MANA Research Highlight

MANA Research Highlight Vol. 3

July 26, 2012

Development of hybrid porous scaffolds for promoted bone regeneration

Enhanced osteoinductivity through mimicking the in vivo micro-environment

A hybrid porous scaffold with enhanced osteoinductivity has been successfully developed by a collaboration team from Tissue Regeneration Materials Unit, International Center for Materials Nanoarchitectonics of National Institute for Materials Science, Nano Medical Engineering Laboratory of RIKEN and National Research Institute for Child Health and Development. The hybrid scaffold was prepared from a mechanical strong synthetic poly(lactic-co-glycolic acid), collagen and a fusion bone morphogenetic protein-4 composed of an additional collagen-binding domain to mimic the nano- and micro-environment surrounding cells in vivo. The hybrid scaffold showed high osteoinductivity and will be used for regeneration of large bone. The hybridization method can also be used to prepare hybrid porous scaffolds with other cell growth factors for promoted regeneration of other tissues such as cartilage and skin.

Fig.1

Further information

Publications and Affiliation:

Hongxu Lu1, Naoki Kawazoe1, Takashi Kitajima2, Yuka Myoken3, Masahiro Tomita3, Akihiro Umezawa4, Guoping Chen1*, Yoshihiro Ito2* Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity. Biomaterials, 33, 6140-6146, (2012).

  1. Tissue Regeneration Materials Unit, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
  2. Nano Medical Engineering Laboratory, RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako 351-0198, Japan
  3. Neosilk Laboratory, Immuno-Biological Laboratories Co., Ltd., 3-13-60 Kagamiyama, Higashihiroshima, Hiroshima 739-0046, Japan
  4. National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan

* corresponding authors

Contact information

International Center for Materials Nanoarchitectonics(WPI-MANA)

1-1 Namiki, Tsukuba-shi Ibaraki, 305-0044 Japan
Email: Guoping Chen, Ph.D<Guoping.CHENnims.go.jp>
Telephone: +81-29-860-4496

About MANA

http://www.nims.go.jp/mana/