原著論文
84. Rigid Nuclei and Flexible Nuclei: Appearance and Disappearance of Nuclei
in Indomethacin Glass Revealed by Long-Term Annealing Study
K. Kawakami, J. Phys. Chem. B 127, 5967-5977 (2023).
83. Nucleation during Storage Impeded Supersaturation in the Dissolution
Process of Amorphous Celecoxib
J. Song, K. Kawakami, Mol. Pharmaceutics 20, 4050-4057 (2023).
82. Ostwald Ripening of Triacylglycerol Droplets Embedded in Glass-Supported
Phospholipid Bilayers
C. Kataoka-Hamai, K. Kawakami, Langmuir 39, 10001-10010 (2023).
81. Crystallization of Amorphous Nifedipine under Isothermal Conditions:
Inter-laboratory Reproducibility and Investigation of the Factors Affecting
Reproducibility
T. Miyazaki, R. Mizoguchi, K. Ueda, T. Shinozaki, M. Kamoto, Y. Takeda,
S. Sakuma, N. Ito, M. Momo, K. Kawakami. J. Pharm. Sci. 112, 2703-2716 (2023).
80. Solubilization of Organic Liquid into Water Using Mesoporous Phospholipid
Particles
K. Kawakami, J. Tanaka, C. Kataoka-Hamai, Sust. Mater. Technol. 36, e00642 (2023).
79. Inhibition of Liquid-Liquid Phase Separation for Breaking the Solubility
Barrier of Amorphous Solid Dispersions to Improve Oral Absorption of Naftopidil
M. Fukiage, K. Suzuki, M. Matsuda, Y. Nishida, M. Oikawa, T. Fujita, K. Kawakami, Pharmaceutics 14, 2664 (2022).
78. Influence of the crystallization tendencies of pharmaceutical glasses on the applicability of the Adam-Gibbs-Vogel and Vogel-Tammann-Fulcher equations in the prediction of their long-term physical stability
K. Yamaguchi, R. Mizoguchi, K. Kawakami, T. Miyazaki, Int. J. Pharm. 626, 122158 (2022).
77. Hydrocarbon Penetration into Phospholipid Monolayers Formed at Hydrocarbon-Water
Interfaces
C. Kataoka-Hamai, K. Kawakami, Langmuir 38, 3720-3728 (2022).
76. Self-Organizing, Environmentally Stable, and Low-Cost Copper-Nickel
Complex Inks for Printed Flexible Electronics
W. Li, L. Li, F. Li, K. Kawakami, Q. Sun, T. Nakayama, X. Liu, M. Kanehara,
J. Zhang, T. Minari, ACS Appl. Mater. Interfaces 14, 8146-8156 (2022)
75. Determining the Dependence of Interfacial Tension on Molecular Area
for Phospholipid Monolayers Formed at Silicone Oil–Water and Tricaprylin–Water
Interfaces by Vesicle Fusion
C. Kataoka-Hamai, K. Kawakami, Langmuir 37, 7527-7535 (2021)
74. Stabilization mechanism of amorphous carbamazepine by transglycosylated
rutin, a non-polymeric amorphous additive with a high glass transition
temperature
C. Aoki, X. Ma, K. Higashi, Y. Ishizuka, K. Ueda, K. Kadota, K. Fukuzawa,
Y. Tozuka, K. Kawakami, E. Yonemochi, K. Moribe, Int. J. Pharm. 600, 120491
(2021).
73. Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution
in Oral Absorption of Albendazole from Amorphous Solid Dispersions
K. Suzuki, K. Kawakami, M. Fukiage, M. Oikawa, Y. Nishida, M. Matsuda,
T. Fujita, Pharmaceutics 13, 220 (2021).
72. Domain Sorting in Giant Unilamellar Vesicles Adsorbed on Glass
C. Kataoka-Hamai, K. Kawakami, Langmuir 37, 1082-1088 (2021).
71. Determination of the Coverage of Phosphatidylcholine Monolayers Formed
at Silicone Oil-Water Interfaces by Vesicle Fusion
C. Kataoka-Hamai, K. Kawakami, J. Phys. Chem. B 124, 8719-8727 (2020).
70. Importance of mesoporous silica particle size in the stabilization
of amorphous pharmaceuticals – the case of simvastatin
J. Knapik-Kowalczuk, D. Kramarczyk, K. Chmiel, J. Romanova, K. Kawakami, M. Paluch, Pharmaceutics 12, 384 (2020).
69. Impact of Degree of Supersaturation on the Dissolution and Oral Absorption
Behaviors of Griseofulvin Amorphous Solid Dispersions
K. Kawakami, K. Suzuki, M. Fukiage, M. Matsuda, Y. Nishida, M. Oikawa, T. Fujita,
J. Drug Delivery Sci. Technol. 56, 101172 (2020).
68. Correlation between drug dissolution and resistance to water-induced
phase separation in solid dispersion formulations revealed by solid-state
NMR spectroscopy
H. Okada, K. Ueda, Y. Yasuda, K. Higashi, M. Inoue, M. Ito, S. Noguchi,
K. Kawakami, K. Moribe, Int. J. Pharm. 577, 119086 (2020).
67. Geometrical Frustration of B-H Bonds in Layered Hydrogen Borides Accessible
by Soft Chemistry
S. Tominaka, R. Ishibiki, A. Fujino, K. Kawakami, K. Ohara, T. Masuda, I. Matsuda, H. Hosono, T. Kondo, Chem 6, 406-418
(2020).
66. Interaction Mechanism of Giant Unilasmellar Vesicles with Hydrophobic
Glass Surfaces and Silicone Oil-Water Interfaces: Adsorption, Deformation,
Rupture, Dynamic Shape Changes, Internal Vesicle Formation, and Desorption
C. Kataoka-Hamai, K. Kawakami, Langmuir 35, 16136-16145 (2019)
65. Ultraslow Cooling for the Stabilization of Pharmaceutical Glasses
K. Kawakami, J. Phys. Chem. B 123, 4996-5003 (2019).
64. Effect of drug–polymer interactions through HPMC-AS substituents on
the physical stability of solid dispersions studied by FTIR and solid-state
NMR
Y. Ishizuka, K. Ueda, H. Okada, J. Takeda, M. Karashima, K. Yazawa ,K.
Higashi, K. Kawakami, Y. Ikeda, K. Moribe, Mol. Pharmaceutics 16, 2785-2794 (2019).
63. Cryo-TEM and AFM Observation of the Time-dependent Evolution of Amorphous
Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid
Dispersions
Z. Zhao, H. Katai, K. Higashi, K. Ueda, K. Kawakami, K. Moribe, Mol. Pharmaceutics 16, 2184-2198 (2019).
62. Nucleation and Crystallization of Celecoxib Glass: Impact of Experience
of Low Temperature on Physical Stability
K. Kawakami, Thermochim. Acta 671, 43-47 (2019).
61. Phase Separation of Supersaturated Solution Created from Amorphous
Solid Dispersions: Relevance to Oral Absorption
K. Kawakami, K. Sato, M. Fukushima, A. Miyazaki, Y. Yamamura, S. Sakuma,
Eur. J. Pharm. Biopharm. 132, 146-156 (2018).
60. Mechanism of Enhanced Nifedipine Dissolution by Polymer-blended Solid
Dispersion through Molecular-level Characterization
K. Ueda, C. Yamazoe, K. Higashi, K. Kawakami, K. Moribe, Mol. Pharmaceutics 15, 4099-4109 (2018).
59. Time-dependent Phase Separation of Amorphous Solid Dispersions: Implications
for Accelerated Stability Studies
K. Kawakami, Y. Bi, Y. Yoshihashi, K. Sugano, K. Terada, J. Drug Delivery Sci. Technol.
46, 197-206 (2018).
58. Crystallization of Probucol from Solution and the Glassy State
K. Kawakami, C. Ohba, Int. J. Pharm. 517, 322-328 (2017).
57. Synergetic Role of Hypromellose and Methacrylic Acid Copolymer in the
Dissolution Improvement of Amorphous Solid Dispersions
N. Ohyagi, K. Ueda, K. Higashi, K. Yamamoto, K. Kawakami, K. Moribe, J. Pharm. Sci. 106, 1042-1050 (2017).
56. Physical Stabilization of Pharmaceutical Glasses Based on Hydrogen Bond Reorganization under Sub-Tg Temperature
S. Tominaka, K. Kawakami, M. Fukushima, A. Miyazaki, Mol. Pharmaceutics 14, 264-273 (2017).
55. Physicochemical Properties of Solid Phospholipid Particles as a Drug
Delivery Platform for Improving Oral Absorption of Poorly Soluble Drugs
K. Kawakami, A. Miyazaki, M. Fukushima, K. Sato, Y. Yamamura, K. Mohri, S. Sakuma,
Pharm. Res. 34, 208-216 (2017).
54. Dependence of Intestinal Absorption Profile of Insulin on Carrier Morphology
Composed of β-cyclodextrin-grafted Chitosan
Y. Daimon, N. Kamei, K. Kawakami, M. Takeda-Morishita, H. Izawa, Y. Takechi-Haraya, H. Saito, H. Sakai,
M. Abe, K. Ariga, Mol. Pharmaceutics 13, 4034–4042 (2016).
53. Enthalpy-driven Interactions with Sulfated Glycosaminoglycans Promote
Cell Membrane Penetration of Arginine Peptides
Y. Takechi-Haraya, R. Nadai, H. Kimura, K. Nishitsuji, K. Uchimura, K.
Sakai-Kato, K. Kawakami, A. Shigenaga, T. Kawakami, A. Otaka, H. Hojo, N. Sakashita, H. Saito,
Biochem. Biophys. Acta - Biomembranes 1858, 1339–1349 (2016).
52. General Understanding on Physical Stability of Pharmaceutical Glasses
K. Kawakami, T. Harada, M. Fukushima, Y. Yoshihashi, E. Yonemochi, K. Terada,
Asian J. Pharm. Sci. 11, 54-55 (2016).
51. Enhanced Boosting of Oral Absorption of Lopinavir through Electrospray
Co-encapsulation with Ritonavir
S. Sakuma, S. Matsumoto, N. Ishizuka, K. Mohri, M. Fukushima, C. Ohba,
K. Kawakami, J. Pharm. Sci. 104, 2977–2985 (2015).
50. Correlation between Glass Forming Ability and Fragility of Pharmaceutical
Compounds
K. Kawakami, T. Harada, Y. Yoshihashi, E. Yonemochi, K. Terada, H. Moriyama, J. Phys.
Chem. B 119, 4873–4880 (2015).
49. Totally Phospholipidic Mesoporous Particles
S. Zhang, K. Kawakami, L.K. Shrestha, G.C. Jayakumar, J.P. Hill, K. Ariga, J. Phys. Chem. C
119, 7255-7263 (2015).
48. A Molecular Complex Composed of β-cyclodextrin-grafted Chitosan and
pH-sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux
under Acidic pH
Y. Takechi-Haraya, K. Tanaka, K. Tsuji, Y. Asami, H. Izawa, A. Shigenaga,
A. Otaka, H. Saito, K. Kawakami, Bioconj. Chem. 26, 572-581 (2015).
47. Surface Effects on the Crystallization of Ritonavir Glass
K. Kawakami, J. Pharm. Sci. 104, 276-279 (2015).
46. Studies on the Physico-Chemical Characteristics of Collagen-Pectin
Composites
G. C. Jayakumar, N. Usharani, K. Kawakami, J. R. Rao, B. Unni Nair, RSC
Adv. 4, 63840-63849. (2014).
45. Preparation of Antibacterial Collagen-Pectin Particles for Biotherapeutics
G. C. Jayakumar, N. Usharani, K. Kawakami, J. R. Rao, B. Unni Nair, RSC Adv. 4, 42846-42854 (2014).
44. Reaction Mediated Artificial Cell Termination: Control of Vesicle Viability
Using Rh(I)-catalyzed Hydrogenation
H. Komatsu, Y. Daimon, K. Kawakami, M. Kanai, J.P. Hill, K. Ariga, Phys. Chem. Chem. Phys. 16, 16454-16457
(2014).
43. Relationship between Crystallization Tendencies during Cooling from
Melt and Isothermal Storage: Toward a General Understanding of Physical
Stability of Pharmaceutical Glasses
K. Kawakami, T. Harada, K. Miura, Y. Yoshihashi, E. Yonemochi, K. Terada, H. Moriyama,
Mol. Pharmaceutics 11, 1835-1843 (2014).
42．Fabrication of Solid Collagen Nanoparticles Using Electrospray Deposition
U. Nagarajan, K. Kawakami, S. Zhang, B. Chandrasekaran, B. Unni Nair, Chem. Pharm. Bull. 62, 422–428
(2014).
41. Low-density Microparticles with Petaloid Surface Structure for Pulmonary
Drug Delivery
K. Kawakami, Y. Hasegawa, S. Zhang, Y. Yoshihashi, E. Yonemochi, K. Terada, J. Pharm.
Sci. 103, 1309-1313 (2014).
40. Media-Dependent Morphology of Supramolecular Aggregates of β-Cyclodextrin-grafted
Chitosan and Insulin through Multivalent Interactions
Y. Daimon, H. Izawa, K. Kawakami, P. Żywicki, H. Sakai, M. Abe, J.P. Hill, K. Ariga, J. Mater. Chem. B
2, 1802-1812 (2014).
39. Studies on the Molecular Significance in the Interaction of Bilirubin
with Collagen
U. Nagarajan, J. G. Christopher, B. Chandrasekaran, R. R. Jonnalagadda,
U. N. Balachandran, K. Kawakami, Int. J. Biol. Macromol. 61, 404-410 (2013).
38. Nanoporous Carbon Sensor with Cage-in-Fibre Structure: Highly-Selective
Aniline Adsorbent towards Cancer Risk Management
Y. Kosaki, H. Izawa, S. Ishihara, K. Kawakami, M. Sumita, Y. Tateyama, Q. Ji, V. Krishnan, S. Hishita, Y. Yamauchi,
J. Hill, A. Vinu, S. Shiratori, K. Ariga, ACS Appl. Mater. Interfaces 5,
2930-2934 (2013).
37. Preparation of Fenofibrate Solid Dispersion Using Electrospray Deposition
and Improvement in Oral Absorption by Instantaneous Post-Annealing of the
Formulation
K. Kawakami, S. Zhang, R.S. Chauhan, N. Ishizuka, M. Yamamoto, Y. Masaoka, M. Kataoka,
S. Yamashita, S. Sakuma, Int. J. Pharm. 450, 123-128 (2013).
36. β-Cyclodextrin-crosslinked Alginate Gel for Patient-controlled Drug
Delivery Systems: Regulation of Host-guest Interactions with Mechanical
Stimuli
H. Izawa, K. Kawakami, M. Sumita, Y. Tateyama, J.P. Hill, K. Ariga, J. Mater. Chem. B 1, 2155-2161
(2013).
35. Practical Approach for Measuring Heat Capacity of Pharmaceutical Crystals/Glasses
by Modulated-Temperature DSC
T. Harada, K. Kawakami, Y. Yoshihashi, E. Yonemochi, K. Terada, H. Moriyama, Chem. Pharm. Bull.
61, 315-319 (2013).
34. Competition of Thermodynamic and Dynamic Factors during Formation of
Multi-Component Particles via Spray-Drying
K. Kawakami, Y. Hasegawa, K. Deguchi, S. Ohki, T. Shimizu, Y. Yoshihashi, E. Yonemochi,
K. Terada, J. Pharm. Sci. 102, 518–529 (2013).
33. Understanding the Glass-Forming Ability of Active Pharmaceutical Ingredients
for Designing Supersaturating Dosage Forms
K. Kawakami, T. Usui, M. Hattori, J. Pharm. Sci. 101, 3239-3248 (2012). (Editor's pick of 3rd quater)
32. Miscibility Analysis of Particulate Solid Dispersions Prepared by Electrospray
Deposition
K. Kawakami, Int. J. Pharm. 433, 71-78 (2012).
31. Dynamics of Ribavirin Glass in Sub-Tg Temperature Region
K. Kawakami, J. Phys. Chem. B 115, 11375-11381 (2011).
30. Coaxial Electrospray Formulations for Improving Oral Absorption of
a Poorly Water-Soluble Drug
S. Zhang, K. Kawakami, M. Yamamoto, Y. Masaoka, M. Kataoka, S. Yamashita, S. Sakuma, Mol. Pharmaceutics
8, 807-813 (2011).
29. エレクトロスプレー法を利用した難水溶性薬物のナノ粒子製剤化
川上亘作，張 紹玲，飯野京子, 粉体工学会誌 48, 167-172 (2011).
28. Parallel Thermal Analysis Technology Using an Infrared Camera for High-throughput Evaluation of Active Pharmaceutical Ingredients: A Case Study of Melting Point Determination
K. Kawakami, AAPS PharmSciTech 11, 1020-1205 (2010).
27. One-step Preparation of Chitosan Solid Nanoparticles by Electrospray
Deposition
S. Zhang, K. Kawakami, Int. J. Pharm. 397, 211-217 (2010).
26. Investigation of the Dynamic Process during Spray-drying to Improve
Aerodynamic Performance of Inhalation Particles
K. Kawakami, C. Sumitani, Y. Yoshihashi, E. Yonemochi, K. Terada, Int. J. Pharm. 390,
250-259 (2010).
25. Calorimetric Investigation of Solvent-Mediated Transformation of Sulfamerazine
Polymorphism
K. Kawakami, Y. Asami, I. Takenoshita, J. Pharm. Sci. 99, 76-81 (2010).
24. 経肺投与のための高分散性微粒子設計
川上亘作，住谷知弥，吉橋泰生，米持悦生，寺田勝英, 粉体工学会誌 46, 698-703 (2009).
23. Current Status of Amorphous Formulation and Other Special Dosage Forms as Formulations for Early Clinical Phases
K. Kawakami, J. Pharm. Sci. 98, 2875-2885 (2009).
22. 経肺投与を想定した噴霧乾燥微粒子の表面物性制御
川上亘作，住谷知弥，吉橋泰生，米持悦生，寺田勝英,第46回粉体に関する討論会講演論文集，97-100 （2008）.
21. 新規経肺投与デバイスへの適用を目指した微粒子設計
川上亘作，住谷知弥，内田義之，吉橋泰生，米持悦生，寺田勝英,第45回粉体に関する討論会講演論文集，63-67 （2007）
20. Impact of Surface Roughness on Tablet Appearance
R. Matsumoto,K. Kawakami, S. Aoki, Int. J. Pharm. 341, 44-49 (2007).
19. Reversibility of Enantiotropically-Related Polymorphic Transformations
from a Practical Viewpoint: Thermal Analysis of Kinetically Reversible/Irreversible
Polymorphic Transformations
K. Kawakami, J. Pharm. Sci. 96, 982-989 (2007).
18. Isothermal Crystallization of Imwitor 742 from Supercooled Liquid State
K. Kawakami, Pharm. Res. 24, 738-747 (2007).
17. Crystallization of Sucrose Glass under Ambient Conditions: Evaluation
of Crystallization Rate and Unusual Melting Behavior of Resultant Crystals.
K. Kawakami, K. Miyoshi, N. Tamura, T. Yamaguchi, Y. Ida, J. Pharm. Sci. 95, 1354-1363
(2006).
16. Solubilization Behavior of a Poorly Soluble Drug under Combined Use
of Surfactants and Cosolvents.
K. Kawakami, N. Oda, K. Miyoshi, T. Funaki, Y. Ida, Eur. J. Pharm. Sci. 28, 7-14 (2006).
15. Impact of Amount of Excess Solids on Apparent Solubility.
K. Kawakami, K. Miyoshi, Y. Ida, Pharm. Res. 22, 1537-1543 (2005).
14. Effect of Salt Type on Hygroscopicity of a New Cephalosporin S-3578.
K. Kawakami, Y. Ida, T. Yamaguchi, Pharm. Res. 22, 1365-1373 (2005).
13. Application of Modulated-Temperature DSC to the Analysis of Enantiotropically
Related Polymorphic Transitions.
K. Kawakami, Y. Ida, Thermochim Acta 427, 93-99 (2005).
12. Solubilization Behavior of Poorly Soluble Drugs with Combined Use of
Gelucire 44/14 and Cosolvent.
K. Kawakami, K. Miyoshi, Y. Ida, J. Pharm. Sci. 93, 1471-1479 (2004).
11. Direct Observation of the Enthalpy Relaxation and the Recovery Processes
of Maltose-Based Amorphous Formulation by Isothermal Microcalorimetry.
K. Kawakami, Y. Ida, Pharm. Res. 20, 1430-1436 (2003).
10. Microemulsion Formulation for Enhanced Absorption of Poorly Soluble
Drugs II. In vivo Study.
K. Kawakami, T. Yoshikawa, T. Hayashi, Y. Nishihara, K. Masuda, J. Control. Release 81, 75-82 (2002).
9. Microemulsion Formulation for Enhanced Absorption of Poorly Soluble
Drugs I. Prescription Design.
K. Kawakami, T. Yoshikawa, Y. Moroto, E. Kanaoka, K. Takahashi, Y. Nishihara, K. Masuda,
J. Control. Release 81, 65-74 (2002).
8. Assessment of Amorphous Content by Microcalorimetry.
K. Kawakami, T. Numa, Y. Ida, J. Pharm. Sci. 91, 417-423 (2002).
7. Effect of Hydrophilic Polymers on Physical Stability of Liposome Dispersions
K. Kawakami, Y. Nishihara, K. Hirano, J. Phys. Chem. B, 105, 2374-2385 (2001).
6. A Novel Method for Determining the Entrapped Volume of Liposomes
K. Kawakami, Y. Nishihara, K. Hirano, J. Liposome Res. 10, 236 (2000).
5. Liposome/Emulsion Transition Induced by α-Tocopheryl Acetate
K. Kawakami, Y. Nishihara, K. Hirano, Langmuir 15, 7454-7460 (1999).
4. Determination of the Entrapped Volume of Liposomes; Dilution Method
K. Kawakami, Y. Nishihara, K. Hirano, Anal. Biochem. 269, 139-142 (1999).
3. Rigidity of Lipid Membranes Detected by Capillary Electrophoresis
K. Kawakami, Y. Nishihara, K. Hirano, Langmuir 15, 1893-1895 (1999).
2. Compositional Homogeneity of Liposomal Membranes Investigated by Capillary
Electrophoresis
K. Kawakami, Y. Nishihara, K. Hirano, J. Colloid Interface Sci. 206, 177-180, (1998).
1. Mechanism of Protein Solubilization in Sodium Bis(2-ethylhexyl) Sulfosuccinate
Water-in-Oil Microemulsion
K. Kawakami, M. Harada, M. Adachi, A. Shioi, Colloids Surf. A 109, 217-233 (1996).