Tough, biocompatible surgical sealants for the treatment of pulmonary air leaks

Pulmonary air leaks are medical complications of thoracic surgery for which fi brin sealant is the main treatment. In this study, innovative sealants based on hydrophobically modifi ed Alaska pollock- derived gelatin (hm-ApGltn) and a poly(ethylene)glycol-based 4-armed cross-linker (4S-PEG) have been developed and their burst strengths have been evaluated using fresh rat lung. The developed sealants show higher lung burst strength compared with the nonmodifi ed original ApGltn (Org-ApGltn)-based sealant and a commercial fi brin sealant. The maximum burst strength of the hm-ApGltn-based sealant is 1.6-fold higher than the Org-ApGltn-based sealant ( n = 5, p

Macromol Biosci, 2017, 17, 1600349
Biomater Sci, 2017, 5, 982-989.
J Biomed Nanotechnol, 2016, 12, 128-134.
Colloids Surf B, 2016, 146, 212-220.

Enhanced angiogenesis of growth factor-free porous biodegradable adhesive

The bonding behavior of hexanoyl (Hx: C6) group-modified alkaline-treated gelatin (HxAlGltn) porous films ((P)HxAlGltn) on the porcine intestine was evaluated. (P)HxAlGltns with various porosities were prepared by the salt-leaching method for various solideliquid ratios. (P)HxAlGltns bonded more strongly to porcine intestine surfaces than did porous AlGltn films ((P)AlGltns). L929 cells cultured on (P) HxAlGltns showed adhesivity than cells cultured on (P)AlGltns. Faster tissue infiltration and a shorter degradation time of highly porous (P)HxAlGltns were observed after implantation in rat subcutaneous tissues. The angiogenic markers CD34 and a-SMA were highly expressed around (P)HxAlGltns that had high porosity. These results indicated that highly porous (P)HxAlGltns have advantages with respect to not only bonding strength on wet soft tissues, but also angiogenesis.

Biomaterials, 2015, 63, 14-23.