91Poster Award NomineeP5-21Anti-inflammatory Nanoparticles as Potential Treatment for Aortic Dissection Maria Thea Rane Clarin1,2,3, Eri Motoyama3, Ahmed Nabil2, Koichiro Uto2, Sachiko Kanki4, Kenichi Kimura3, Hiromi Yanagisawa3, and Mitsuhiro Ebara2 1 Ph.D. Program in Humanics, University of Tsukuba, 2 Research Center for Macromolecules and Biomaterials, National Institute for Materials Science (NIMS)3 Tsukuba Advanced Research Alliance (TARA) Center, University of Tsukuba, 4 Osaka Medical and Pharmaceutical University, Osaka Aortic dissection (AD) is characterized by the disruption of the aortic wall, which could be fatal as it might lead to rupture. More so, inflammation has been implicated in its development. Current treatments are still limited to surgery and anti-hypertensive agents. Thus, this research aims to develop nanoparticles that can be targeted in the aorta and suppress inflammation. Previously reported phosphatidyl serine-inspired polymeric particles (PSPs) known for modulating macrophages (MΦ) [1] were further validated using peritoneal MΦ. Lipopolysaccharide (LPS) was used to induce pro-inflammatory M1 MΦ. It has been observed that treatment with PSPs in LPS-induced MΦ reduces NF-kB signaling and significantly downregulates IL-6. This indicates its capacity to suppress inflammation. In our AD mouse model, we have observed the upregulation of vascular adhesion molecule-1, matrix metalloproteinases, and accumulation of M1 MΦ in the aortic lesions. These upregulated molecules will be further used in the design of targeting moiety for the modification of PSPs and its efficacy will be validated both in-vitro and in-vivo. [1] Nakagawa et. al., ACS Macro Lett., Vol. 11, Issue 2, 270–275 (2022). P5-22Rational Ligand Design for Enhanced Carrier Mobility in Self-powered SWIR Photodiodes Based on Colloidal InSb Quantum Dots Cong Zhang1,2, Subhashri Chatterjee1,2, and Naoto Shirahata1,2 1 Research Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS) 2 Graduate School of Chemical Sciences and Engineering, Hokkaido University Solution-processed colloidal III–V semiconductor quantum dot photodiodes (QPDs) have potential applications in short-wavelength infrared (SWIR) imaging due to their tunable spectral response range, possible multiple-exciton generation, operation at 0-V bias voltage and low-cost fabrication and are also expected to replace lead- and mercury-based counterparts that are hampered by reliance on restricted elements (RoHS). Our previous work successfully synthesized InSb quantum dots (QDs) via a solution-based method and utilized these QDs to fabricate SWIR detection diodes. However, similar to other studies, our devices exhibited significant limitations such as excessive dark current and prolonged detection times, attributed to the high surface defect density of the QDs, which diminished their practical application potential. In this study, we employed ligand exchange, utilizing sulfur ion oleylamine ligands to reduce the In2O3 oxide defects on the surface of the InSb QDs. This modification led to an enhanced photodetection response speed (rise time of 0.1s) and significantly reduced the dark current (as low as nA/cm²). Additionally, the reduced interdot spacing improved the carrier mobility within the QD layer of the device. As a result, the external quantum efficiency (EQE) of the ligand-modified device increased to 18.5%, thereby enhancing the potential of InSb QDs for infrared imaging sensor. [1] S. Chatterjee, Nanoscale Horiz., 9, 817-827 (2024).
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