• Graduate School of Life Science, Hokkaido University
  • Recruitment for Collaborative Research
  • Mterials

 

Publications

2017

【Original Papers】
  1. Manoharan AK., Chinnathambi S., Jayavel R., Hanagata N. Simplified detection of the hybridized DNA using a graphene field effect transistor. Science and Technology of Advanced Materials 18.1: 43-50 (2017)
  2. Chinnathambi S. , Abu N., Hanagata N. Biocompatible CdSe/ZnS quantum dot micelles for
    long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin. RSC Advances 7.2392 (2017)
  3. Liang T., Xie S., Huang Z., Fu W., Ca, Y., Yan, X., Chen H., Ma X., Iwai H., Fujit, D., Hanagata N., X, M. Elucidation of Zero-Dimensional to Two-Dimensional Growth Transition in MoS2 Chemical Vapor Deposition Synthesis. Advanced Materials Interfaces 4.4:1600687 (2017)
  4. Yao X., Tian Z., Liu J., Zhu Y., Hanagata N. Mesoporous Silica Nanoparticles Capped with Graphene Quantum Dots for Potential Chemo−Photothermal Synergistic Cancer Therapy. LANGMUIR 33: 591-599 (2017)
【Books】
  1. 花方信孝　「ナノテクノロジーで花粉症を治せるか？」 コロナ社 (2017)

2016

【Original Papers】
  1. Chen S., Du X., Jia L., Chang H., Ikoma T., Hanagata N. Synthesis and osteo-compatibility of novel reduced graphene oxide–aminosilica hybrid nanosheets. Materials Science and Engineering C : 61: 251–256 (2016)
  2. Chinnathambi S., Karthikeyan S., Kesherwani M., Velmurugan D., Hanagata N. Underlying the Mechanism of 5-Fluorouracil and Human Serum Albumin Interaction: A Biophysical Study. Journal of Physical Chemistry & Biophysics 6: 2 (2016)
  3. Chen MH., Hanagata N., Ikoma T., Huang JY., Li KY., Lin CP., Lin FH. Hafnium-doped hydroxyapatite nanoparticles with ionizing radiation for lung cancer treatment.Acta Biomaterialia 37: 165-173 (2016)
  4. Xu Y., Zhu Y., Li X., Morita H., Hanagata N. Investigation of dendritic mesoporous silica
    nanoparticles for cytosine-phosphate-guanosine oligodeoxynucleotide delivery.Materials Express 6. 2: 116-126 (2016)
  5. Hirata E., Miyako E., Hanagata N., Ushijima N., Sakaguchi N., Russier J., Yudasaka M., Iijima S. Biancof A., Yokoyama A. Carbon nanohorns allow acceleration of osteoblast differentiation via macrophage activation. Nanoscale 8. 14514 (2016)
【Invited Lectures】
  1. 花方信孝　「難治性骨疾患の原因遺伝子とその治療戦略」 つくば医工連携フォーラム2016、国立研究開発法人産業技術総合研究所、1月22日(2016)
  2. 花方信孝　「網羅的遺伝子発現解析の生体材料評価への応用」　日本金属学会2016春期（第158回）大会、 東京理科大学葛飾キャンパス、3月23日-25日(2016)
【International Conferences】
  1. Chinnathambi S., Hanagata N., Functionalized Near-Infrared Quantum Dots for Biological Applications. Pharmaceutica 2016, Melia Avenida America, Madrid, Spain. March 7-9 (2016)
  2. Shyong YJ.,. Lin FH., Hanagata N., Calcium Phosphate Induce Exosome Release of Human Monocyte for Exosomal-based Drug Delivery Systems. Nano S&T-2016, Holiday Inn Singapore Atrium, Singapore. October 26-28 (2016)
  3. Chinnathambi S., Hanagata N., Binding characteristics of phospholipid coated magnetic CdSe/ZnS quantum dot micelles with human serum albumin. Nano S&T-2016, Holiday Inn Singapore Atrium, Singapore. October 26-28 (2016)
  4. Chinnathambi S., Hanagata N., Superparamagnetic CdSe/ZnS Quantum Dot Micelles for Cancer Cell Imaging. 10th Anniversary International Symposium on Nanomedicine (ISNM2016), AIST,Tsukuba, Japan. November 24-26(2016)
  5. Chen MH., Minowa T., Li X., Takemura T., Hanagata N., Dissolving Microneedles As a Transdermal Delivery System for Adjuvant CpG DNA. 10th Anniversary International Symposium on Nanomedicine (ISNM2016), AIST,Tsukuba, Japan. November 24-26(2016)
  6. Shyong YJ.,. Lin FH., Hanagata N.,Calcium phosphateinduce exosome release of human monocyte for exosomal-based drug delivery system. 10th Anniversary International Symposium on Nanomedicine (ISNM2016), AIST,Tsukuba, Japan. November 24-26(2016)
  7. Chinnathambi S., Hanagata N., Superparamagnetic CdSe/ZnS Quantum Dot Micelles for Cancer Cell Imaging. Advanced materials conference (AMC2016), Bayview Hotel Langkawi,I, Kedah, Malaysia, November 28-29 (2016)
  8. Chen MH., Minowa T., Li X., Takemura T., Hanagata N., Dissolving Microneedles As a Transdermal Delivery System for Adjuvant CpG DNA. Advanced materials conference (AMC2016), Bayview Hotel Langkawi,I, Kedah, Malaysia, November 28-29 (2016)
  9. Chen MH., Minowa T., Magee A., Li X., Takemura T., Hanagata N., Apatite Nanoparticles-Assisted Dissolving Microneedles for Transdermal Adjuvant CpG DNA Delivery. Advanced materials conference (AMC2016), Bayview Hotel Langkawi,I, Kedah, Malaysia, November 28-29 (2016)

2015

【Original Papers】
  1. Tao C., Zhu Y., Li X., H., Hanagata N. Binding of CpG oligodeoxynucleotides to mesoporous silica nanoparticles for enhancing delivery efficiency. Microporous and Mesoporous Materials 204: 91-98 (2015)
  2. Chinnathambi S., Karthikeyan S., Velmurugan D., Hanagata N., Aruna P., Ganesan S. Investigation on the interaction of 5-Fluorouracil with herring sperm DNA: Steady state/time and molecular modeling studies. Biophysical Reviews and Letters 10: 115-133(2015)
  3. Chinnathambi S., Karthikeyan S., Velmurugan D., Hanagata N., Aruna P., Ganesan S. Effect of Moderate UVC Irradiation on Bovine Serum Albumin and Complex with Antimetabolite 5-Fluorouracil: Fluorescence Spectroscopic and Molecular Modelling Studies. International Journal of Spectroscopy 2015:315764(2015)
  4. Zhang H., Feng S., Zhi C., Gao X., Hanagata N. Polyethyleneimine-functionalized boron nitride nanospheres as efficient carriers for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides. International Journal of Nanomedicine 2015:10 :5343-5353
  5. Maeda S., Morikawa T., Takadate T., Suzuki T., MINOWA T., HANAGATA N., Onogawa T., Motoi F., Nishimura T., Unno M. Mass spectrometry-based proteomic analysis of formalin-fixed paraffinembedded extrahepatic cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Sciences 22 : 683-691(2015)
  6. Hanagata N., Morita H. Calcium Ions Rescue Human Lung Epithelial Cells from the Toxicity of Zinc Oxide Nanoparticles. The Journal of Toxicological Sciences  40. 5 : 625-635 (2015)
  7. Xu L., Dan M., Shao A., Cheng X., Zhang C., Yoke R., Takemura T., Hanagata N., Niwa M., Watanabe D. Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model. International Journal of Nanomedicine 2015:10 : 6105-6119 (2015)
  8. Chinnathambi S., Pi X., Xu M.., Hanagata N. Regulation of bifurcated cytokine induction by surface charge of nanoparticles during interaction between CpG oligodeoxynucleotides
    and toll-like receptor 9. Journal of Drug Delivery Science and Technology 29 : 251-260 (2015)
  9. Chen S., Zhang Q., Jia L., Du X., Hanagata N. A facilely controlled length, cytotoxicity, lengthdependent and cell type-dependent cellular uptake of silica nanotubes and their applications in the delivery of immunostimulatory CpG oligodeoxynucleotides. Journal of
    Materials Chemistry B     : 3:7246-7254 (2015)
  10. Xu Y., Claiden P., Zhu Y., Morita H., Hanagata N. Effect of amino groups of mesoporous silica nanoparticles on CpG oligodexynucleotide delivery. JScience and Technology of Advanced Materials 16 : 045006 (2015)
  11. Shiba K., Tagaya M., Sugiyama T., Hanagata N.Synthesis and osteo-compatibility of novel reduced graphene oxide–aminosilica hybrid nanosheets. RSC Advances : 5: 104343-104353 (2015)
  12. Hanagata N. IFITM5 mutations and osteogenesis imperfecta. Journal of Bone and Mineral Metabolism : 34: 123-131 (2015)
 
【International Conferences】
  1. Chen S., Hanagata N., Wu J., Osaka A.Synthesis of hollow silica flowers and titania nano-flowers for biomedical applications. 39th International Conference and Expo on Advanced Ceramics and Composites (ICACC) 2015, Daytona Beach, FL. January 25-30(2015)
  2. Chen MH., Takemura T., Minowa T., Ikoma T., Tanaka J., Lin FH., Hanagata N. Enhancing CpG-DNA delivery for cancer immunotherapy by calcium phosphate nanoparticles. The 5th Asian Biomaterials Congress(2015ABMC5), Chientan Youth Activity Center, Taipei, May 6-9 (2015)
  3. Chinnathambi S., Hanagata N. CpG ODN Delivery using Silicon Quantum Dots. The 5th Asian Biomaterials Congress(2015ABMC5), Chientan Youth Activity Center, Taipei, May 6-9 (2015)
  4. Sode K., Shiota M., Yamazaki T., Yamashita Y., Hirose N., Kojima K., Tsugawa W. Insight into the Intra-Molecular Electron Transfer in the FAD Dependent Dehydrogenase Complex. 13th Int. Symposium on Bioelectrochemistry and Bioenergetics, Malmo University, Malmo, Sweden, June 14-18 (2015)
  5. Yamazaki T., Mikami A. Biological functionalization of stainless steel surface with synthetic peptides. Internatinoal syposium on nanoarchitectonics for mechanobiology, NIMS, Tsukuba, Japan, July 29-30 (2015)
  6. Yamazaki T. G-quadruplex structure improved immunostimulatory effects of CpG oligo deoxynucleotides. Advanced Materials World Congress, Viking Line, Stockholm, Sweden, August 23-26 (2015)
  7. CHEN1 S., Hanagata N., OSAKA A. Silica in nano-fibers, nano-particles, and macrospheres for biomedical applications. 11th IUPAC International Conference on Novel Materials and their Synthesis (NMS-XI), Yanshan University, Qinhuangdao, China, October 11-16 (2015)
  8. Yamazaki T., Suwarti, Hanagata N. Recognition of CpG olygodeoxynucleotides by human Toll-like receptor 9. Toll 2015, Palacio de Congresos de Mabella, Mabella, Spain, September 30-October 3 (2015)
  9. Chinnathambi S., Hanagata N. Micelle Encapsulated Magnetic Core/Shell Quantum Dots for Biological Applications. 9th International Symposium of Nanomedicine. Mie University, Mie, December 10-12(2015)
  10. Manoharan AK., Chinnathambi S., Jayavel R., Hanagata N.The Electrophoretic study to detect the DNA hybridization using monolayer graphene based field effect transistor. 9th International Symposium of Nanomedicine. Mie University, Mie, December 10-12(2015)
  11. Shiota M., Kojima K., Tsugawa W., Yamazaki T., Stefano F., Sode K., The iron-sulfur cluster is conserved in the datalytic subunits of drect electron transfer type FAD dependent dehydrogenase complexes. 2015 Internatonal Chemical Congress of Pacific Asin Societies, Honolulu, Hawaii, USA, December 15-20 (2015)
 
【Domestic Conferences】
  1. 山崎智彦　「細胞制御のための人工生体分子の開発」 第4回NIMS講演会、デンカイノベーションセンター、5月22日(2015)
  2. 山崎智彦、花方信孝　「ペプチドアプタマーを用いた水酸アパタイトの機能化/Functionalization of a hydroxyapatite using screened peptide」　日本セラミックス協会第28回秋季シンポジウム、富山大学、9月16日-18日
  3. 山崎智彦　「CpGオリゴヌクレオチドの免疫活性能に対するポリグアノシンの影響/Poly-guanosine control stimulatory activity of phosphodiester CpG oligonucleotides」 　第67回日本生物工学会大会、城山観光ホテル、鹿児島、10月26日-28日
  4. 山崎智彦、吉慶敏、花方信孝、有賀克彦　「固相トランスフェクションのためのナノ構造シリカシートの開発」、第37回日本バイオマテリアル学会大会、京都テルサ、11月9日-10日（2015）
 
【Invited Lectures】
  1. Hanagata, N. TLR9-Dependent Type I Interferon Induction by Double-Stranded Phosphodiester CpG ODN complex. 9th International Symposium of Nanomedicine. Mie University, Mie, December 10-12(2015)
 
【Invited Review Papers】
  1. 花方信孝 「NIMS分子・物質合成プラットフォーム-イノベーション技術の創出」 工業材料63 (3): 76-78 (2015)
【Books】
  1. 花方信孝　「ナノイムノセラピー　免疫を制御するナノメディシン」　Nano Immunotherapy、コロナ社 (2015)
  2. Hanagata N. Global Gene Expression Analysis for the Assessment fo Nanobiomaterials. Biomaterials for Oral and Craniomaxillofacial Applications 17, 78-89(2015)
  3. 生駒俊之、田中　順三、伊藤　博、芹澤　武、早乙女　進一、花方信孝、吉岡　朋彦、澤田　敏樹、多賀谷　基博　「生物材料・ナノ材料に対する細胞の遺伝子応答」　ナノバイオとナノメディシン、コロナ社：204-245 (2015)

 

2014

【Original Papers】
  1. Ehashi T., Takemura T., Hanagata N., Minowa T., Kobayashi H., Ishihara K., Yamaoka T. Comprehensive genetic analysis of host body reactions to the typical bioactive and bio-inert 3D scaffolds with a same 3D structure. PLoS ONE 9: e85132 (2014)
  2. Chinnathambi S., Chen S., Ganesan S., Hanagata N. Silicon quantum dots for biological application. Advanced Healthcare Materials 3: 10-29 (2014)
  3. Tao C., Zhu Y., Xu Y., Zhu M., Morita H., Hanagata N. Mesoporous silica nanoparticles for enhancing delivery efficiency of CpG oligodeoxynucleotide. Dalton Transaction 43: 5142-5150 (2014)
  4. Chinnathambi S. Velmurugan D., Hanagata N., Aruna P., Ganesan S. Investigations on the interactions of 5-fluorouraci lwith bovine serum album: Optical spectroscopic and molecula rmodeling studies. Journal ofLuminescence 151: 1-10 (2014)
  5. Chen S., Shi X., Osaka A., Gao H., Hanagata N. Facile synthesis, microstructure and BMP-2 delivery of novel silica hollow flowers for enhanced osteoblast differentiation. Chemical Engineering Journal 246: 1-9 (2014)
  6. Chen S., Zhang H., Shi X., Wu H., Hanagata N. Microfluidic generation of chitosan/CpG
    oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties. Lab on a Chip 14: 1842-1849 (2014)
  7. Li X., Hanagata N., Wang X., Yamaguchi M., Yi W., Bando Y., Golberg D. Multimodal luminescent-magnetic boron nitride nanotubes @NaGdF 4:Eu structures for cancer therapy. Chemical Communications 50: 4371-4374 (2014)
  8. Weng Q., Wang B., Wang X., Hanagata N., Li X., Liu D., Wang X., Jiang X., Bando Y., Golberg D. Highly water-soluble, porous and biocompatible boron nitrides for anticancer drug delivery. ACS Nano (in press)
  9. Shiba K., Tagaya M., Hanagata N. Synthesis of Cytocompatible Luminescent Titania/Fluorescein Hybrid Nanoparticles. ACS Applied Materials Interfaces 6 : 6825−6834 (2014)
  10. Yang X., Li J., Tao T., Ma C., Zhang Y., Chen H., Hanagata N., Su H., Xu M. Antibacterial activity of two-dimensional MoS2 sheets. Nanoscale 6: 10126–10133 (2014)
  11. Furlan G., MINOWA T., , Hanagata N. KATAOKA C., KAIZUKA Y. Phosphatase CD45 Both Positively and Negatively Regulates T Cell Receptor Phosphorylation in Reconstituted Membrane Protein Clusters. JOURNAL OF BIOLOGICAL CHEMISTRY : M114.574319 (2014)
  12. Kakinoki S. , Sakai Y., Takemura T., Hanagata N., Fujisato T, Ishihara K., Yamaoka T. Gene chip/PCR-array analysis of tissue response to 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer surfaces in a mouse subcutaneous transplantation system. Journal of Biomaterials Science, Polymer Edition 25, Nos. 14–15: 1658–1672 (2014)
  13. Chen M., Yoshioka T., Ikoma T., Hanagata N., Lin F., Tanaka J. Photoluminescence and doping mechanism of theranostic Eu3+/Fe3+ dual-doped hydroxyapatite nanoparticles. Science and Technology of Advanced Materials 15: 055005 (9pp) (2014)
  14. Tao C., Zhu Y., Li X., H., Hanagata N. Magnetic mesoporous silica nanoparticles for CpG
    delivery to enhance cytokine induction via toll-like receptor 9. RSC Advances 4: 45823-45830 (2014)
【Invited Review Papers】
  1. 花方信孝 「ナノ粒子によるDNAアジュバントの作用制御 －DDSにおけるナノ粒 子の新しい役割－ /Change of action in DNA ajuvant by nanoparticles -a new role of nanoparticles in DDS-」 Medical Science Digest 40 (2): 25-30 (2014)
  2. 花方信孝 「花粉症治療のためのDNAナノメディシン/DNA Nanomedicine for the Treatment of Pollinosis」 ナノ学会会報 12 (2): 45-50 (2014)
  3. 花方信孝 「網羅的遺伝子発現解析によるナノマテリアルの毒性評価 /Assessment of nanotoxicity by global gene expression analysis」 アレルギーの臨床34 (3): 85-88 (2014)
  4. 花方信孝 「ナノ粒子を使ってDNA医薬の作用を操る」 現代科学 4 (517): 44-50 (2014)
【Books】
  1. Chen S., Hayakawa S., Shirosaki Y., Hanagata N., Osaka A. "Biomedical Applications of Sol-Gel Nanocomposites". (Chapter 7 in Sol-Gel Nanocomposites) Springer (2014)
  2. Xu M., Fujita D., Su H., Chen H., Hanagata N. "Analytical Characterization of Nanomaterials in Biological Matrices for Hazard Assessment".(Chapter 8 in Biointeractinos of Nanomaterials) CRC Press (2014)
【Invited Lectures】
  1. Hanagata, N./花方信孝： 「核内タンパク質を標的とした自己免疫抑制 」　分子科学研究所研 究会「細胞核内反応の分子科学]、岡崎コンファレンスセンター、　岡崎市　9月27日　(2014)
  2. Hanagata, N./花方信孝： 「リン酸カルシウムセラミックスの人工骨への応用 」　第15回
    四セラミックス研究機関（ 東工大- 名工大- J F C C - N I M S ） 合同講演会、名古屋工業大学、　名古屋市　10月23日　(2014)
  3. Hanagata N. Regulation of Immunostimulatory DNA Drug Action by Nanoparticles. 7th WCPRM. Chientan Youth Activity Center, Taipei, Taiwan, November 4-7 (2014)
  4. Hanagata, N./花方信孝： 「免疫を制御するDNAナノメディシン 」第3回NIMS講演会、デンカイノベーションセンター、東京都町田市　11月12日　(2014)
【International Conferences】
  1. Chen S., Hanagata N., Osaka A. Micro-engineered Silica Nanotube Membranes for Controlled Cell Behaviors. BIOCERAMICS 26. Hotel Catalonia Barcelona Plaza, Barcelona, Spain. November 6-8 (2014)
  2. Chen MH., TakemuraT., Minowa T., Lin FH, Hanagata N. Hydroxyapatite nanoparticles for enhancing CpG oligodeoxynucleotide delivery in macrophage for cancer immunotherapy.
    7th WCPRM. Chientan Youth Activity Center, Taipei, Taiwan, November 4-7 (2014)
【Domestic Conferences】
  1. Hanagata N. ナノ粒子によるDNAアジュバントの作用制御. 第6回京都SMI産学公連携セミナー、京都大学東京オフィス、 2月25日 (2014)
  2. Kaizuka Y. 細胞膜クラスター形成によるリン酸化シグナルネットワーク制御機構の再構成解析/Reconstitution study of signal regulation in the protein nano clusters. 日本膜学会第36年会、5月12、13日 （2014）
　

2013

【Original Papers】
  1. Suwarti, Yamazaki, T., Chechetka, S., Hanagata, N. Recognition of CpG oligodeoxynucleotides by human Toll-like receptor 9 and subsequent cytokine inducton. Biochemical and Biophysical Research Communications 430: 1234-1239 (2013)
  2. Takadate T, Onogawa T, Fukuda T, Motoi F, Suzuki T, Fujii K, Kihara M, Mikami S, Bando Y, Maeda S, Ishida K, Minowa T, Hanagata N, Ohtsuka H, Katayose Y, Egawa S, Nishimura T, Unno M. Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues.
    International Journal of Cancer 132 (6): 1368-1382 (2013)
  3. Chen C., Shi X., Chinnathambi S., Hanagata, N. Large-scale fabrication of free-standing, micropatterned silica nanotubes via a hybrid hydrogel-templated route. Advanced Healthcare Materials 2: 1091-1095 (2013)
  4. Chen S., Shi X., Chinnathambi S., Wu H., Hanagata N. Generation of microgrooved silica nanotube membranes with sustained drug delivery and cell contact guidance ability using a Teflon microfluidic chip. Science and Technology of Advanced Materials 14. 015005 (2013)
  5. Chen S., Hanagata N. Directing osteoblast alignment and elongation on the micro-grooved silica-based hybrid membrane. Advanced Materials Research 647: 165-169 (2013)
  6. Zhu Y., Shang F., Li B., Dong Y., Liu Y., Lohe MR., hanagata N., Kaskel S. Magnetic mesoporous bioactive glass scaffolds: preparation, physiochemistry and biological properties. Journal of Materials Chemistry B. 1.9. 1279-1288 (2013)
  7. Li X., Xu L., Shao A., Wu G., Hanagata N. Cytotoxic and genotoxic effects of silver nanoparticles on primary syrian hamster embryo (SHE) cells. Journal of Nanotechnology and Nanoscience 13 (1): 161-170 (2013)
  8. Tagaya M., Hanagata N., Ikoma T., Kobayashi T., Shiba K., Yoshioka T., Tanaka J. Cytotoxicity and cancer detection ability of the luminescent nanoporous silica sphere immobilized with folic acid derivative. Key Engineering Materials 529-530: 630-635 (2013)
  9. Zhang H., Chen S., Zhi C., Yamazaki T., Hanagata N. Chitosan-coated boron nitride nanospheres enhance CpG oligodeoxynucleotide delivery and cytokine induction. International Journal of Nanomedicine 8: 1783-1793 (2013)
  10. Shiba K., Tagaya M., Tilley R., Hanagata N. Oxide-based inorganic/organic and nanopourus spherical particles: synthesis and functional properties. Science and Technology of Advanced Materials 14: 023002 (14pp) (2013)
  11. Chen S., Zhang H., Chinnathambi S., Hanagata N. Synthesis of novel chitosan-silica/CpG oligodeoxynucleotide nanohybrids with enhanced delivery efficiency. Materials Science and Engineering C 33: 3382-3388 (2013)
  12. Xu M., Li J., Hanagata N., Su H., Chen H., Fujita D. Challenge to assess the toxic contribution of metal cation released from nanomaterials for nanotoxicology - a case of ZnO nanoparticles. Nanoscale 5: 4763-4769 (2013)
  13. Li X., Zhi C., Hanagata N., Yamaguchi M., Bando Y., Golberg D. Boron nitride nanotubes functionalized with mesoporous silica for intracellular delivery of chemotherapy drugs. Chemical Communications 49: 7337-7339 (2013)
  14. Tsukamoto T., Li X., Morita H., Minowa T., Aizawa T., Hanagata N., Demura M. S-palmitoylation on IFIFT5 undertakes the specific interaction with FKBP11. PLoS ONE 8. 9: e75831 (2013)
  15. Hanagata N. Biological Interpretation of the. In Vitro Assessment of Nanotoxicity. Nano Biomedicine 5 (1): 1-10 (2013)
  16. Zhang J., Zhu Y., Li J., Zhu M., Tao C., Hanagata N. Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials. Science and Technology of Advanced Materials 14: 055009 (2013)
  17. Hanagata N. Recognition of oligodeoxynucleotides by Toll-like receptor 9: Phosphodiester backbone vs. phosphorothioate backbone and monomer vs. multimer. Nano Biomedicine 5: 55-63 (2013)
  18. Chen S., Yoshihara H., Hanagata N., Shirosaki Y., Blevins M., Nakamura Y., Hayakawa S., Stamboulis A., Osaka A. Sol-gel preparation of silica-based nano-fibers for biomedical applications. Ceramic Transactions 242: 55-61 (2013)

【Invited Review Papers】
  1. 花方信孝 「TLR9を介したCpG誘導サイトカインのナノ粒子によるスイッチング/Switch of TLR9 mediated CpG-inducing cytokinesby nanoparticles」 アレルギーの臨床 33: 87-91 (2013)
  2. 花方信孝 「免疫を活性化するDNA医薬のナノ粒子による作用制御/Effect Control of Immunostimulatory DNA Drugs by Nanoparticles」 バイオイン ダストリー 30 :18-26 (2013)
  3. 花方信孝 「免疫活性化DNA医薬のナノ粒子による作用制御/ Control of Immunostimulatory DNA drug action by Nanoparticles」 細胞 45 (12): 35-39 (2013)
【International Conferences】
  1. Hanagata, N. Regulation of bifurcated cytokine induction by binding mode of CpG DNA onto nanoparticles . 5th Immunotherapeutics & Immunomonitoring Conference. The Westin Gaslamp Quarter San Diego, USA. January 31-February 1 (2013)
  2. Yamazaki T., Zhang H., Ikoma T., Hanagata N. Hydroxyapatite-binding peptides.The 7th International Conference on the Science and Technology for Advanced Ceramics. Mielparque-Yokohama,Yokohama, Japan. June 19-21 (2013)
  3. Chen S., Hanagata N. Chitosan-silica nanoparticles for immunostimulatory DNA drug delivery. The 7th International Conference on the Science and Technology for Advanced Ceramics. Mielparque-Yokohama,Yokohama, Japan. June 19-21 (2013)
  4. SAKAI Y., KAKINOKI S., TAKEMURA T., HANAGATA N., FUJISATO T., and YAMAOKA T. Fibroblast growth factor-immobilized polyethylene porous scaffolds via mussel adhesive peptide and heparin for inducing angiogenesis. The 15th International Conference on Biomedical Engineering (ICBME 2013) . National University of Singapore, Singapore. December 4-7 (2013)
  5. Bheema D., Hanagata N. Immunosuppressive DNA Nanomedicine against Autoimmune Disorders. 7th International Symposium on Nanomedicine (ISNM2013). Nakamura Centenary Hall of Kyushu Institute of Technology(Kitakyushu).November 7-9 (2013)
  6. Morita H., Hanagata N. Calcium Mitigates the Toxicity of Zinc Oxide Nanoparticles to Human Lung Epithelial Cells. 7th International Symposium on Nanomedicine (ISNM2013). Nakamura Centenary Hall of Kyushu Institute of Technology(Kitakyushu).November 7-9 (2013)
  7. Hanagata N.Action of Immunostimulatory DNA Drug Can Be Changed by Nanoparticle. 7th International Symposium on Nanomedicine (ISNM2013). Nakamura Centenary Hall of Kyushu Institute of Technology(Kitakyushu).November 7-9 (2013)
【Domestic Conferences】
  1. Chen S., Hanagata N. Synthesis of silica nanotubes as multifunctional materials for biomedical applications. 日本セラミックス協会2013年年会、東京工業大学、 3月17－19日 (2013)
  2. Yamazaki. T., Sasaki M., Taguchi T. Identification of nickel-free high-nitrogen stainless steel-binding peptides/ニッケルフリー高窒素ステンレス鋼結合ペプチドの同定. 日本接着学会年次大会、明治大学駿河台キャンパス、6月20日－6月21日 （2013)
  3. Yamazaki. T,Hanagata N.　Development of immunostimulatory phosphodiester backbone-based CpG oligodeoxynucleotides/天然型免疫活性化CpGオリゴデオキシヌクレオチドの開発、第7回バイオ関連化学シンポジウム、名古屋大学東山キャンパス、9月27日－29日 （2013）
  4. Kaizuka.Y. Reconstitution and imaging of signaling molecule clusters/シグナル分子クラスターの再構成とイメージング. 第51回日本生物物理学会年会、国立京都国際会館、10月28－30日 （2013）
  5. Yamazaki. T, Mikami A., Fujimoto K., Sasaki M., Karube I., Taguchi T. Cellular regulation on peptide aptamer modified metal surface/ペプチドアプタマーを用いた金属材料表面での細胞制御、第35回日本バイオマテリアル学会大会、タワーホール船堀、11月25日－26日 （2013）
  6. Kaizuka.Y. Mobility and phosphorylation reaction network on lipid bilayers/脂質膜上の分子流動性とリン酸化分子反応ネットワーク. 第3回ソフトマター研究会、首都大学東京、12月13日－15日 （2013）
  7. 坂井勇亮, 柿木佐知朗, 竹村太郎, 花方信孝, 藤里俊哉,石原一彦, 山岡哲二. 遺伝子マイクロアレイを用いたポリエチレン多孔質体に対するin vivoでの免疫 系細胞の応答解析. 第59回高分子研究発表会7月12日　兵庫県民会館 (2013)
  8. .竹田 哲也, 池野 聡一, 市川 大輝, 中野 なおこ, 箕輪 貴司, 花方 信孝, 伊 東 史子, 伊東 進. PDZK1IP1によるTGF-βファミリーシグナル伝達経路抑制機構. 第86回日本生化学会大会　9月13日　パシフィコ横浜 (2013)
　

2012

【Original Papers】
  1. Hagiwara Y., Ando A., Onodera Y., Takemura T., Minowa T., Hanagata N., Tsuchiya M., Chimoto E., Suda H., Takahashi N., Sugaya H., Saijo Y., Itii E. Coexistence of fibrogenic and chondrogenic process in the capsule of idiopathic frozen shoulder. Osteoarthritis and Cartilage 20: 241-249 (2012)
  2. Yosie, S., Ikehata, M., Hirota, N., Takemura, T., Minowa, T., Hanagata, N., Hayakawa, T. Evaluation of mutagenicity and co-mutagenicity of strong static magnetic field up to 13T in Escherichia coli deficient in superoxide dismutase. Journal of Magnetic Resonance
    Imaging     35: 731-736 (2012)
  3. Terada, D., Kobayashi, H., Zhang, K., Tiwari, A., Yoshikawa, C., Hanagata, N. Transient charge-masking effect of applied voltage on electrospining of pure chitosan nanofibers from aqueous solution.Science and Technology of Advanced Materials 13: 015003 (9pp.) (2012)
  4. Tagaya, M., Ikoma, T., Hanagata, N., Tanaka, J. Analytical investigation of protein mediation between biomaterials and cells. Materials Express 2: 1-22 (2012)
  5. Hanagata, N. Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system. International Journal of Nanomedicine 7: 2181-2195 (2012)
  6. Zhang L., Kaizuka Y., Hanagata N. Imagaing of Fas-FasL membrane microdomains during apoptosis in a reconstituted cell-cell junction. Biochemical and Biophysical Research Communications 422: 298-304 (2012)
  7. Xu M., Li J., Fujita D., Su H., Chen H., Hanagata N. Formation of nano-bio-complex as nanomaterials dispersed in a biological solution for understanding nanobiological interaction. Scientific Reports 2: 406 (2012d)
  8. Xu L., Li X., Takemura T., Hanagata N., Wu G., Chou LL. Genotoxicity and molecular response of silver nanopaticle (NP)-based hydrogel. Journal of Nanobiotechnology 10: 16 (2012)
  9. Manoharan Y., Ji Q., Yamazaki T., Shanmugavel C., Chen S., Ganesan S., Hill JP., Ariga K., Hanagata N. Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucletotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α International Journal of Nanomedicine 7: 3625-3635 (2012)
  10. Takadate T., Onogawa T., Fujii K., Motoi F., Mikami S., Fukuda T., Kihara M., Suzuki T., Takemura T., Minowa T., Hanagata N., Kinoshita K., Morikawa T., Shirasaki K., Rikiyama T., Katayose Y., Egawa S., Nishimura T., Unno M. Nm23/Nucleotide diphosphaate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic
    analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue. Clinical Proteomics 9: 8 (2012)
  11. Ji Q., Yamazaki T., Hanagata N., Lee MV., Hill JP., Ariga K. Silica-based gene reverse transfection: Upright nanosheet network for promoted DNA delivery to cell. Chemical Communications 48: 8496-8498 (2012)
  12. Chinnathambi S., Chen S., Ganesan S., Hanagata N. Binding mode of CpG oligodeoxynucleotides to nanoparticles regulates bifurcated cytokine induction via Toll-like receptor 9. Scientific Reports 2: 534 (2012)
  13. Zhang H., Yamazaki T., Zhi C., Hanagata N. Identification of a boron nitride nanosphere-binding peptide for the intracellular delivery of CpG oligodeoxynucleotides. Nanoscale 4: 6343-6350 (2012)
  14. Chen S., Chinnathambi S., Shi X., Osaka A., Zhu Y. Hanagata N. Fabrication of nove lcollagen-silica hybrid membranes with tailored biodeg radation and strong cel lcontact guidance ability. JournalofMaterialsChemistry 22: 21885 (2012)
  15. SHIROSAKI Y., YOSHIHARA H., Chen S., BLEVINS M., NAKAMURA Y., Hanagata N.,
    HAYAKAWA S., STAMBOULIS A., OSAKA A. Electrospun poly(vinyl alcohol) as a template of silica hollow and solid micro-fibrous mats. Journal of the Ceramic Society of Japan 120: 520-524 (2012)
  16. Tagaya, M., Hanagata, N., Kobayashi, T.Templating Effect of Mesostructured Surfactant−Silica Monolithic Films on the Surface Structural and Mechanical Properties. ACS Applied Materials & Interfaces : 6169−6175 (2012)
  17. Zhuang F., Hanagata N. Synergic Toxicity of Solid Particles and Released Zinc from Zinc Oxide Nanoparticles to Human Lung Epithelial Cells. Nano Biomedicine: 4 (2): 90-112 (2012)
【Invited Review Papers】
  1. Hanagata N.「T L R 9を介したC p G誘導サイトカインのナノ粒子によるスイッチング/Switch of TLR9 mediated CpG-inducing cytokinesby nanoparticles」.アレルギーの臨床 32： 83-87 （2012）
【Books】
  1. 花方信孝「先端バイオマテリアルハンドブック」（第4章、1節　DNAマイクロ アレイ）秋吉一成ら監修　NTS (2012)
【International Conferences】
  1. Chen S., Hanagata N. Micropattering of chitosa-silicate hybrids for biomedical applications. The 9th World Biomaterials Congress (WBC),Sichuan University,Sichuan China.June 1-5 (2012)
  2. Yamazaki, T.,Zhang, H., Ikoma, T., Hanagata, N. Screening and characterization of Hydroxyapatite-Specific Bindng Peptides.The 9th World Biomaterials ongress(WBC), Sichuan University,Sichuan China. June 1-5 (2012)
  3. Yamazaki, T.,Meng W., Hanagata, N. New Nuclease-Resistant Immunostimulatory Phosphodiester-based Oligonucleotides for Immune Therapies.The 9th World Biomaterials Congress (WBC), Sichuan University,Sichuan China. June 1-5 (2012)
  4. Zhang, L., Kaizuka Y., Hanagata, N. Imaging Fas/Fasl Clusters at the Cell-membrane Interface.The 9th World Biomaterials Congress (WBC), Sichuan University,Sichuan China. June 1-5 (2012)
  5. Yamazaki, T. Application of protein engineering to biosensors.Indonesian protein societ y(IPS) seminar and congress 2012, Jember University, Jember, Indonesia. July 6-8 (2012)
  6. Yamazaki, T. Intracellular Sensing and Gene Regulation using Engineered Transcriptional Regulators. The Sweden-Japan Seminar on Nanoscience and Nanotechnology, Linkoping University, Linkoping, Sweden. September 10-11 (2012)
  7. Shanmugavel, C., Ganesan S., Hanagata, N. Preparation and characterization of silicon quantum dots for delivery of nucleic acid drugs. 4th International Conference on Advanced Nanomaterials (ANM2012), Indian Institute of Technology Madras (IIT Madras), Chennai, India. October 17-19 (2012)
  8. Tagaya, M., Hanagata, N.,Ikoma, T., Kobayashi, T., Shiba, K., Yoshioka, T. Tnaka, J. Cytotoxicity and Cancer Detection Ability of the Luminescent Nanoporous Silica Spheres Immobilized with Folic Acid Derivative. Bioceramics24, Kyushu University, Fukuoka, Japan. October 21-24 (2012)
  9. Hanagata, N. Regulation of Toll-like Receptor 9 mediated Cytokine Profile by Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles. 1st International Conference on Emerging Advanced Nanomaterials (ICEAN 2012). Mercure Hotel, Brisbane, Australia. October 22-25 (2012)
  10. Chen S., Hanagata N. Directing osteoblast alignment and elongation on the micro-grooved silica-based hybrid membrane. 2012 Internatinoal Conference on Biomaterial and Bioengineering (ICBB 2012). Regal Riverside Hotel, Hong Kong. December 19-20 (2012)
【Domestic Conferences】
  1. Shanmugavel, C., Hanagata, N. Synthesis and characterization of positively charged silicon quantum dots for delivery of nucleic acid drugs. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所　7月9、10日 (2012)
  2. Shanmugavel, C., Hanagata, N. Effect of interaction mode of CpG oligodeoxynucleotides with TLR9 on bifurcated cytokine induction. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所　7月9、10日 (2012)
  3. Zhang, H., Yamazaki, T., i Zhi, C., Hanagata, N. Identification of a specific binding peptide to boron nitride nanospheres for delivery of CpG oligodeoxynucleotides. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所　7月9、10日 (2012)
  4. Chen S., Hanagata N. Synthesis of silica nanotubes for bone generation. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所　7月9、10日 (2012)
  5. Zhuang, F.,Hanagata, N. Response of human lung epithelial cells to the toxicity of zinc oxide nanoparticles. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所　7月9、10日 (2012)
  6. Chechetka, S., Yamazaki, T., Hanagata, N. Characterization of interleukin-6 induction by natural CpG oligodeoxynuxleotide. 第6回 ナノバイオメディカル学会大会　独立行政法人産業技術総合研究所 　7月9、10日 (2012)
  7. Yamazaki, T., Sasaki M., Tguchi T. Screening of nickel-free high-nitrogen stainless steel-binding peptides. 日本バイオマテリアル学会シンポジウム2012大会　仙台国際センター 11月26、27日 (2012)
  8. Yamazaki, T., Sode K.An Amperometric Sensor based on a Soluble Molecularly Imprinted Catalyst for Fructosyl Valine. 第22回日本メイラード学会　東京農工大学 12月21、22日 (2012)

 

2011

【Original Papers】
  1. Grandcolas, M., Ye, J., Hanagata, N. Combination of photocatalytic and antibacterial effects of silver oxide loaded titania nanotubes. Materials Letters 65 (2): 236-239 (2011)
  2. Hanagata, N., Li, X., Morita, H., Takemura, T., Li, J., Minowa, T. Characterization of osteoblast-specific transmembrane protein IFITM5 and analysis of Ifitm5 deficient mice. Journal of Bone and Mineral Metabolism 29: 279-290 (2011)
  3. Chen, S., Hirota, N., Okuda, M., Takeguchi, M., Kobayashi, H., Hanagata, N., Ikoma, T. Microstructures and rheological properties of tilapia fish scale collagen hydrogels with aligned fibrils fabricated under magnetic fields. ACTA Biomaterialia 7: 644-652 (2011)
  4. Zhu, Y., Meng, W., Li, X., Gao, H., Hanagata,N. Design of mesoporous silica/CpG oligonucleaotides complexes for enhancement of delivery efficiency. The Journal of Physical Chemistry 115: 447-452 (2011)
  5. Chen, S., Osaka, A., Hanagata, N. Collagen-templated sol-gel fabrication, microstructure, in vitro apatite deposition, and osteoblastic cell MC3T3-E1 compatibility of novel silica nanotube compacts. Journal of Materials Chemistry  21 (12): 4332-4338 (2011)
  6. Xu, M., Fujita, D., Sagisaka K., Watanabe, E., Hanagata, N. Novel method for production of extended single-layer graphene.ACS Nano 5 (2): 1522-1528 (2011)
  7. Zhi, C., Meng, W., Yamazaki, T., Bando, Y., Golberg, D., Tang, C., Hanagata, N. BN nanospheres as CpG ODN carrier for activation of toll-like receptor 9. Journal of Materials Chemistry 21: 5219-5222 (2011)
  8. Xu, L., Takemura, T., Xu, M., Hanagata, N. Toxicity of silver nanoparticles as assessed by global gene expression analysis. Materials Express1: 74-79 (2011)
  9. Migita, S., Hanagata, N., Tsuya, D., Yamazaki, T., Sugimoto, Y., Ikoma, T., Transfection efficiency for size-separated cells synchronized in cell cycle by microfluidic device. Biomedical Microdevices 13: 725-729 (2011)
  10. Xu, M., Fujita, D., Chen, H., Hanagata, N. Formation of monolayer and few-layer hexagonal boron nitride nanosheets via surface segregation. Nanoscale 3: 2854-2858 (2011)
  11. Hanagata, N., Li, X. Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes. Biochemical and Biophysical Research Communications 409: 378-384 (2011)
  12. Tagaya, M., Ikoma, T., Takemura, T., Hanagata, N., Okuda, M., Yoshioka, T., Tanaka, J. Detection of interfacial phenomena with osteoblast-like cell adhesion on hydroxyapatite and oxidized pol y(styrene) by quatrz crystal microbalance with dissipation.Langmur 27：7635-7644 (2011)
  13. Chen, S., Osaka, A., Ikoma, T., Morita, H., Li, J., Ogawa, N., Takeguchi, M., Hanagata, N. Fabrication, microstructure, and BMP-2 delivery of novel biodegradable and biocompatible silicate-collagen hybrid fibril sheets.Journal of Materials Chemistry 21: 10942-10948 (2011)
  14. Zhu, Y., Li, X., Yang, J., Wang, S., Gao, H., Hanagata, N. Cpmposition-structure-property relationship of CaO-MxOy-SiO2-P2O5 (M=Zr, Mg, Sr) mesoporous bioactive glass (MBG) scaffolds. Journal of Materials Chemistry 21: 9208-9218 (2011)
  15. Tagaya, M., Ikoma, T., Takemura, T., Hanagata, N., Yoshioka, T., Tanaka, J. Effect of interfacial proteins on osteoblast-like cell adhesion to hydroxyapatite nanocrystals. Langmuir 27: 7645-7653 (2011)
  16. Zhi, C., Hanagata, N., Bando, Y., Golberg D. Dispersible shortened boron nitride nanotubes with improved molecular-loading capacity. Chemistry an Asian Journal 6: 2530-2535 (2011)
  17. Zhu, Y., Meng, W., Gao, H., Hanagata, N. Hollow mesoporous silica/poly (L-lysine) particles for codelivery of drug and gene with enzyme-triggered release property. The Journal of Physical Chemistry C 115: 13630-13636 (2011)
  18. Zhu, Y., Meng, W., Hanagata, N. Cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN)-capped hollow mesoporous silica particles for enzyme-triggered drug delivery. Dalton Transaction 40: 10203-10208 (2011)
  19. Meng, W., Yamazaki, T., Nishida, Y., Hanagata, N. Nuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonists. BMC Biotechnology 11: 88 (2011)
  20. Chen, S., Shi, X., Morita, H., Li, J., Ogawa, N., Ikoma, T., Hayakawa, S., Shirasaki, Y., Osaka, A., Hanagata, N. BMP-2 loaded silica nanotube fibrous meshes for bone generation. Science and Technology of Advanced Materials 12: 065003-065008 (2011)
  21. Tagaya M., Yamazaki, T., Tsuya, D., Sugimoto, Y., Hanagata, N., Ikoma, T. Nano-/micro-structural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion. Macromolecular Bioscience 11: 1586-1593 (2011)
  22. Tagaya, M., Ikoma, T., Takemura, T., Hanagata, N., Yoshioka, T., Tanaka, J. Protein adsorption and subsequent fibroblasts adhesion on hydroxyapatite nanocrystals. IOP Conf. Series: Materials Science and Engineering 18: 192009-192013 (2011)
  23. Tagaya, M., Ikoma, T.; Hanagata, N., Tanaka, J. Competitive adsorption of fibronectin and albumin on hydroxyapatite nanocrystals. Science and Technology of Advanced Materials 12: 034411-034417 (2011)
  24. Tagaya, M., Ikoma, T., Takeguchi, M., Hanagata, N., Tanaka, J. Interfacial serum protein effect on biological apatite growth. Journal of Physical Chemistry C 115 (45): 22523-22533 (2011)
  25. Tagaya, M., Yamazaki, T., Migita, S., Hanagata, N., Ikoma, T. Hepatocyte adhesion behavior on modified hydroxyapatite nanocrystals with quartz crystal microbalance. Bioceramics Development and Applications 1: 110157-110161 (2011)
  26. Tagaya, M., Ikoma, T., Takemura, T., Migita, S., Okuda, M., Yoshioka, T., Hanagata, N., Tanaka, J. Initial adhesion behavior of fibroblasts onto hydroxyapatite nano-crystals. Bioceramics Development and Applications 1: 110165-110169 (2011)
  27. Okuda M., Ogawa N., Takeguchi M., Hashimoto A., Chen S., Hanagata N., Ikoma T. Minerals and aligned collagen fibrils in tilapia fish scales: Structural analysis using dark-field and energy-filtered transmission electron microscopy and electron tomography. Microscopy and Microanalysis 17: 788-798 (2011)
  28. Hanagata N., Zhuang F., Connolly S., Li J., Xu M. Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome analysis. ACS Nano 5: 9326-9338 (2011)

【International Conferences】
  1. Chen, S., Ikoma, T., Li, J., Morita, H., Osaka, A., Takeguchi, M., Hanagata, N. Collagen-templated sol-gel preparation of ultra-fine silica nanotube films and osteoblastic cell proliferation. 35th International Conference and Exposition on Advanced Ceramics and Composites (ICACC), Daytona Beach FL, USA. Jan 23-28 (2011)
  2. Esumi, M., Yamaguchi, H., Kuroda, K., Munekata, Y., Obana, Y., Takahashi, R., Fuchinoue, F., Sugitani, M., Nagase, H., Takemura, T., Minowa, T., Hanagata, N., Nakayama, H., Takayama, T. Liver microenvironment containing cytokeratin 19-positive cells associated with the early recurrence of hepatocellular carcinoma. 3rd JCA-AACR Special Joint Conference, Tokyo Bay Hotel Tokyu, March 1-3 (2011)
  3. Zhu, Y., Hanagata, N. Folate-conjugated Fe3O4@SiO2 hollow mesopheres as potential carrier for targeted drug delivery. 2nd International Conference on Multifunctional, Hybrid and Nanomaterials. The Palais des Congregraves, Strasbourg, France, March 6-10 (2011)
  4. Zhu, Y., Hanagata, N. Design of mesoporous silica/CpG ODN complexes to enhance delivery efficiency. International Conference on Materials for Advanced technologies. Suntec Singapore Hotel, Singapore, Jun 26-July 1 (2011)
  5. Yamazaki, T. Hanagata, N. Enhancement of the theraqeutic efficiency of a human toll-lilke receptor 9 agonist via bio-and nano-technology. International Workshop on Biomedical Sciences and Technologies, Anna University, Chennai, India, March 2-4 (2011)
  6. Yamazaki, Y., Meng, W., Zhi, C., Zhu, Y., Hanagata, N. Novel CpG oligodeoxynucleotide and its delivery system. 9th annual Bio Nanotech Conference, Boston, US., 13-16 June (2011)
  7.  Ogawa, N., Okuda, M., Hanagata, N., Takeguchi, M. The structural features of the mineral particles on the surface of the aligned type I collagen fibrils in the fish scale. Gordon Research Conference on Collagen. Colby-Sawyer College,New London, USA. July 7-22 (2011)
  8. Osaka, A., Chen, S., Hanagata, N., Shirosaki, Y., Hayakawa, S. Sol-Gel preparation of silica-based nano-particles and fibers for biomedical applications. the 3rd IC4N 2011, Creta Maris Hotel Conference Center ,Hersonissos, Crete,Greece, June 26-29 (2011)
  9. Chinnathambi S., Krishnan, V., Ariga, K., Hanagata, N. Water soluble silicon quantum dots as fluorescent probes for bio-applications. The Symposium on Micro/Nano Aspects of Biomaterials , Kyoto, Japan, July 19 (2011)
  10. Suwarti, Yamazaki, T., Hanagata, N. C-terminal ligand binding analysis of human Toll-like receptor 9. The Symposium on Micro/Nano Aspects of Biomaterials , Kyoto, Japan, July 19 (2011)
  11. Zhang, L., Kaizuka, Y., Hanagata, N. Imaging Study of Proteins Interaction Following the Contact of Living Cell to Artificial Membrane. The Symposium on Micro/Nano Aspects of Biomaterials , Kyoto, Japan, July 19 (2011)
  12. Zhang, H., Yamazaki, T., Zhi, C., Hanagata, N. Identification of Boron Nitride Nanospheres Binding Peptides. The Symposium on Micro/Nano Aspects of Biomaterials , Kyoto, Japan, July 19 (2011)
  13. Meng, W., Yamazaki, T., Hanagata, N. Novel Phosphodiester CpG Oligodeoxynucleotides with High Stimulatory Effects on Human Toll-like Receptor 9. The Symposium on Micro/Nano Aspects of Biomaterials , Kyoto, Japan, July 19 (2011)
  14. Yamazaki, T., Hanagata, N. Identification of Hydroxyapatite-Binding Peptides. STAC5-AMDI2, Yokohama, Japan. June 22-24 (2011)
  15. Ogawa, N., Okuda, M., Hanagata, N., Takeguchi, M. The structural features of the mineral particles on the surface of the aligned type I collagen fibrils in the fish scale. Gordon Research Conference on Collagen. Colby-Sawyer College,New London,USA, July 17-22 (2011)
  16. Suwarti, Yamazaki, T., Hanagata, N. Analysis of CpG ODNS binding of human toll like receptor 9. Infection and Immunity (Cold Spring Harbor Asia), Suzhou Dushu Lake Conference Center, Shuzou, China, Sep. 8-12 (2011)
  17. Yamazaki, T., Meng, W., Hanagata, N. Novel CpG phosphodiester oligodeoxynucleotides as human toll-like receptor 9 agonists. Infection and Immunity (Cold Spring Harbor Asia), Suzhou Dushu Lake Conference Center, Shuzou, China, Sep. 8-12 (2011)
【Domestic Conferences】
  1. Meng, W., Yamazaki, T., Hanagata, N. Construction of nuclear-resistant phosphodiester CpG oligonucleotides for pollinosis therapy. ナノ・バイオメディカル学会　名古屋大学野依記念学術交流会館　2月21、22日　(2011)
  2. Zhang, L., Kaizuka, Y., Hanagata, N. Molecular organization at the live cell-biomembrane interface. ナノ・バイオメディカル学会　名古屋大学野依記念学術交流会館　2月21、22 (2011)
  3. Zhu, Y., Hanagata, N. Fe3O4@Sio2 hollow mesoporous spheres as potential carrier for anticancer drug delivery. ナノ・バイオメディカル学会　　名古屋大学野依記念学術交流会館 2月21、22日　(2011)
  4. Zhi, C., Meng, W., Yamazaki, T., Bando, Y., Golberg, D., Tang, C., Hanagata, N. BN nanospheres as CpG ODN carrier for activation of toll-like receptor 9. ナノ・バイオメディカル学会　名古屋大学野依記念学術交流会館　2月21、22日 (2011)
【Books】
  1. 花方信孝、「機械工学ハンドブック」中島尚正ら編（分担執筆）、朝倉書店 (2011)

2010

【Original Papers】
  1. Hanagata, N., Takemura, T., Minowa, T. Global gene expression analysis for evaluation and design of biomaterials. Science and Technology of Advanced Materials 11: 01300 (12pp) (2010)
  2. Zhu, Y., Ikoma, T., Hanagata, N., Kaskel, S. Rattle-type Fe3O4@SiO2 hollow mesoporous spheres as carriers for drug delivery. Small 6 (3): 471-478 (2010)
  3. Okuda, M., Takeguchi, M., Ruairc, Ó, Tagaya, M., Zhu, Y., Hashimoto, A., Hanagata, N., Schmitt, W. and Ikoma, T. Structure analysis of hydroxyapatite coating on magnetic nanoparticles using energy filter imaging and electron tomography. Journal of Electron Microscopy 159 (2): 173-174 (2010)
  4. Tonegawa, T., Ikoma, I., Hanagata, N., Tanaka, J. Crystal structure refinements of A-type carbonate apatite with X-ray powder diffraction. Journal of Materials Science 45 (9): 2419-2426 (2010)
  5. Tagaya, M., Ikoma, T., Migita, S., Okuda, M., Takemura, T., Hanagata, N., Yoshioka, T., Tanaka, J. Fetal bovin serum adsorption onto hydroxyapatite sensor monitoring by quartz crystal microbalance with dissipation technique. Materials Science and Engineering B 173: 176-181 (2010)
  6. Tonegawa T., Ikoma T., Suetsugu Y, Igawa N, Matsushita Y., Yoshioka T., Hanagata N., Tanaka J. Thermal expansion of type A carbonate apatite. Materials Science and Engineering B 173: 171-175 (2010)
  7. Tagaya, M., Ikoma, T., Hanagata,N., Chakarov, D., Kasemo, B., Tanaka, J. Reusable hydroxyapatite nanocrystal sensors for protein adsorption. Science and Technology of Advanced Materials 11: 045002 (8pp) (2010)
  8. Xu, M., Fujita, D., Gao, J., Hanagata, N. Auger electron spectroscopy: a rational method for determining thickness of graphene films. ACS Nano 4 (5): 2937-2945 (2010)
  9. Okuda, M., Takeguchi, M., Zhu, Y., Hashimoto, A., Ogawa, N., Tagaya, M., Chen, S., Hanagata, N., Ikoma, T.  Structural analysis of rattle-type hollow mesoporous silica spheres using electron tomography and energy filtered imaging. Surface and Interface Analysis 42 (10-11): 1548-1551 (2010)
  10. Migita, S., Funakoshi, K., Tsuya, D., Yamazaki, T., Taniguchi A., Sugimoto, Y., Hanagata, N., Ikoma, T.  Cell cycle and size sorting of mammalian cells using microfluidic device. Analytical Methods 2: 657-660 (2010)
  11. Chen, S., Ikoma, T., Ogawa, N., Migita, S., Kobayashi, H., Hanagata, N. In vitro formation and thermal transition of novel hybrid fibrils from type I fish collagen and type I porcine collagen. Science and Technology of Advanced Materials 11: 035001 (4pp) (2010)
  12. Xu, M., Fujita, D., Hanagata, N. Monitoring electron-beam irradiation effect on graphenes by temporal Auger electron spectroscopy. Nanotechnology 21: 265705(7pp) (2010)
  13. Xu, M., Fujita, D., Kajiwara, S., Minowa, T., Li, X., Hanagata, N. Electronic property of nano-oxides linking to cytotoxity. Biomaterials 31: 8022-8031 (2010)
  14. Hanagata, N., Xu, M., Takemura, T., Zhuang, F. Cellular response to ZnO nanoparticle toxicity inferred from global gene expression profiles. Nano Biomedicine 2: 153-169 (2010)
【Proceeding】
  1. Chen, S., Ikoma, T., Takeguchi M., Hanagata, N. In vitro bioactivity of Ca-containing silica hollow fiber scafforlds. Archives of BioCeramics Research 10: 130-132 (2010)
【Invited Review Papers】
  1. Hanagata, N./花方信孝　「バイオセラミックスのマテリアルゲノミクス解析」バイオマテリアルVol.28 (2): 116-123 (2010)
【Books】
  1. Xu, M., Chen, H., Shi, M., Fujita, D., Hanagata, N. “Biomedicine Applications of Nanomaterials” in Handbook of Innovative Nanomaterials: From Synthesis and Applications, Fang, X. and Wu, L. ed., Pan Stanford Publishing Pte Ltd. (2010)
【Invited Lectures】
  1. Hanagata, N. Global gene expression analysis to approach mechanism of CuO nanoparticle toxicity. China Biomedical Engineering Conference. Beijing, December 2-4 (2010)
  2. Hanagata, N. Interdisciplinary studies between biology and nanotechnology, Zhejiang University, China, June 3 (2010)
  3. Hanagata, N/花方信孝：「遺伝子発現解析のバイオマテリアルへの応用」　次世代バイオマテリアルを考える会　明治大学理工学部　3月10日　(2010)
  4. Hanagata, N./花方信孝：「DNA Microarrayを用いた材料の表面化学的・物理的特性に対する細胞応答反応の解明」 日本金属学会2010年春期（第146回）大会　筑波大学　つくば市　3月28日－30日　(2010)
【International Conferences】
  1. Tagaya M., Ikoma, T., Hanagata, N., Yoshioka, T., Tanaka, J. Competitive adsorption of fibronectin and albumin on hydroxyapatite nanocrystals analyzed in situ by a quartz crystal microbalance with dissipation technique. 239th American Chemical Society National Meeting & Exposition. Moscone Center, San Francisco, USA. March 20-25 (2010)
  2. Xu, M., Fujita, D., Hanagata, N. The Effect of Physiochemical Properties of Nano-Oxides on Cytotoxicity, MANA International Symposium 2010, Epochal Tsukuba International Congress Center, Tsukuba, Japan., March 3-5 (2010)
  3. Xu, M., Fujita, D., Hanagata, N. The Effect of physicochemical properties of nano-oxides on cytotoxicity. First World Conference On Nanomedicine And Drug Delivery, Windsor Castle, Kottayam, Kerala ,India. April 16-18 (2010)
  4. Xu, X., Fujita, D., Gao, J., Hanagata, N. Scanning Auger electron spectroscopy: a rational method for characterization of graphene layers. Recent Advances in Graphene and Related Materials, Singapore, Aug. 1-6 (2010)
  5. Xu, M., Fujita, D., Hanagata, N. Electron-beam irradiation effect on graphene layers. International Vacuum Congress, Bejing, China, Aug. 23-27 (2010)
  6. Xu, M., Fijita, D., Hanagata, N. Scanning Auger Electron Spectroscopy: a New and Universal Technique for Identifying Graphene. Internation Conference on Modern Materials & Technilogies, Palazzo dei Congressi,Montecatini Terme Italy, June 6-11 (2010)
  7. Takadate, T., Onogawa, T., Motoi, F., Fujii, K., Maeda, S., Takemura, T., Mikami, S., Yamada, S., Fukuda, T., Minowa, T., Hanagata, N. et al. Discovery of Prognostic Factor using Proteomic Analysis with Formalin-Fixed Paraffin- Embedded Tissues of Pancreatic Cancer. Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society, Fukuoka, July 11-13 (2010)
  8. Chen, S., Hirota, N., Okuda, M., Takeguchi, M., Kobayashi, H., Hanagata, N., Ikoma, T. Rheological Properties of Magnetically Aligned Collagen Fibril Hydrogels. 23th European Conference of Biomaterials, Tampere, Finland, September 11-15 (2010)
  9. Xu, L., Chen, L., Li, X., Takemura, T., Hanagata, N., Wang, C., Xi, T. In vitro cytotoxicity and genotoxicity of siliver-nanoparticles-containing hydrogel in Hela cells. TERMIS-AP 2010 Annual Conference. Sheraton on the Park, Sydney, Australia, September 15-17 (2010)
  10. Zhu, Y., Hanagata, N., Kobayashi, H. Modified hollow mesopheres as carriers for targeted drug delivery. 11th IUMRS International Conference in Asia. Qingdao International Convention Center, Qingdao, China. Sept. 25-28 (2008)
  11. Zhu, Y., Hanagata, N. Hollow mesoporous silica spheres as carrier for drug delivery. 8th Annual Congress of International Drug Discovery Science.  Beijing International Convention Center, Beijin, China. Oct. 23-26 (2010)
  12. Zhu, Y., Hanagata, N. Rattle-type Fe3O4@Sio2 hollow mesoporous spheres as potential carriers for anti-cancer drug delivery. The 10th Asia Bioceramics Symposium. Yogyakarta, Indonesia, November 2-5 (2010)
  13. Chen, S., Ikoma, T., Takeguchi M., Hanagata, N. In vitro bioactivity of Ca-containing silica hollow fiber scafforlds. The 10th Asia Bioceramics Symposium. Yogyakarta, Indonesia, November 2-5 (2010)
【Domestic Conferences】
  1. 奥田充宏、竹口雅樹、小川展弘、橋本綾子、多賀谷基博、陳松、花方信孝、生駒 俊「魚鱗中のリン酸カルシウム分布」 セラミックス協会2010年年会 「セラミックスに関する顕微鏡写真展」東京農工大,東京都　3月22－24日 (2010)
  2. 有坂智帆、多賀谷基博、生駒俊之、花方信孝 「SPR法を用いた水酸アパタイトナノ結晶表面へのフィブリノーゲンの結合挙動の計測」 第48回セラミックス基礎科学討論会、 沖縄コンベンションセンター,宜野湾市沖縄　1月12、13日　(2010)
  3. Xu. M., Fujita, D., Hanagata, N. Comparative Study of Cytotoxicity Caused by ZnO Nanoparticles and Zn2+ Ions. 応用物理学会春季大会　東海大学、平塚市　3月17－20日 (2010)
  4. Xu. M., Fujita, D., Hanagata, N.　Electron-Beam Irradiation Effect on Mechanical Exfoliated Graphenes. 応用物理学会春季大会 東海大学、平塚市　3月17－20日 (2010)
  5. 高森　靖、金指　幹元、五味　一博、箕輪　貴司、勝田　奈穂子、新井　高、花方　信孝 「さい帯由来細胞をもちいた幹細胞性の維持とその増幅への応用」 第9回再生医療学会総会　広島国際会議場、広島市　3月18、19日 (2010)
  6. 小野川徹、前田晋平、高舘達之、竹村太郎、三上紗弥香、福田哲也、山田誠子、板東泰彦、碓井史彦、箕輪貴司、花方信孝、西村俊秀、森川孝則、元井冬彦、力山敏樹、片寄　友、江川新一、海野倫明 「病院保管のホルマリン固定化永久組織からプロテオーム解析はどこまでできるか？」 第22回日本肝胆膵外科学会・学術集会　東北大学、仙台　5月27日 (2010)
  7. 前田晋平、小野川徹、高舘達之、森川孝則、竹村太郎、三上紗弥香、山田誠子、福田哲也、板東泰彦、碓井史彦、箕輪貴司、花方信孝、西村俊秀、力山敏樹、片寄　友、江川新一、海野倫明 「FFPE組織を用いた網羅的プロテオーム解析による胆道癌新規バイオマーカーの探索」 第22回日本肝胆膵外科学会・学術集会　東北大学、仙台　5月27日 (2010)
  8. 高舘達之、小野川徹、前田晋平、元井冬彦、森川孝則、竹村太郎、三上紗弥香、山田誠子、福田哲也、板東泰彦、碓井史彦、箕輪貴司、花方信孝、西村俊秀、力山敏樹、片寄　友、江川新一、海野倫明 「ホルマリン固定パラフィン包埋組織を用いた臨床プロテオミクスによる膵癌新規バイオマーカーの探索」 第22回日本肝胆膵外科学会・学術集会　東北大学、仙台　5月27日(2010)
  9. Tukamoto, T., Li, X., Hanagata, N., Demura, M. Expression, purification and characterization of osteoblastspecific membrane protein Ifitm5 in detergent solubilized system. 第10回蛋白質科学会年会　札幌　6月16－18日　(2010)
  10. 大川美佳、小川展弘、Chen Song、花方信孝、多賀谷基博、生駒俊之、浦和寛、都木靖彰 「ティアピアI型コラーゲンの熱安定性と線維化能」 日本水産学会秋季大会、京都大学、京都　9月22-25日　（2010）
  11. Meng, W., Yamazaki, T., Hanagata, N. Development of novel CpG oligodeoxynucleotides for Toll-like receptor 9 activation. 第33回日本分子生物学会　神戸ポートアイランド　12月7-10日　(2010)
  12. Zhu Y., Hanagata, N. Fe3O4@SiO2 Hollow mesoporous spheres as carriers for drug delivery. 第32回日本バイオマテリアル学会　グランドプリンスホテル広島　11月29-30日　(2010)
  13. 江橋具、柿木佐知朗、竹村太郎、箕輪貴司、花方信孝、小林尚俊、由井伸彦、山岡哲二 「皮下に埋入したバイオマテリアル界面に対する生体応答の遺伝子網羅解析」 第32回日本バイオマテリアル学会　グランドプリンスホテル広島　11月29-30日　(2010)
  14. Chen, S., Ikoma, T., Osaka, A., Hanagata, N. Development of novel silica nanotube scaffolds using collagen fibril hydrogels as novel templates. 第32回日本バイオマテリアル学会　グランドプリンスホテル広島　11月29-30日　(2010)
  15. Xu. M., Fujita, D., Hanagata, N.　What causes toxic effect of nanomaterials – size, cation, or electron/hole? MRS-Jシンポジウム　横浜　12月20-23日　(2010)

2009

【Publications】
  1. Zhang, L., Hanagata, N., Maeda, M., Minowa, T., Ikoma, T., Fan, H., and Zhang, X. Porous hydroxyapaptite and biphasic calcium phosphate ceramics promote ectopic osteoblast differentiation from mesenchymal stem cells. Science and Technology of Advanced Materials 10 (2) : 025003-1-9 (2009)
  2. Zhu, Y., Stefan, K., Ikoma, T. and Hanagata, N. Magnetic SBA-15/poly(N-isopropylacrylamide) composite: Preparation, characterization and temperature-responsive drug release property. Microporous and Mesoporous Materials 123 (1-3): 107-112 (2009)
  3. Zhu, Y., Emanuel, K., Ikomoa, T., Hanagata, N. and Stefan, K. An Efficient Route to Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres Using Colloidal Carbon Spheres Templates. Chemistry of Materials 21 (12) :2547-2553 (2009)
  4. Zhu, Y., Emanuel, K., Stefan, K., Ikoma, T. and Hanagata, N. Nanocasting Route to Ordered Mesoporous Carbon with FePt Nanoparticles and Its Phenol Adsorption Property. Journal of Physical Chemistry C 113 (15): 5998-6002 (2009)
  5. Yamayoshi, S., Yamashita ,Y., Li, J., Hanagata, N., Minowa, T., Takemura, T. and Koike, S.  Scavenger receptor B2 is a cellular receptor for Enterovirus 71. Nature Medicine 15 (7): 798-801 (2009)
  6. Okuda, M., Takeguchi, M., Tagaya, M., Tonegawa, T., Hashimoto, A., Hanagata, N. and Ikoma, T. Elemental distribution analysis of type I collagen fibrils in tilapia fish scale with energy-filtered transmission electron microscope. Micron 40 (5-6) : 665-66 8 (2009)
  7. Ikoma, T., Tagaya, M., Hanagata, N., Yoshioka, T., Chakarov, D., Kasemo, B. and Tanaka J.  Protein Adsorption on Hydroxyapatite Nanosensors with Different Crystal Sizes Studied In Situ by a Quartz Crystal Microbalance with the Dissipation Method. Journal of the American Ceramic Society 92 (5): 1125-1128 (2009)
  8. Xu, M., Fujita, D. and Hanagata, N. Perspectives and Challenges of Emerging Single-Molecule DNA Sequencing Technologies. Small 5 (23): 2638-2649 (2009)
  9. Tagaya, M., Ikoma, T., Takemura, T., Okuda, M., Hanagata, N., Yoshioka, T., Chakarov, D., Kasemo, B. and Tanaka, J. Adsorption of proteins derived from fetal bovine serum onto hydroxyapatite nanocrystals with quartz crystal microbalance technique. Key Engineering Materials 396-398: 47-50 (2009)
  10. Ikoma, T., Tagaya, M., Tonegawa, T., Okuda, M., Hanagata, N., Yoshioka, T., Chakarov, D., Kasemo, B. and Tanaka, J.  The surface property of hydroxyapatite: Sensing with quartz cryatal microbalance. Key Engineering Materials 396-398: 89-92 (2009)
  11. Tonegawa, T., Ikoma, I., Yoshioka, T., Shinozaki, K., Hanagata, N. and Tanaka, J.  Adsorption and sustained release of insulin from zinc hydroxyapatite microparticle with poly (lactic acid) coating. Key Engineering Materials 396-398: 507-510 (2009)
  12. Tonegawa T., Ikoma T., Suetsugu Y, Igawa N, Matsushita Y., Yoshioka T., Hanagata N., Tanaka J. Crystal structure of high-purity type A carbonate apatite. Bioceramics 22: 93-96 (2009)
  13. Li Y., Hirota N., Okuda M., Chen S., Tagaya T., Shirosaki Y., Hayakawa K., Osaka A., Hanagata N., Ikoma T.  Viscoelastic property of collagen gels with aligned fibril structure.Bioceramics 22: 661-664 (2009)
  14. Tagaya, M., Ikoma, T., Takemura, T., Okuda, M., Yoshioka, T., Hanagata, N., Tanaka, J.  Initial adhesion behavior of fibroblasts onto hydroxyapatite nano-crystals.Bioceramics 22: 439-442 (2009)
  15. Tagaya, M., Yamazaki, T., Takemura, T., Hanagata, N., Ikoma, T.  Hepatocyte adhesion behavior on modified hydroxyapatite nanocrystals with quartz crystal microbalance. Bioceramics 22: 407-410 (2009)
【Invited Lectures】
  1. Hanagata, N.　Gene expression profile of osteoblast-like cells on calcium phosphate biomaterials. International Conference on Quality Control of Biomaterials and Bioproducts.Beijin, China. September 28-29 (2009)
  2. Hanagata, N./花方信孝 「ナノテクノロジー・ネットワークにおける取り組みと産学官研究者支援によるイノベーション創出」 第2回東北大学医学系NM-GCOE拠点シンポジウム 　東北大学医学部,　仙台.　7月11日　(2009)
  3. Hanagata, N.　Gene expression profile of osteoblasts cultured on various surface structures. UW CNT Conference on Nanotechnology & UW/NIMS MOLAT Forum. University of Washington, Seattle, USA. June 10-12 (2009)
【International Conferences】
  1. Zhu, Y., Ikoma, T. and Hanagata, N.  Efficient Route to Rattle-type Fe3O4@SiO2 Hollow Mesoporous Spheres and Their Intracellular Localization and Cytotoxicity   International Conference on Nanoscience & Technology, China (2009)
  2. Zhu, Y., Ikoma, T. and Hanagata, N.  Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres as Carriers for Drug Delivery.  BIT's 7th Annual Congress of International Drug Discovery Scien (2009)
  3. Hanagata, N.  Gene expression profile of osteoblasts cultured on various surface structures. 2009 UW CNT Conference on Nanotechnology & UW/NIMS MOLAT Forum (2009)
  4. Ikoma,T., Tagaya, M., Yamazaki, T. and Hanagata, N. In situ analyzes of interfacial interaction between cells and biomaterials by using quartz crystal microbalance with dissipation technique. 8th International Symposium on Frontiers in Biomedical Polymers (2009)
  5. Tonegawa T., Ikoma T., Suetsugu Y, Igawa N, Matsushita Y., Yoshioka T., Hanagata N., Tanaka J. Thermal expansion of type A carbonate apatite. The Third International Conference on the Science and Technology. Yokohama, Japan. Jun 16-18 (2009)
  6. Tagaya, M., Ikoma, T., Okuda, M., Takemura, T., Yoshioka, T., Hanagata, N., Tanaka, J.Monitoring of adsorption of multiple proteins onto hydroxyapatite nanosensor by quartz crystal microbalance with dissipation technique. The Third International Conference on the Science and Technology. Yokohama, Japan. Jun 16-18 (2009)
  7. Tonegawa T., Ikoma T., Suetsugu Y, Igawa N, Matsushita Y., Yoshioka T., Hanagata N., Tanaka J. Crystal structure of high-purity type A carbonate apatite. 22nd International Symposium on Ceramics in Medicine, Daegu Korea Oct. 26-29 (2009)
  8. Li Y., Hirota N., Okuda M., Chen S., Tagaya T., Shirosaki Y., Hayakawa K., Osaka A., Hanagata N., Ikoma T. Rheological property of collagen gels with aligned fibril structure. 22nd International Symposium on Ceramics in Medicine, Daegu Korea Oct. 26-29 (2009)
  9. Tagaya, M., Ikoma, T., Takemura, T., Okuda, M., Yoshioka, T., Hanagata, N., Tanaka, J. Initial adhesion behavior of fibroblasts onto hydroxyapatite nano-crystals. 22nd International Symposium on Ceramics in Medicine, Daegu Korea 26-29 Oct. (2009)
  10. Ikoma, T., Tagaya, M., Yamazaki, T., Takemura, T., Hanagata, N. Hepatocyte adhesion behavior on modified hydroxyapatite nanocrystals with quartz crystal microbalance. 22nd International Symposium on Ceramics in Medicine, Daegu Korea Oct. 26-29 (2009)
  11. Xu, M., Fuhita, D., Gao, H., Kajiwara, S., Li, X., Minowa, T., Hanagata, N. Comparative Evaluation of Nano-Oxides Impact on Cellular Response. ChinaNANO2009 -International Conference on Nanosci. and Technol. Beijing, China September 1-3 (2009)
  12. Xu, M., Fujita, D., Gao, H., Watanabe, E., Hananagata, N. Large-scale, uniform and transferrable graphene films synthesized by chemical vapor deposition. International Microprocesses and Nanotechnology Conference, Sapporo, Japan November 16-19 (2009)
  13. Okuda, M., Takeguchi, M., Zhu, Y., Hashimoto, A., Tagaya., M., Hanagata, N., Ikoma, T. Structural Analysis of Rattle-type Hollow Mesoporous Spheres using Electron Tomography and Energy Filter Imagin. 7th International Symposium on Atomic Level Characterizations. Hawaii, USA. December 6-11 (2009)
【Domestic Conferences】
  1. Xu, M., Fujita, D. and Hanagata, N. Characterization of Nanomaterials for Risk Assessment. 平成21年度NIMSナノ計測センター研究成果発表会 - 公開セミナー (2009)
  2. Xu, M., Fujita, D. Kajiwara, S., Li, X., Minowa, T. and Hanagata, N. Nanoparticle effect on NIH3T3 cell viability. 2009年（平成21年）春季第56回応用物理学関係連合講演会 （2009）
  3. Ebashi, T., Takemura, T., Minowa, T., Hanagata, N., Kobayashi, H. and Yamaoka T. ｢スキャフォールド材料に対する生体反応の遺伝子網羅的解析｣ 第31回日本バイオマテリアル学会 （2009）
  4. Xu, M., Fujita, D. Hong, G., Kajiwara, S., Li, X., Minowa, T. and Hanagata, N. Evaluation of Cytotoxicity of Nano-Oxides. 秋季第70回応用物理学会学術講演会 (2009)
  5. Li, X., Kajiwara, S., Minowa, T. and Hanagata, N. ｢骨芽細胞特異的膜タンパク質IFITM5の機能解析：相互作用タンパク質ネットワークの解明 / Functional Analysis of Osteoblast-Specific Membrane Protein IFITM5: Elucidation of Protein Network Interacted with IFITM5｣ 第32回分子生物学会年会 (2009)
  6. Morita, H., Minowa, T., Hanagata, N. ｢骨芽細胞特異的膜タンパク質IFITM5の機能解析：プロモーター領域の解析 / Functional Analysis of Osteoblast-Specific Membrane Protein IFITM5: Analysis of promoter region｣ 第32回日本分子生物学会年会 (2009)
  7. Li, J., Maeda, M., Minowa, T. and Hanagata, N. ｢骨芽細胞特異的膜タンパク質IFITM5の機能解析：ノックアウトマウスの解析 / Functional Analysis of Osteoblast-Specific Membrane Protein IFITM5: Analysis of homogeneous mutant mice of IFITM5｣ 第32回日本分子生物学会年会 (2009)
  8. Hanagata, N. ｢ナノテクノロジー・ネットワークにおける取り組みと産学官研究者支援によるイノベーション創出 / ナノテクノロジー・ネットワークにおける取り組みと産学官研究者支援によるイノベーション創出｣ 第2回東北大学医学系NM-GCOE拠点シンポジウム (2009)
  9. Onogawa, T., Maeda, S., Okaue, T., Takadate, T., Ishida, K., Maeda, M., Takemura, T., Mikami, S., Endo, Y., Yamada, S., Nishiyama, R., Minowa, T., Hanagata, N., et. al. ｢胆道癌ホルマリン固定パラフィン包埋組織切片からのディスカバリープロテオミクス / Discovery proteomics using formain-fixed paraffin-embedded tissues of cholangiocarcinoma｣ 日本ヒトプロテオーム機構（JHUPO）第7回大会 (2009)
  10. Tsukamoto, T., Li, X., Kamiya, M., Hanagata, N. and Demura, M. ｢Structureal study of Ifitm5, a human double transmembrane protein; optimization for NMR sample preparation｣ 第47回日本生物物理学会年会 (2009)
  11. Ohya, K., Takemura, T., Hanagata, N., Moriyama, Y., Noda, K., Tsutsumi, Y., Doi, H., Nomura, N. and Hanawa, T. ｢チタン、ジルコニウム、金における骨芽細胞様細胞骨分化特性の網羅的遺伝子発現解析｣ 日本金属学会2009年秋期講演大会 (2009)
  12. Onogawa, T., Maeda, S., Okaue, T., Morikawa, T., Takadate, T., Ishida, K., Maeda, M., Takemura, T., Mikami, S., Endo, Y., Yamada, S., Nishiyama, R., Minowa, T., Hanagata, N., et. al. ｢胆道癌ホルマリン固定パラフィン包埋（FFPE）組織からのディスカバリープロテオミクス / Discovery proteomics using formain-fixed paraffin-embedded tissues of cholangiocarcinoma｣ 第5回 日本臨床プロテオーム研究会 (2009)
  13. 大家渓、竹村太郎、堤祐介、土居壽、野村直之、花方信孝、塙隆夫　「骨芽細胞様細胞の遺伝子発現の金属種類による相違」 第31回日本バイオマテリアル学会 （2009）
  14. 吉江幸子，池畑政輝，廣田憲之，竹村太郎，箕輪貴司，花方信孝，早川敏雄　「SOD欠損大腸菌を用いた定常磁場13Tの変異原性評価」 放射線影響学会　(2009)

2008

【Publications】
  1. Ikoma, I., Yoshioka, T., Nakayama, S., Hanagata, N., Abe, T., Sakane, M., Ochiai, N. and Tanaka, J.　Rigid hydroxyapatite-alginate beads for sustainable release of paclitaxel　Key Engineering Materials 361-363: 535-538 (2008)
  2. Tonegawa, T., Ikoma, T., Yoshioka, T., Chen, G., Hanagata, N., Tanaka, J.　Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite Key Engineering Materials 361-363: 187-190 (2008)
  3. Takemura, T., Ikoma, I. and Hanagata, N.  Effect of acid treated hydroxyapatite on osteoblast maturation Key Engineering Materials 361-363: 1029-1031 (2008)
  4. oshioka,T., Ikoma, T., Monkawa, A., Tonegawa, T., Hanagata, N., Chakarov, D., Kasemo, B. and Tanaka, J. Proteins adsorption on hydroxyapatite nano-crystals with quartz crystal microbalance technique Key Engineering Materials 361-363: 1119-1122 (2008)
【Invited Review Papers】
  1. 大熊恒雄、清水恭子、渡邉和彦、箕輪貴司、花方信孝　「産官学が連携して開発した「キトサン・ナノ繊維を用いた細胞培養基材」 WEB JOURNAL 　Vol.92： 38-41（2008）
  2. 小暮亮雅、粉川良平、藤井岳直、紋川亮、生駒俊之、竹村太郎、花方信孝、田中順三　「ナノサーチ顕微鏡による細胞外マトリックスの観察」 島津評論 　64巻3.4号 131-137 （2008）
【International Conferences】
  1. Tagaya, M., Ikoma, T., Takemura, T., Okuda, M., Yoshioka, T., Chakarov, D., Kasemo, B., Tanaka, J. Adsorption of Proteins Derived from Fetal Bovine Serum onto Hydroxyapatite Nanocrystals with Quartz Crystal Microbalance Techniq. 21st International Symposium of Ceramics in Medicine, Búzios,Burazil   Oct 21 – 24  (2008)
  2. Tonegawa, T., Ikoma, T., Yoshioka, T., Shinozaki, K., Hanagata, N., Tanaka, J. Adsorption and Sustained Release of Insulin from Zinc Hydroxyapatite Microparticle with Poly(Lactic acid)Coating. International Symposium of Ceramics in Medicine, Búzios,Burazil   Oct 21 – 24  (2008)
  3. Ikoma, T., Tagaya, M., Tonegawa, T., Okuda, M., Hanagata, N., Yoshioka, T., Chakarov, D., Tanaka, J. The Surface Property of Hydroxyapatite: Sensing with Quartz Crystal Microbalance. International Symposium of Ceramics in Medicine, Búzios,Burazil   Oct 21 – 24  (2008)
  4. Tonegawa, T., Ikoma, T., Yoshioka, T., Shinozaki, K., Hanagata, N., Tanaka, J. Pharmacological Protein Adsorption on Nano Crystalline Zinc containing Hydroxyapatite. 8th World Biomaterials Congress, Amsterdam,,Netherland  May 28-June 01 (2008)
  5. Ikoma, T., Hanagata, J., Tanaka, J. Protein Nanofilms Patterned on Hydroxyapatite. 8th World Biomaterials Congress, Amsterdam, Netherland.  May 28-June 01 (2008)
【Domestic Conferences】
  1. 山吉誠也, 山下康子, 花方信孝, 箕輪貴司, 竹村太郎, 清水博之, 小池智 「エンテロウイルス71の感染性決定分子の同定」 第56回 日本ウイルス学会学術集会　(2008)
  2. 利根川亨, 生駒俊之, 吉岡 朋彦, 篠崎 和夫, 花方信孝, 田中順三 「結晶子サイズの異なる水酸アパタイトのタンパク質吸着能評価」 日本セラミックス協会 第21回秋季シンポジウム（2008）
  3. 吉江幸子, 池畑政輝, 早川敏雄, 廣田憲之, 竹村太郎, 箕輪貴司, 花方信孝 「活性酸素除去機能を欠損する大腸菌による強磁場13Tの変異原性評価」 第32回日本磁気学会学術講演会  (2008)
  4. 吉江幸子, 池畑政輝, 早川敏雄, 廣田憲之, 竹村太郎, 箕輪貴司, 花方信孝 「活性酸素除去機能を欠損する大腸菌による強磁場13 Ｔの変異原性評価 」日本磁気科学会第3回年次大会  (2008)
  5. 李香蘭, 箕輪貴司, 花方信孝 「骨芽細胞特異的膜タンパク質IFITM5と相互作用するタンパク質の同定」 第31回日本分子生物学会年会 (2008)
  6. 森田浩美, 竹村太郎, 李香蘭, 箕輪貴司, 花方信孝 「骨芽細胞特異的な新奇遺伝子Ifitm5」 第31回日本分子生物学会年会  (2008)
  7. Zhang, L., 花方信孝, 前田めぐみ箕輪貴司, Fan, H., Zhang, X. Osteoblast induction by porous calcium phosphate ceramics implanted into rat muscle. 日本バイオマテリアル学会シンポジウム (2008 )
  8. 高森靖, 箕輪貴司, Segawa, Y., Takao, T., Suzuki, K., Asai, Y., Nogaki, K., 花方信孝 「臍帯血由来CD133陽性細胞におけるES関連遺伝子の発現と臍帯由来細胞を用いた幹細胞性の維持」 第38回日本免疫学会学術集会  (2008)

2007

【Publications】
  1. Hanagata, N., Takemura, T. Monkawa, A., Ikoma, T. and Tanaka, J.　Phenotype and gene expression pattern of osteoblast-like cells cultured on polystyrene and hydroxyapatite pre-adsorbed with type-I collagen　Journal of Biomedical Matrials Research Part A 82A (2): 362-371 (2007)
  2. Miyama, M. and Hanagata, N.　Microarray Gene Expression Profiling for Salt Tolerant Gene Selection　Plant Stress 1 (1): 118-122 (2007)
  3. Miyama, M. and Hanagata, N.　Microarray analysis of 7,029 gene expression patterns in burma mangrove under high-salinity stress　Plant Sicence 172: 948-957 (2007)
  4. Yunoki S, Ikoma T, Monkawa A, Marukawa E, Sotome S, Shinomiya K, Tanaka J. Three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity. Journal of Biomaterials Science-Polymer Edition 18 (4): 393-409 (2007)
  5. Zhu XD, Fan HS, Zhao CY, Lu J, Ikoma T, Tanaka J, Zhang XD. Competitive adsorption of bovine serum albumin and lysozyme on characterized calcium phosphates by polyacrylamide gel electrophoresis method. Journal of Materials Science-Materials in Medicine 18 (11): 2243-2249 (2007)
  6. Yunoki S, Marukawa E, Ikoma T, Sotome S, Fan HS, Zhang XD, Shinomiya K, Tanaka J. Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites. Journal of Materials Science-Materials in Medicine 18 (11) : 2179-2183 (2007)
  7. Kino R, Ikoma T, Yunoki S, Nagai N, Tanaka J, Asakura T, Munekata M. Preparation and characterization of multilayered hydroxyapatite/silk fibroin film. Journal of Bioscience and Bioengineering 103: 514-520 (2007)
  8. Yunoki S, Ikoma T, Tsuchiya A, Monkawa A, Ohta K, Sotome S, Shinomiya K, Tanaka J. Fabrication and mechanical and tissue ingrowth properties of unidirectionally porous hydroxyapatite/collagen composite. Journal of Biomedical Materials Research: Applied Biomaterials80B (1) : 166-173 (2007)
  9. Yunoki S, Ikoma T, Monkawa A, Ohta K, Tanaka J. Preparation and characterization of hydroxyapatite/collagen nanocomposite gel. Journal of Nanoscience and Nanotechnology 7 (3): 818-821 (2007)
  10. Monkawa A, Ikoma T, Yunoki S, Ohta K, Tanaka J. Collagen coating on hydroxyapatite surfaces modified with organosilane by chemical vapor deposition (CVD) method. Journal of Nanoscience and Nanotechnology 7 (3): 833-838 (2007)
  11. Ikoma T, Tonegawa T, Watanabe H, Chen GP, Tanaka J, Mizushima Y. Drug-supported microparticle of calcium carbonate nanocrystals and its covering with hydroxyapatite. Journal of Nanoscience and Nanotechnology 7 (3): 822-827 (2007)
  12. Fan H, Ikoma T, Tanaka J, Zhang X. Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterials. Journal of Nanoscience and Nanotechnology 7 (3): 808-813 (2007)
  13. Tonegawa T, Ikoma T, Chen GP, Tanaka J. Synthesis and characterization of metal ions containing hydroxyapatite microparticles with high specific surface area. Journal of Nanoscience and Nanotechnology 7(3): 839-843 (2007)
  14. Takemura, T., Monkawa, A., Ikoma, Y., Tanaka, J. and Hanagata, N.　Gene expression profile of osteoblast-like cells on calcium phosphate biomaterials　Key Engineering Materials 330-332: 1087-1090 (2007)
  15. Abe T, Sakane M, Ikoma T, Yoshioka T, Tanaka J, Ochiai N. Novel chemoprevention with paclitaxel loaded hydroxyapatite-alginate particles for paralysis in metastatic spine cancer in rats. Clinical & Experimental Metastasis 24 (4): 284-285 (2007)
  16. Abe T, Sakane M, Ikoma T, Tonegawa T, Yoshioka T, Tanaka J. Novel Local Treatment with Paclitaxel-loaded Hydroxyapatite-alginate gels for spinal bone metastases. Key Engineering Materials 330-332: 1343-1346 (2007)
  17. Yoshioka T, Ikoma T, Monkawa A, Yunoki S, Abe T, Sakane M, Tanaka J. Preparation of hycroxyapatite-alginate gels as a carrier for controlled release of Paclitaxel. Key Engineering Materials 330-332: 1053-1056 (2007)
  18. Suetsugu Y, Hotta Y, Iwasashi M, Sanake M, Kikuchi M, Ikomat T, Higaki T, Ochiai N, Tanaka J. Structural and tissue reaction properties of novel hydroxyapatite ceramics with unidirectional pores. Key Engineering Materials 330-332: 1003-1006 (2007)
  19. Takemura T, Fan H, Ikoma T, Tanaka J, Hanagata N. Gene expression profile of osteoblast like cells on calcium phosphate biomaterials. Key Engineering Materials 330-332: 1087-1090 (2007)
  20. Tonegawa T, Ikoma T, Chen G, Tanaka J. Control of protein initial burst from zinc-hydroxyapatite /poly(L-lactide)system. Key Engineering Materials 330-332 857-860 (2007)
  21. Watanabe H, Ikoma T, Chen G, Tanaka J. Hydroxyapatite/chondroitin sulfate microparticles as time-controlled release carrier of proteins. Key Engineering Materials 330-332: 1009-1012 (2007)
【Invited Review Papers】
  1. 川上亘作, 生駒俊之, 田口哲志, 谷口彰良, 陳国平, 花方信孝, 内田義之, 立石哲也　「次世代DDS型治療システム創成に向けた取り組み / 次世代DDS型治療システム創成に向けた取り組み」　WEB Journal, Vol.84/ Page 35～38 (2007)
  2. 生駒俊之、花方信孝、利根川亨、吉岡朋彦、田中順三　「ホメオスタシスを調整する生体無機材料」Materials Integration 第20巻　第11号　14-19　(2007）
  3. 花方信孝「網羅的遺伝子発現解析による生体材料のin vitro評価」　Materials Integration 第20巻　第11号　101-106　(2007)
【International Conferences】
  1. Reiter, M., Hanagata, N., and Plasek, J. Structural changes of yeast cell wall cultured in different glucose concentration. European Biophysics Congress, Imperial College London, London, UK, July 14-18 ( 2007)
  2. Reiter, M., Ikoma, T., Hanagata, N., and Roguska, A. Formation of type I collagen fibrils from porcine dermis and fish scale observed by AFM. Nanostructured Polymers and Polymer Nanocomposites , Institute of Macromolecular Chemistry Academy of Sciences of  CR,Prague, Czech Republic, July 08-12 (2007)
  3. Yoshie, S., Ikehara, M., Hirota, N., Takemura, T., Minowa, T., Hanagata, N., and Hayakawa, T.
    Effects of statistic magnetic field on Escherichia coli deficient in superoxide dismutase International Conference on Magno-Science, Hiroshima, Nov. 11-15 ( 2007)
  4. Ikoma, I., Yoshioka, T., Nakayama, S., Hanagata, N., Abe, T., Sakane, M., Ochiai, N. and Tanaka, J. Rigid hydroxyapatite-alginate beads for sustainable release of paclitaxel The 20th International Symposium on Ceramics in Medicine, Citedes Congres, Nant, France, Oct. 22-28 (2007)
  5. Tonegawa, T., Ikoma, T., Yoshioka, T., Chen, G., Hanagata, N., Tanaka, J. Characterization and protein adsorption ability of zinc, iron and magnesium hydroxyapatite The 20th International Symposium on Ceramics in Medicine, Citedes Congres, Nant, France, Oct. 22-28 (2007)
  6. Takemura, T., Ikoma, I. and Hanagata, N. Effect of acid treated hydroxyapatite on osteoblast maturation The 20th International Symposium on Ceramics in Medicine, Citedes Congres, Nant, France, Oct. 22-28 ( 2007)
  7. Yoshioka,T., Ikoma, T., Monkawa, A., Tonegawa, T., Hanagata, N., Chakarov, D., Kasemo, B. and Tanaka, J. Proteins adsorption on hydroxyapatite nano-crystals with quartz crystal microbalance technique The 20th International Symposium on Ceramics in Medicine, Citedes Congres, Nant, France, Oct. 22-28 (2007)
  8. Takemura, T. and Hanagata, N. Stimulation of osteoblast maturation by acid treated hydroxyapatite surface 1st Asian Biomaterials Congress, Tsukuba, Japan, Dec. 6-8 (2007)
【Domestic Conferences】
  1. 吉江幸子、池端政輝、早川敏雄、廣田憲之、竹村太郎、箕輪貴司、花方信孝　「定常磁場のSOD欠損大腸菌による変異原性評価」　 電気学会マグネティックス研究会、東京大学柏キャンパス (2007)
  2. 高森靖、鈴木恵子、浅井芳明、野垣兼朗、竹村太郎、花方信孝　「 Stem Cell Gene Expression on Cord Blood Cells with the Lapse of Time after Harvest / Stem Cell Gene Expression on Cord Blood Cells with the Lapse of Time after Harvest」　 第37回日本免疫学会総会 、グランドプリンスホテル新高輪　東京　 (2007)
  3. 横山敬郎、竹村太郎、花方信孝、小林尚俊 　「 高分子-タンパク混紡型ナノファイバーの細胞接着性と構造解析」　 第56回高分子学会年次大会 、国立京都国際会館　京都 　(2007)
 

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