 1125-35 (2004). doi:10.1089/ten.2004.10.1125

M. Ebara, M. Yamato, S. Nagai, T. Aoyagi, A. Kikuchi, K. Sakai, T. Okano, "Incorporation of new carboxylate functionalized co-monomers to temperature-responsive polymer-grafted cell culture surfaces”, Surface Sciences, 570, 134-141(2004). doi:10.1016/j.susc.2004.06.183

M. Ebara, M. Yamato, M. Hirose, T. Aoyagi, A. Kikuchi, K. Sakai and T. Okano, "Copolymerization of 2-Carboxyisopropylacrylamide with N-Isopropylacrylamide Accelerates Cell Detachment from Grafted Surfaces by Reducing Temperature”, Biomacromolecules, 4, 344-349 (2003).doi:10.1021/bm025692t

M. Ebara, T. Aoyagi, K. Sakai and T. Okano, "The incorporation of carboxylate groups into temperature-responsive poly(N-isopropylacrylamide)-based hydrogels promotes rapid gel shrinking," Journal of Polymer Science, Polymer Chemistry, 39, 335-342 (2001).doi:10.1002/1099-0518(20010201)39:3<335::AID-POLA1000>3.0.CO;2-H

表紙に掲載

M. Ebara, T. Aoyagi, K. Sakai and T. Okano, "Introducing reactive carboxyl side chains retains phase transition temperature-sensitivity in N-isopropylacrylamide copolymer gels", Macromolecules, 33, 8312-8316 (2000).doi:10.1021/ma000121j

T. Aoyagi, M. Ebara, K. Sakai, Y. Sakurai and T. Okano, "Novel bifunctional polymer with reactivity and temperature sensitivity", Jounal of Biomaterials Sciences, Polymer Edition, 11, 101-110 (2000).doi:http://dx.doi.org/10.1163/156856200743526

荏原充宏、青柳隆夫、酒井清孝、岡野光夫, "新規温度応答性ハイドロゲルの薬物放出デバイスへの展開", 医工学治療, 12(4), 877-883 (2000).

(総説・著書など)

荏原充宏, 大和雅之, 菊池明彦, 酒井清孝, 岡野光夫, ‘細胞シート工学のためのインテリジェント培養皿の開発’ 生物工学会誌、81, 478-480 (2003).

荏原充宏、‘体外での組織再生のための新規培養皿の設計’ 日本工業新聞, 2003年7月10日号第8面.

M. Ebara, A. Kikuchi, K. Sakai, T. Okano. “Section III. Synthetic Systems 2. Chapter 12 Fast Shrinkable Materials.” Reflexive Polymers and Hydrogels: Understanding and Designing Fast Responsive Polymeric Systems, Edited by N. Yui, R. J. Mrsny, and K. Park, CRC Press Inc., 219-244, (2004).