National Institute for Materials Science (NIMS)
International Center for Materials Nanoarchitectonics (MANA)
Supermolecules Group
Senior Scientist

1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
Phone: +81-29-860-4892
Fax: +81-29-860-4832


Gender: Female

Birth: March 14, 1978, Wakayama, Japan

Nationality: Japan


Research areas:

Synthetic chemistry, physical organic chemistry, and interfacial chemistry



2000      Bachelor (Pharmaceutical Sciences)

              The University of Tokyo   Graduate School of Pharmaceutical Sciences,           Faculty of Pharmaceutical Sciences  

2002      Master (Pharmaceutical Sciences)

              The University of Tokyo   Graduate School of Pharmaceutical Sciences,           Faculty of Pharmaceutical Sciences  

2005      Ph. D. (Chemistry)

              The University of Tokyo   Department of Chemistry, School of Science            


Work experience:


              COE Research Assistant  

              The University of Tokyo (Professor Eiichi Nakamura)


              JSPS Research Fellow for Young Scientist

              The University of Tokyo (Professor Eiichi Nakamura)


              Research Associate

              Chiba University (Professor Tsutomu Ishikawa)


              Assistant Professor

              Chiba University (Professor Tsutomu Ishikawa)


              JSPS Research Fellow in Bilateral Programs

              University of Alberta, Canada (Professor F. G. West)


              Senior Lecturer  

              Tohoku University (Professor Hiroyuki Isobe)


              Senior Scientist (MANA Scientist)

              NIMS, MANA, Supermolecules group (Dr. Katsuhiko Ariga)



2008      Inoue Research Award for Young Scientists

              New Transfection Method Based on Cationic Fullerene Assembly

2008      Nissan Chemical Industries Award in Synthetic Organic Chemistry, Japan

              Construction and Application of Helical Structure Based on Control of           Configuration of Guanidine

2010      The Chemical Society of Japan, Tohoku Region, Poster Award

              Disilanyl Double-Pillared Bisanthracene: A Bipolar Charge Transport Material               for Organic Light Emitting Diode Devices

2017      The Young Scientist Award of The Division of Colloid and Surface Chemistry, The Chemical Society of Japan

              Dynamic control of molecular structures and assemblies at interfaces and their functions





Grant-in-Aid for JSPS Fellows, JSPS, 1,000,000 yen

Development of Fullerene Transfection Reagent



Grant-in-Aid for Young Scientists (B), JSPS, 3,450,000 yen

Asymmetric Crystallization and Application of Functionalized Molecules



Grant-in-Aid for JSPS Research Fellow in Bilateral Programs, JSPS

Development of Synthetic Method for Construction of Asymmetric Cycles Based on Hydrogen Bondings



Grant-in-Aid for Scientific Research (C), JSPS, 4,680,000 yen

Development of Organic Semiconductor Based on Efficient Synthesis of Polycyclic Aromatic Hydrocarbons



NIMS Inter Unit Seeds Development Research, 20,000,000 yen



Grant-in-Aid for Scientific Research on Innovative Areas, 7,020,000 yen

Development of assembled structures of nonplanar conjugated molecules based on dynamic analysis



Grant-in-Aid for Research Activity start-up, JSPS, 2,300,000 yen

Dynamic control of molecular structures and functions at the air-water interface




List of publications

[Original papers]


(1)          Nakanishi, W.; Kikuchi, K.; Inoue, T.; Hirose, K.; Iino, M.; Nagano, T., Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding. Bioorg. Med. Chem. Lett. 2002, 12 (6), 911-913.


(2)          Nakanishi, W.; Yamanaka, M.; Nakamura, E., Reactivity and stability of organocopper(I), silver(I), and gold(I) ate compounds and their trivalent derivatives. J. Am. Chem. Soc. 2005, 127 (5), 1446-1453.


(3)          Isobe, H.; Tanaka, T.; Nakanishi, W.; Lemiegre, L.; Nakamura, E., Regioselective oxygenative tetraamination of [60]fullerene. Fullerene-mediated reduction of molecular oxygen by amine via ground state single electron transfer in dimethyl sulfoxide. J. Org. Chem. 2005, 70 (12), 4826-4832.


(4)          Ying, Q.; Zhang, J.; Liang, D.; Nakanishi, W.; Isobe, H.; Nakamura, E.; Chu, B., Fractal behavior of functionalized fullerene aggregates. I. Aggregation of two-handed tetraaminofullerene with DNA. Langmuir 2005, 21 (22), 9824-9831.


(5)          Isobe, H.; Nakanishi, W.; Tomita, N.; Jinno, S.; Okayama, H.; Nakamura, E., Nonviral gene delivery by tetraamino fullerene. Mol. Pharm. 2006, 3 (2), 124-134.


(6)          Isobe, H.; Nakanishi, W.; Tomita, N.; Jinno, S.; Okayama, H.; Nakamura, E., Gene delivery by aminofullerenes: structural requirements for efficient transfection. Chem. Asian J. 2006, 1, (1-2), 167-175.


(7)          Nakanishi, W.; Ishikawa, T.; Margetic, D., Approaches to the potential chirality of bisguanidinobenzenes by dynamic NMR analysis. Bull. Chem. Soc. Jpn. 2007, 80 (6), 1187-1193.


(8)          Margetic, D.; Nakanishi, W.; Kumamoto, T.; Ishikawa, T., Quantum-chemical study of 1,2-bis(dimethylethyleneguanidino)benzenes. Heterocycles 2007, 71 (12), 2639-2658.


(9)          Nakanishi, W.; Ogino, A.; Kawahata, M.; Yamaguchi, K.; Ishikawa, T., Asymmetric crystallization of bisguanidinobenzene derivatives. Tetrahedron Lett. 2007, 48 (48), 8526-8530. (Selected as a cover.)


(10)        Kurokawa, M.; Nakanishi, W.; Ishikawa, T., Copper(I) iodide-catalyzed coupling reaction of haloindoles with alpha -amino acids. Heterocycles 2007, 71 (4), 847-854.


(11)        Etomi, N.; Kumamoto, T.; Nakanishi, W.; Ishikawa, T., Diels-Alder reactions using 4,7-dioxygenated indanones as dienophiles for regioselective construction of oxygenated 2,3-dihydrobenz[f]indenone skeleton. Beilstein J. Org. Chem. 2008, 4, 15.


(12)        Zhang, G.; Shimokawa, S.; Mochizuki, M.; Kumamoto, T.; Nakanishi, W.; Watanabe, T.; Ishikawa, T.; Matsumoto, K.; Tashima, K.; Horie, S.; Higuchi, Y.; Dominguez, O. P., Chemical constituents of aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. J. Nat. Prod. 2008, 71 (7), 1167-1172.


(13)        Saito, N.; Ryoda, A.; Nakanishi, W.; Kumamoto, T.; Ishikawa, T., Guanidine-catalyzed asymmetric synthesis of 2,2-disubstituted chromane skeletons by intramolecular oxa-Michael addition. Eur. J. Org. Chem. 2008, 2008 (16), 2759-2766.


(14)        Ryoda, A.; Yajima, N.; Haga, T.; Kumamoto, T.; Nakanishi, W.; Kawahata, M.; Yamaguchi, K.; Ishikawa, T., Optical resolution of (+-)-1,2-bis(2-methylphenyl)ethylene-1,2-diamine as a chiral framework for 2-iminoimidazolidine with 2-methylphenyl pendant and the guanidine-catalyzed asymmetric Michael reaction of tert-butyl diphenyliminoacetate and ethyl acrylate. J. Org. Chem. 2008, 73 (1), 133-141.


(15)        Kumamoto, T.; Nagayama, S.; Hayashi, Y.; Kojima, H.; David, L.; Nakanishi, W.; Ishikawa, T., Epimerization of trans-3-arylaziridine-2-carboxylates at the C3 position. Heterocycles 2008, 76 (2), 1155-1170.


(16)        Sugiyama, H.; Kumamoto, T.; Suganami, A.; Nakanishi, W.; Sowa, Y.; Takiguchi, M.; Ishikawa, T.; Tamura, Y., Insight into estrogenicity of phytoestrogens using in silico simulation. Biochem. Biophys. Res. Commun. 2009, 379 (1), 139-144.


(17)        Suda, K.; Saito, N.; Kumamoto, T.; Nakanishi, W.;  Kawahata, M.; Yamaguchi, K.; Ogura, Y.; Suzuki, T. K.; Ishikawa, T., Semi-quantitative approaches to the coordination ability of o-bisguanidiniobenzenes with metal salts. Heterocycles 2009, 77 (1), 375-387.


(18)        Fusegi, K.; Kumamoto, T.; Nakanishi, W.; Ishikawa, T., Dihydroxylation of functionalized coumarin derivatives. Heterocycles 2009, 77 (1), 603-610.


(19)        Nozawa, Y.; Harada, K.; Ryoda, A.; Kumamoto, T.; Nakanishi, W.; Ishikawa, T., Optical resolution of 1,2-diamino compounds using advanced Marfey's method. J. Mass Spectrom. Soc. J. 2009, 57 (2), 71-74.


(20)        Watanabe, D.; Kerakawati, R.; Morita, T.; Nakamura, T.; Ueno, K.; Kumamoto, T.; Nakanishi, W.; Ishikawa, T.; Uzawa, J.; Seki, H.; Tachi, M.; Harada, K.; Higuchi, Y.; Chaichantipyuth, C., Isolation of beta-sitosterol and digalactopyranosyl-diacylglyceride from Citrus hystrix, a Thai traditional herb, as pancreatic lipase inhibitors. Heterocycles 2009, 78 (6), 1497-1505.


(21)        Akagi, Y.; Yamada, S.; Etomi, N.; Kumamoto, T.; Nakanishi, W.; Ishikawa, T., Synthetic studies on jadomycins: Synthesis of dimethyljadomycin A. Tetrahedron Lett. 2010, 51 (9), 1338-1340.


(22)        Kumamoto, T.; Shikii, K.; Kawahata, M.; Yamaguchi, K.; Nakanishi, W.; Ishikawa, T.; Seki, H., Characterization of various o-bisguanidinobenzene-benzoic acid complexes in solid and in solution states. Heterocycles 2010, 80 (1), 303-311.


(23)        Fujino T.; Tsunaka, N.; Guillot-Nieckowski, M.; Nakanishi, W.; Iwamoto, T.; Nakamura, E.; Isobe, H., Synthesis and structures of deoxyribonucleoside analogues for triazole-linked DNA (TLDNA). Tetrahedron Lett. 2010, 51 (15), 2036-2038.


(24)        Maeda-Mamiya, R.; Noiri E.; Isobe, H.; Nakanishi, W.; Okamoto, K.; Doi, K.; Sugaya, K.; Izumie, T.;  Homma, T.; Nakamura, E., In vivo gene delivery by cationic tetraamino fullerene. Proc. Natl. Acad. Sci. USA 2010, 107 (12), 5339-5344.


(25)        Ito, T.; Suda, S.; Kumamoto, T.; Nakanishi, W.; Watanabe, T.;  Ishikawa, T.; Seki, H.; Kawahata, M.; Yamaguchi, K.; Ogura, Y.; Suzuk, K. T., Complexability of o-bisguanidinobenzenes with arsenic and phosphoric acids in solution and solid states, and the potential use of their immobilized derivatives as solid base ligands for metal salts and arsenic acid. Mol. Divers. 2010, 14, 131-145.


(26)        Nakanishi, W.; Hitosugi, S.; Piskareva, A.; Shimada, Y.; Taka, H.; Kita, H.; Isobe, H. Disilanyl double-pillared bisanthracene: A bipolar carrier transport material for organic light emitting diode devices. Angew. Chem. Int. Ed. 2010, 49 (40), 7239-7242.


(27)        Nakanishi, W.; Hitosugi, S.; Piskareva, A.; Isobe, H. 1,8-Diiodoanthrancene. Acta Crystallogr., Sect. E: Struct. Rep. Online 2010, E66 (10), o2515.


(28)        Nakanishi, W.; Hitosugi, S.; Shimada, Y.; Isobe, H. Double-pillaring strategy for silacyclophanes: Synthesis and structures of disilanyl double-pillared bisanthracenes. Chem. Asian J. 2011, 6 (2), 554-559.


(29)       Isobe, H.; Yamazaki, N.; Asano, A.; Fujino, T.; Nakanishi, W.; Seki, S. Electron mobility in a mercury-mediated duplex of triazole-linked DNA (TLDNA). Chem. Lett. 2011, 40 (3), 318-319.


(30)        Nakanishi, W.; Yoshioka, T.; Taka, H.; Xue, J. Y.; Kita, H.; Isobe, H. [n]Cyclo-2,7-naphthylenes: Synthesis and isolation of macrocyclic aromatic hydrocarbons having bipolar carrier transport ability. Angew. Chem. Int. Ed. 2011, 50 (23), 5323-5326.


(31)        Nakanishi, W.; Matsuno, T.; Ichikawa, J.; Isobe, H. Illusory molecular expression of "Penrose stairs" by an aromatic hydrocarbon, Angew. Chem. Int. Ed. 2011, 50 (27), 6048-6051.


(32)        Nakanishi, W.; Xue, J. Y.; Yoshioka, T.; Isobe, H. [6]Cyclo-2,7-naphthylene: a redetermination. Acta Crystallogr., Sect. E: Struct. Rep. Online 2011, E67 (7), o1762-o1763.


(33)        Hitosugi, S.; Nakanishi, W.; Yamasaki, T.; Isobe, H. Bottom-up synthesis of finite models of helical (n,m)-single-wall carbon nanotubes. Nat. Commun. 2011, 2 (10), doi: 10.1038/ncomms1505.


(34)        Hitosugi, S.; Nakamura, Y.; Matsuno, T.; Nakanishi, W.; Isobe, H. Iridium-catalyzed direct borylation of phenacenes. Tetrahedron Lett. 2012, 53 (9), 1180-1182.


(35)        Nakanishi, W.; Shimada, Y.; Taka, H.; Kita, H.; Isobe, H. Synthesis of disilanyl double-pillared bisdibenzofuran with a high triplet energy. Org. Lett. 2012, 14 (6), 1636-1639.


(36)        Hitosugi, S.; Nakanishi, W.; Isobe, H. Atropisomerism in a belt-persistent nanohoop molecule: Rotational restriction forced by macrocyclic ring strain. Chem. Asian J. 2012, 7 (7), 1550-1552. (Selected as a cover.)


(37)        Isobe, H.; Matsuno, T.; Hitosugi, S.; Nakanishi, W. 2,11-Dibromo-5,8-dibutyl[4]helicene, Acta Crystallogr., Sect. E: Struct. Rep. Online 2012, E68 (4), o1239.


(38)        Hitosugi, S.; Tanimoto, D.; Nakanishi, W.; Isobe, H. A facile chromatographic method for purification of pinacol boronic esters. Chem. Lett. 2012, (9), 972-973.


(39)        Nakanishi, W.; Kamata, S.; Hitosugi, S.; Isobe, H., Flexible silacyclophanes with two tricyclic aromatic units linked by two disilanyl pillars, Chem. Lett. 2012, 41 (12), 1652-1654.


(40)        Kojima, H.; Takahata, C.; Lemin, D.; Takahashi, M.; Kumamoto, T.; Nakanishi, W.; Suzuki, N.; Ishikawa, T. Synthesis of the Aziridinomitosene skeleton by application of guanidinium ylide-mediated aziridination. Helv. Chim. Acta, 2013, 96, 379-388.


(41)        Nakanishi, W.; Shimada, Y.; Isobe, H. Structural fluctuation of disilanyl double-pillared bisheteroarenes, Chem. Asian J. 2013, 8 (6), 1177-1181.


(42)        Joy, S.; Nakanishi, W.; West, F. G. Hydroxylic additives enhance yield and scalability of silicon-directed Nazarov reaction, Tetrahedron Lett. 2013, 54(41), 5573-5576.


(43)        Nakanishi, W.; Matsuyama, N.; Hara, D.; Saeki, A.; Hitosugi, S.; Seki, S.;  Isobe, H. Disilanyl double-pillared bisternaphthyl (SiDPBT): Synthesis and interfused packing structures with herringbone and p-stack motifs. Chem.-Asian J., 2014, 9, 1782-1785.


(44)        Ishikawa, D.; Mori, T.; Yonamine, Y.; Nakanishi, W.; Cheung, D.; Hill, J.; Ariga, K. Mechanochemical Tuning of the Binaphthyl Conformation at the Air-Water Interface. Angew. Chem.-Int. Edit. 2015, 54(31) 8988-8991.


(45)        Minami, K.; Kasuya, Y.; Yamazaki, T.; Qingmin, J.; Nakanishi, W.; Hill, J. P.; Sakai, H.; Ariga, K. Highly Ordered 1D Fullerene Crystals for Concurrent Control of Macroscopic Cellular Orientation and Differentiation toward Large-Scale Tissue Engineering. Adv. Mater. 2015, 27(27) 4020-4026.


(46)        Venkata, K.; Kasuya, Y.; Qingmin, J.; Sathish, M.; Shrestha, L. K.; Ishihara, S.; Minami, K.; Morita, H.; Yamazaki, T.; Hanagata, N.; Miyazawa, K.; Acharya, S.; Nakanishi, W.; Hill, J. P.; Ariga, K. Vortex-Aligned Fullerene Nanowhiskers as a Scaffold for Orienting Cell Growth. ACS Appl. Mater. Interfaces 2015, 7(28), 15667-15673.


(47)        Yonamine, Y.*; Cervantes-Salguero, K.; Nakanishi, W.*; Kawamata, I.; Minami, K.; Komatsu, H.; Murata, S.; Hill, J. P.; Ariga, K. In situ 2D-extraction of DNA wheels by 3D through-solution transport. Phys. Chem. Chem. Phys. 2015, 17(48), 32122-32125.


(48)       Nien-Chi Huang, Qingmin Ji, Tomohiko Yamazaki, Waka Nakanishi, Nobutaka Hanagata, *Katsuhiko Ariga and *Shan-hui Hsu

“Gene transfer on inorganic/organic hybrid silica nanosheets”

Phys. Chem. Chem. Phys., 2015, 17(38), 25455-25462.


(49)        Y. Yonamine, K. Cervantes-Salguero, K. Minami, I. Kawamata, W. Nakanishi, J. Hill, S. Murata, K. Ariga : “Supramolecular 1-D polymerization of DNA origami through a dynamic process at the 2-Dimensionally confined air-water interface” Phys. Chem. Chem. Phys. 2016, 18(18), 12576-12581.


(50)        M. Tenjimbayashi, H. Komatsu, M. Akamatsu, W. Nakanishi, J. P. Hill, S. Shiratori*, K. Ariga : “Determination of blood potassium using a fouling-resistant PVDF-HFP- based optode” RSC Adv. 2016, 6(17), 14261-14265.

(51)        P. Bairi, K. Minami, W. Nakanishi, J. P. Hill, K. Ariga*, and L. K. Shrestha* "Hierarchically Structured Fullerene C-70 Cube for Sensing Volatile Aromatic Solvent Vapors "ACS Nano 2016, 10(7), 6631-6637.

(52)        P. Bairi, K. Minami, J. P. Hill, W. Nakanishi, L. K. Shrestha*, C. Liu, K. Harano, E. Nakamura, K. Ariga* “Supramolecular Differentiation for Construction of Anisotropic Fullerene Nanostructures by Time-Programmed Control of Interfacial Growth” ACS Nano 2016, 10(9), 8796-8802.

(53)        T. Mori, D. Ishikawa, Y. Yonamine, Y. Fujii, J. P. Hill, I. Ichinose, K. Ariga,* W. Nakanishi* “Mechanically Induced Opening-Closing Action of Binaphthyl Molecular Pliers: Digital Phase Transition vs. Continuous Conformational Change” ChemPhysChem 2017, 18(11), 1470-1474. (Special issue for mechanochemistry)




(1)          *Nakanishi, W. Hydrogen bonding-based molecular recognition by urea, thiourea and guanidine. J. Synth. Org. Chem., Jpn 2006, 64 (10), 1073-1074.

(2)          Nakanishi, W.; *West, F. G.; Advances in the Nazarov cyclization. Curr. Opin. Drug Discov. Devel. 2009, 12 (6), 732-751.

(3)          *Nakanishi, W.; Minami, K.; Shrestha, L. K.; Qingmin, J.; Hill, J. P.; *Ariga, K. Bioactive Nanocarbon Assemblies: Nanoarchitectonics and Applications Nano Today, 2014, 9(3), 378-394.

(4)          *Ariga, K.; Qingmin, J.; Nakanishi, W.; Hill, J. P. Thin Film Nanoarchitectonics. J. Inorg. Organomet. Polym. Mater., 2015, 25(3) 466-479.

(5)          *Ariga, K.; Qingmin, J.; Nakanishi, W.; Hill, J.; *Aono, M. Nanoarchitectonics: a new materials horizon for nanotechnology. Mater. Horiz., 2015, 2(4), 406-413.

(6)          中西和嘉 : “界面における分子・分子集合体の構造・機能制御” 超分子研究会アニュアルレビュー 2015[36] (2016) 2-3

(7)          Shirai, Y.; Minami, W.; Nakanishi, W.; Yonamine, Y.; Joachim, C.; *Ariga, K. Driving nanocars and nanomachines at interfaces: From concept of nanoarchitectonics to actual use in world wide race and hand operation. Jpn. J. Appli. Phys., 2016, 55, 1102A2.



[Invited lectures]

(1) 2011/8/23 : 中西和嘉“単結合多重連結による環状共役構造の構築”,第10 化学系薬学若手研究


(2) 2013/10/ : 中西和嘉“単結合多重連結による環状共役分子の合成と性質”,高分子学会茨城地区


(3) 2013/10/07-08 : 中西和嘉 : “非平面環状共役分子の合成と機能” 高分子学会茨城地区若手の会(仙台)

(4) 2014/07/18 : W. NAKANISHI : “Control of Structures and Properties of Non-planar Conjugated Molecules” MASA 2014 -The International Symposium on Material Architectonic (Tsukuba)

(5) 2014/08/06-07 : 中西和嘉 : “分子に力を.” 平成26年度スーパーサイエンスハイスクール生徒研究発表会(東京)

(6) 2014/10/14-16 : 中西和嘉 : “キャリアパスを選択する” 日本化学会秋季事業- 4CSJ化学フェスタ2014(船橋)

(7) 2014/10/20 : W. NAKANISHI : Bioactive nanocarbon assemblies: Nanoarchitectonics and applications 日仏先端科学シンポジウム(JFFoS)事前会議(東京)

(8) 2014/11/28-29 : 中西和嘉 : “非平面共役分子の動的解析に基づく組織化法の開発” 新学術領域研究「柔らかな分子系」 第 2 公開シンポジウム(大阪)

(9) 2015/01/23-25 : W. NAKANISHI : Bioactive nanocarbon assemblies: Nanoarchitectonics and applications 日仏先端科学シンポジウム(JFFoS)(京都)

(10) 2015/03/23 : 中西和嘉 : “セシウムの可視化とその応用への期待” グリーン・リノベーションを目指して 第一回(郡山)

(11) 2015/07/09-11 : W. NAKANISHI : Developments of Assembly of Nonplanar Conjugated Molecules Based on Dynamic Analysis 3 柔らかな分子系 公開シンポジウム(東京)

(12) 2016/06/27-28 : 中西和嘉 : “二次元界面での分子マシン制御” 超機能分子の創成 合成、計測、数理が織りなす社会実装分子の戦略的(岡崎)

(13) 2016/06/28 : 中西和嘉 : “界面での分子構造制御” 高分子材料設計化学セミナー(京都)

(14) 2017/03/16-19 : 中西和嘉 : Control of molecular machines at the interface 日本化学会第97春季年会(東京)

(15) 2017/04/18 : 中西和嘉 : “界面における分子マシン制御” 先端科学技術論 中央大学 (東京)







(1)          磯部 寛之,中西 和嘉,吉岡 知昭,Japan Patent Kokai 2012-121861 (28, June, 2012) 縮退系大環状化合物,並びに,その結晶及び製造方法




(1)          Nakanishi, W. In Superbases for Organic Synthesis: Related organocatalysts (2): Urea derivatives; Ishikawa, T. Ed.; Wiley, Chicester, 2009, 273-293.

(2)         中西和嘉炭素炭素結合の軌道と構造 化学と教育 2010, 58, (8), 366-369.

(3)          一杉俊平,中西和嘉,磯部寛之,最短カーボンナノチューブ分子を組上げる:帯状分子のボトムアップ化学合成 現代化学2012, 5月号,33-38.