Yukio Nagasaki
- Affiliation:
-
- MANA Satellite, NIMS
- Department of Materials Science, Graduate School of Pure and Applied Science, University of Tsukuba
- Master's School of Medical Sciences, University of Tsukuba
- Tsukuba Research Center for Interdisciplinary Materials Science (TIMS)
- Strategic Initiatives for Interdisciplinary Materials Science (SI-IMS)
- Polyscale Technology Center, Research Institute for Science and Technology, Tokyo University of Science
- Specialty:
- Biomaterials and Polymer Chemistry
- Academic degree:
- Ph.D. Tokyo University of Science (1986)
- Home Page:
Educational & Working History
| 2009 | - | Present | Council Member, The Society of Polymer Science, Japan |
| 2009 | Board Member, Committee of Strategy and Planning of Next Generation of Nanotechnology in Japan, MEXT | ||
| 2008 | - | Present | Council Member, The Chemical Society of Japan, Kanto Division |
| 2008 | Professor, Strategic Initiative for Interdisciplinary Materials Science, University of Tsukuba | ||
| 2007 | - | Present | Advisory Board, Reactive Polymer, Elsevier |
| 2007 | Principal Investigator, Satellite Laboratory, MANA, NIMS | ||
| 2006 | - | Present | Adjunct Professor, Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan |
| 2006 | Honorary Professor, Polyscale Technology Center, Tokyo University of Science, Japan | ||
| 2006 | - | Present | Project Reader, Nagasaki Project, Nanology Aspect, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan |
| 2004 | Professor, Tsukuba Research Center for Interdisciplinary Materials Science, University of Tsukuba, Japan | ||
| 2004 | Professor, Graduate School of Pure and Applied Science, University of Tsukuba | ||
| 2003 | Professor, Faculty of Industrial Science and Technology, Tokyo University of Science | ||
| 1999 | Associate Professor, Faculty of Industrial Science and Technology,Tokyo University of Science | ||
| 1994 | Assistant Professor, Faculty of Industrial Science and Technology, Tokyo University of Science | ||
| 1989 | Research Associate, Faculty of Industrial Science and Technology, Tokyo University of Science | ||
| 1987 | Research Associate, Faculty of Engineering, Tokyo University of Science | ||
| 1987 | Ph.D. Dept. Industrial Chemistry, Graduate School of Engineering, Tokyo University of Science |
Research History
Yukio Nagasaki's research interest covers creation of new functionality materials via novel polymerization technique. End-functionalized poly(ethylene glycol)s as a surface modification agent and novel nanoparticles as intelligent drug vehicle are his main target for new materials design. He is also interested in creation of high performance biointerface, including non-fouling and specific bio-recognition characters. He found that poly(ethylene glycol) tethered chain surface having a mixture of long and short chain lengths reduces non-specific protein adsorption almost completely (Uchida, et al., Ana. Chem., 77(4): 1075-1080, 2005). Antibody/PEG co-immobilized surface increased reactivity of the surface antibody with the increasing PEG tethered chain density (Nagasaki, et al., J. Coll. Int. Sci., 309(2), 524-530, 2007). This immunochemical enhancing effect is promising phenomena for creation of a high functionality surface of versatile biomaterials. Recently, we started to design novel nanomedicine, which reduce oxidative stress effectively toward ischemia reperfusion injury. It is also utilized visualization of for oxidative stress in vivo.
Selected Papers
- Inverted Pattern Formation of Cell Microarrays on Poly(ethylen glycol) (PEG) Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains
- Yoshimoto K, Ichino M, Nagasaki Y
- Lab Chip, 2009; 9: 1286-1289.
- Regulation of Lysozyme Activity Based on Thermotolerant Protein/Smart Polymer Complex Formation
- Ganguli S, Yoshimoto K, Tomita S, Sakuma H, Matsuoka T, Shiraki K, Nagasak Y
- J Am Chem Soc, 2009; 131(18): 6549-6553.
- Design of Core-shell-type Nanoparticles Carrying Stable Radicals in the Core
- Yoshitomi T, Miyamoto D, Nagasaki Y
- Biomacromolecules, 2009; 10(3): 596-601.
- High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface: High Sensitive Ferritin Immunodiagnostics
- Yuan X, Yoshimoto K, Nagasaki Y
- Anal Chem, 2009; 81(4): 1549-1556.
- A Smart Nanoprobe Based on Fluorescence-Quenching PEGylated Nanogel Containing Gold Nanoparticles for Monitoring the Cancer Response to Therapy
- Oishi M, Tamura A, Nakamura T, Nagasaki Y
- Adv Funct Mater, 2009; 19(6): 827-834.
- Binding Enhancement of Antigen-Functionalized PEGylated Gold Nanoparticles onto Antibody-Immobilized Surface by Increasing the Functionalized Antigen using α-sulfanyl-ω-amino-PEG
- Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y
- Chem Commun, 2008; 2008: 5369-5371.
- Design of poly(ethylene glycol)/streptavidin co-immobilized upconversion nanophosphors and their application to fluorescence biolabeling
- Kamimura M, Miyamoto D, Saito Y, Soga K, Nagasaki Y
- Langmuir, 2008; 24(16): 8864-8870.
- PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy
- Nagasaki Y
- Chem Lett, 2008; 37(6): 564-569.
- pH-Responsive PEGylated nanogels as targetable and low invasive endosomolytic agents to induce the enhanced transfection efficiency of nonviral gene vectors
- Oishi M, Hayashi H, Itaka K, Kataoka K, Nagasaki Y
- Colloid Polym Sci, 2007; 285(9): 1055-1060.
- Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels-Nanogel composed of poly [2-(N, N-diethylamino) ethyl methacrylate] core and PEG tethered chains
- Oishi M, Nagasaki Y
- React Funct Polym, 2007; 67(11): 1311-1329.