Hokkaido University – NIMS Joint Graduate School
Frontier Biomaterials Lab

Publications

2025

  1. Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai,Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki. Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides. Biomolecules. 15 [1] (2025) 95 10.3390/biom15010095
  2. Qicheng Zhang, Si Chen, Xiaoting Xue, Solmaz Hajizadeh, Tomohiko Yamazaki, Lei Ye. Cationic Polymer Brushes Functionalized with Carbon Dots and Boronic Acids for Bacterial Detection and Inactivation. ACS Omega (2025) 10.1021/acsomega.5c01507
  3. Yoshihide Tokunou,Tomohiko Yamazaki, Takashi Fujikawa, Akihiro Okamoto. Decoding in-cell respiratory enzyme dynamics by label-free in situ electrochemistry. Proc Natl Acad Sci USA 122 [12] (2025) e2418926122 10.1073/pnas.2418926122

2024

  1. Kazuaki Hoshi, Anh Thi Tram Tu, Miwako Shobo, Karin Kettisen, Lei Ye, Leif Bülow, Yoji Hakamata, Tetsuya Furuya, Ryutaro Asano, Wakako Tsugawa, Kazunori Ikebukuro, Koji Sode, Tomohiko Yamazaki. Potential of Enzymatically Synthesized Hemozoin Analog as Th1 Cell Adjuvant. Nanomaterials, 14 [7] (2024) 1440
  2. Febriana Catur Iswanti, Kurnia Maidarmi Handayani, Ardiana Kusumaningrum, Tomohiko Yamazaki, Diah Handayani, Mohamad Sadikin. Lysosomal enzymes and the oxygen burst capability of monocyte-derived macrophages in active drug-resistant tuberculosis patients in relation to cell attachment. Tuberculosis, 146 (2024) 10249
  3. Shoko Takeuchi, Tomohiko Yamazaki, Katsutoshi Yamaguchi, Fusae Komura, Takahiro Tabata, Hirotaka Nishi, Satomi Azumai, Kanako Miura, Mai Hirokawa, Keisuke Ikemoto, and Kohsaku Kawakami. Toward the Establishment of a Harmonized Physicochemical Profiling Platform for Therapeutic Oligonucleotides: A Case Study for Aptamers Where the Higher-Order Structure Influences Physical Properties. Molecular Pharmaceutics, 21 [7] (2024) 3471-3484
  4. Xia Li, Shinya Hattori, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Inosine pranobex-derived coordination complexes for self-adjuvant, self-carrier, and self-assembled vaccines in cancer immunotherapy. Applied Materials Today. 39 (2024) 102299
  5. Xia Li, Mitsuhiro Ebara, Naoto Shirahata, Tomohiko Yamazaki, Nobutaka Hanagata. Synergistic Effects of Metal–Organic Nanoplatform and Guanine Quadruplex-Based CpG Oligodeoxynucleotides in Therapeutic Cancer Vaccines with Different Tumor Antigens. Vaccines. 12 [6] (2024) 649
  6. Xia Li, Naoto Shirahata, Tomohiko Yamazaki, Nobutaka Hanagata. A rapid strategy to develop personalized cancer nanovaccines for different immunogenic tumors. Journal of Clinical Oncology. 42 [16] (2024) e14670
  7. Chiaki Yoshikawa, Duc Anh Nguyen, Tadashi Nakaji-Hirabayashi, Ichigaku Takigawa, Hiroshi Mamitsuka. Graph Network-Based Simulation of Multicellular Dynamics Driven by Concentrated Polymer Brush-Modified Cellulose Nanofibers. ACS Biomaterials Science and Engineering. 10 [4] (2024) 2165-2176

2023

  1. Nguyen Bui Thao Le, Anh Thi Tram Tu, Dandan Zhao, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki. Influence of the Charge Ratio of Guanine-Quadruplex Structure-Based CpG Oligodeoxynucleotides and Cationic DOTAP Liposomes on Cytokine Induction Profiles. Biomolecules. 13 [11] (2023) 1639 10.3390/biom13111639
  2. Febriana Catur Iswanti, Qarina Hasyala Putri, Ani Retno Prijanti, Samsuridjal Djauzi, Mohamad Sadikin, Arief Budi Witarto, Tomohiko Yamazaki. The Use of Chitosan Nanoparticles for Delivery of CpG ODN in Treatment of Allergic Balb/C Mice. Reports of Biochemistry and Molecular Biology. 11 [4] (2023) 599-613 10.52547/rbmb.11.4.599
  3. Anchu Viswan, Chiaki Yoshikawa, Ayana Yamagishi, Yuichi Furuhata, Yoshio Kato, Tomohiko Yamazaki, Chikashi Nakamura. Efficient genome editing by controlled release of Cas9 ribonucleoprotein in plant cytosol using polymer-modified microneedle array. Biochemical and Biophysical Research Communications. 686 (2023) 149179 10.1016/j.bbrc.2023.149179
  4. Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata. Nanoengineered coordination polymers boost cancer immunotherapy. Materials Today. 67 (2023) 127-150 10.1016/j.mattod.2023.06.001
  5. Usharani Nagarajan, Sourov Chandra, Tomohiko Yamazaki, Naoto Shirahata, Françoise M. Winnik. Analysis of Silicon Quantum Dots and Serum Proteins Interactions Using Asymmetrical Flow Field-Flow Fractionation. Langmuir. 39 [22] (2023) 7557-7565 10.1021/acs.langmuir.3c00109
  6. Tomohiro Murata, Kosuke Minami, Tomohiko Yamazaki, Tomomasa Sato, Hideomi Koinuma, Katsuhiko Ariga, Nobuyuki Matsuki. Nanometer-Flat DNA-Featured Thin Films Prepared via Laser Molecular Beam Deposition under High-Vacuum for Selective Methanol Sensing. Bulletin of the Chemical Society of Japan. 96 [1] (2023) 29-34 10.1246/bcsj.20220303

2022

  1. Anh Thi Tram Tu, Kazuaki Hoshi, Tomohiko Yamazaki. Influence of loop permutation on immunostimulatory activities of CpG oligodeoxynucleotides forming monomeric guanine-quadruplex structures. Biomedical Research and Therapy. 9 [11] (2022) 5410-5417 10.15419/bmrat.v9i11.780
  2. Tomohiro Murata, Kosuke Minami, Tomohiko Yamazaki, Genki Yoshikawa, Katsuhiko Ariga. Detection of Trace Amounts of Water in Organic Solvents by DNA-Based Nanomechanical Sensors. Biosensors. 12 [12] (2022) 1103 10.3390/bios12121103
  3. Dandan Zhao, Anh Thi Tram Tu, Miwako Shobo, Nguyen Bui Thao Le, Chiaki Yoshikawa, Kazuhisa Sugai, Yoji Hakamata, Tomohiko Yamazaki. Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-L-Lysine Induce Antibody Production as Vaccine Adjuvants. Biomolecules. 12 [12] (2022) 1868 10.3390/biom12121868
  4. Renzo A. Fenati, Zifei Chen, Yasuko Yamagishi, Kaori Tsukakoshi, Kazunori Ikebukuor, Anjay Manian, Salvy P. Russo, Tomohiko Yamazaki, Amanda V. Ellis. Enhancement of DNAzymatic activity using iterativein silicomaturation. Journal of Materials Chemistry B. 10 [43] (2022) 8960-8969 10.1039/d2tb01638a
  5. Anh Thi Tram Tu, Kazuaki Hoshi, Yue Ma, Taiji Oyama, Satoko Suzuki, Kaori Tsukakoshi, Kazuo Nagasawa, Kazunori Ikebukuro, Tomohiko Yamazaki. Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. ACS Chemical Biology. 17 [7] (2022) 1703-1713 10.1021/acschembio.1c00904
  6. Clarisse Bloyet, Flavien Sciortino, Yoshitaka Matsushita, Paul A. Karr, Anuradha Liyanage, Wipakorn Jevasuwan, Naoki Fukata, Subrata Maji, Jan Hynek, Francis D’Souza, Lok Kumar Shrestha, Katsuhiko Ariga, Tomohiko Yamazaki, Naoto Shirahata, Jonathan P. Hill, Daniel T. Payne. Photosensitizer Encryption with Aggregation Enhanced Singlet Oxygen Production. Journal of the American Chemical Society. 144 [24] (2022) 10830-10843 10.1021/jacs.2c02596
  7. İrem Nur Gamze Özbilgin, Tomohiko Yamazaki, Junpei Watanabe, Hong-Tao Sun, Nobutaka Hanagata, Naoto Shirahata. Water-Soluble Silicon Quantum Dots toward Fluorescence-Guided Photothermal Nanotherapy. Langmuir. 38 [17] (2022) 5188-5196 10.1021/acs.langmuir.1c02326
  8. Satoshi Migita, Keita Wakabayashi, Tomohiko Yamazaki. Binding stability of peptides to Co–Cr–Mo alloy affects proliferation and differentiation of osteoblast. Biotechnology and Bioengineering. 119 [4] (2022) 1157-1163 10.1002/bit.28041
  9. Xida Yuan, Punnida Nonsuwan, Miwako Shobo, Robin Rajan, Tomohiko Yamazaki, Keita Sakakibara, Kazuaki Matsumura, Chiaki Yoshikawa. Cellular Flocculation Using Concentrated Polymer Brush-Modified Cellulose Nanofibers with Different Fiber Lengths. Biomacromolecules. 23 [3] (2022) 1101-1111 10.1021/acs.biomac.1c01424
  10. Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo, Tomohiko Yamazaki. G-quadruplex-based CpG oligodeoxynucleotide/DOTAP complex strongly stimulates immunity in CpG motif-specific and loop-length-dependent manners. Nanomedicine: Nanotechnology, Biology and Medicine. 40 (2022) 102508 10.1016/j.nano.2021.102508
  11. Sanako Makishi, Tomohiko Yamazaki, Hayato Ohshima. Osteopontin on the Dental Implant Surface Promotes Direct Osteogenesis in Osseointegration. International Journal of Molecular Sciences. 23 [3] (2022) 1039 10.3390/ijms23031039
  12. Chiaki Yoshikawa, Keita Sakakibara, Punnida Nonsuwan, Miwako Shobo, Xida Yuan, Kazuaki Matsumura. Cellular Flocculation Driven by Concentrated Polymer Brush-Modified Cellulose Nanofibers with Different Surface Charges. Biomacromolecules. 23 [8] (2022) 3186-3197 10.1021/acs.biomac.2c00294
  13. Chiaki Yoshikawa, Ryoma Takagi, Tadashi Nakaji-Hirabayashi, Toshiro Ochi, Yasushi Kawamura, Helmut Thissen. Marine Antifouling Coatings Based on Durable Bottlebrush Polymers. ACS Applied Materials & Interfaces. 14 [28] (2022) 32497-32509 10.1021/acsami.2c06647
  14. Punnida Nonsuwan, Nanami Nishijima, Keita Sakakibara, Tadashi Nakaji-Hirabayashi, Chiaki Yoshikawa. Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly. Journal of Materials Chemistry B. 10 [14] (2022) 2444-2453 10.1039/d1tb02307a

2021

  1. Fika Ayu Safitri, Anh Thi Tram Tu, Kazuaki Hoshi, Miwako Shobo, Dandan Zhao, Arief Budi Witarto, Sony Heru Sumarsono, Ernawati Arifin Giri-Rachman, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki. Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold. Biomolecules. 11 [11] (2021) 1617 10.3390/biom11111617
  2. Dinh Ngoc Pham, Sachiko Hiromoto, Tomohiko Yamazaki, Minho O, Equo Kobayashi. Enhanced Corrosion Resistance and In Vitro Biocompatibility of Mg-Zn Alloys by Carbonate Apatite Coating. ACS Applied Bio Materials. 4 [9] (2021) 6881-6892 10.1021/acsabm.1c00594
  3. Chiaki Yoshikawa, Keita Sakakibara, Punnida Nonsuwan, Tomohiko Yamazaki, Yoshinobu Tsujii. Nonbiofouling Coatings Using Bottlebrushes with Concentrated Polymer Brush Architecture. Biomacromolecules. 22 [6] (2021) 2505-2514 10.1021/acs.biomac.1c00247
  4. Chiaki Yoshikawa, Shinya Hattori, Chih-Feng Huang, Hisatoshi Kobayashi, Masaru Tanaka. In vitro and in vivo blood compatibility of concentrated polymer brushes. Journal of Materials Chemistry B. 9 [29] (2021) 5794-5804 10.1039/d1tb00886b
  5. Keita Sakakibara, Keishi Maeda, Chiaki Yoshikawa, Yoshinobu Tsujii. Water Lubricating and Biocompatible Films of Bacterial Cellulose Nanofibers Surface-Modified with Densely Grafted, Concentrated Polymer Brushes. ACS Applied Nano Materials. 4 [2] (2021) 1503-1511 10.1021/acsanm.0c03014
  6. Chiaki Yoshikawa, Tadashi Nakaji-Hirabayashi, Nanami Nishijima, Punnida Nonsuwan, Rou Jun Toh, Wioleta Kowalczyk, Helmut Thissen. Ultra-low fouling photocrosslinked coatings for the selective capture of cells expressing CD44. Materials Science and Engineering: C. 120 (2021) 111630 10.1016/j.msec.2020.111630

Publications before 2020

https://samurai.nims.go.jp/