Porous HAp/Col Bone Void FIller
The HAp/Col posous body deforms like sponge under wet conditions, that is similar conditions to implant, as shown in right movie.
Therefore, the HAp/Col porous body can fit into bone defects of various shapes and accelerate bone regeneration, unlike conventional hard ceramic bone fillers
Furthermore, deforming and returning shape of the porous HAp/Col in a cell suspension such as osteoblasts easily introduce the cell suspension into the porous material.
The HAp/Col porous body is a bone filler with unprecedented functions, including incorporated into bone remodeling process, and is used in orthopedics as well as dentistry in Japan.
Human osteoblastic MG-63 cells cultured in HAp/Col porous body produced calcium phosphates, the main inorganic component of bone, on the 21st day. This phenomenon was not observed in MG-63 cells cultured in collagen sponges for the same period and under the same conditions.
Gene expression results suggested the cells did not only secreted calcium phosphate, and the cells in the HAp/Col porous body would be influenced by the surrounding environment and secreted substances similar to bone.
A similar phenomenon would occur when the HAp/Col implanted in bone is substituted with new bone. threfore, we are currently conducting a detailed study of the initial reaction of HAp/Col within bone defects together with Professors Norio Amitsuka and Tomoka Hasegawa of the Hokkaido University Graduate School of Dentistry, who are experts in bone formation.