Educational & Working History

2009 - Present Council Member, The Society of Polymer Science, Japan
2009 Board Member, Committee of Strategy and Planning of Next Generation of Nanotechnology in Japan, MEXT
2008 - Present Council Member, The Chemical Society of Japan, Kanto Division
2008 Professor, Strategic Initiative for Interdisciplinary Materials Science, University of Tsukuba
2007 - Present Advisory Board, Reactive Polymer, Elsevier
2007 Principal Investigator, Satellite Laboratory, MANA, NIMS
2006 - Present Adjunct Professor, Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
2006 Honorary Professor, Polyscale Technology Center, Tokyo University of Science, Japan
2006 - Present Project Reader, Nagasaki Project, Nanology Aspect, Tsukuba Advanced Research Alliance, University of Tsukuba, Japan
2004 Professor, Tsukuba Research Center for Interdisciplinary Materials Science, University of Tsukuba, Japan
2004 Professor, Graduate School of Pure and Applied Science, University of Tsukuba
2003 Professor, Faculty of Industrial Science and Technology, Tokyo University of Science
1999 Associate Professor, Faculty of Industrial Science and Technology,Tokyo University of Science
1994 Assistant Professor, Faculty of Industrial Science and Technology, Tokyo University of Science
1989 Research Associate, Faculty of Industrial Science and Technology, Tokyo University of Science
1987 Research Associate, Faculty of Engineering, Tokyo University of Science
1987 Ph.D. Dept. Industrial Chemistry, Graduate School of Engineering, Tokyo University of Science

Research History

Yukio Nagasaki's research interest covers creation of new functionality materials via novel polymerization technique. End-functionalized poly(ethylene glycol)s as a surface modification agent and novel nanoparticles as intelligent drug vehicle are his main target for new materials design. He is also interested in creation of high performance biointerface, including non-fouling and specific bio-recognition characters. He found that poly(ethylene glycol) tethered chain surface having a mixture of long and short chain lengths reduces non-specific protein adsorption almost completely (Uchida, et al., Ana. Chem., 77(4): 1075-1080, 2005). Antibody/PEG co-immobilized surface increased reactivity of the surface antibody with the increasing PEG tethered chain density (Nagasaki, et al., J. Coll. Int. Sci., 309(2), 524-530, 2007). This immunochemical enhancing effect is promising phenomena for creation of a high functionality surface of versatile biomaterials. Recently, we started to design novel nanomedicine, which reduce oxidative stress effectively toward ischemia reperfusion injury. It is also utilized visualization of for oxidative stress in vivo.

Selected Papers

  1. Inverted Pattern Formation of Cell Microarrays on Poly(ethylen glycol) (PEG) Gel Patterned Surface and Construction of Hepatocyte Spheroids on Unmodified PEG Gel Microdomains
    Yoshimoto K, Ichino M, Nagasaki Y
    Lab Chip, 2009; 9: 1286-1289.
  2. Regulation of Lysozyme Activity Based on Thermotolerant Protein/Smart Polymer Complex Formation
    Ganguli S, Yoshimoto K, Tomita S, Sakuma H, Matsuoka T, Shiraki K, Nagasak Y
    J Am Chem Soc, 2009; 131(18): 6549-6553.
  3. Design of Core-shell-type Nanoparticles Carrying Stable Radicals in the Core
    Yoshitomi T, Miyamoto D, Nagasaki Y
    Biomacromolecules, 2009; 10(3): 596-601.
  4. High-performance Immunolatex Possessing A Mixed-PEG/Antibody Co-immobilized Surface: High Sensitive Ferritin Immunodiagnostics
    Yuan X, Yoshimoto K, Nagasaki Y
    Anal Chem, 2009; 81(4): 1549-1556.
  5. A Smart Nanoprobe Based on Fluorescence-Quenching PEGylated Nanogel Containing Gold Nanoparticles for Monitoring the Cancer Response to Therapy
    Oishi M, Tamura A, Nakamura T, Nagasaki Y
    Adv Funct Mater, 2009; 19(6): 827-834.
  6. Binding Enhancement of Antigen-Functionalized PEGylated Gold Nanoparticles onto Antibody-Immobilized Surface by Increasing the Functionalized Antigen using α-sulfanyl-ω-amino-PEG
    Yoshimoto K, Hoshino Y, Ishii T, Nagasaki Y
    Chem Commun, 2008; 2008: 5369-5371.
  7. Design of poly(ethylene glycol)/streptavidin co-immobilized upconversion nanophosphors and their application to fluorescence biolabeling
    Kamimura M, Miyamoto D, Saito Y, Soga K, Nagasaki Y
    Langmuir, 2008; 24(16): 8864-8870.
  8. PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy
    Nagasaki Y
    Chem Lett, 2008; 37(6): 564-569.
  9. pH-Responsive PEGylated nanogels as targetable and low invasive endosomolytic agents to induce the enhanced transfection efficiency of nonviral gene vectors
    Oishi M, Hayashi H, Itaka K, Kataoka K, Nagasaki Y
    Colloid Polym Sci, 2007; 285(9): 1055-1060.
  10. Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels-Nanogel composed of poly [2-(N, N-diethylamino) ethyl methacrylate] core and PEG tethered chains
    Oishi M, Nagasaki Y
    React Funct Polym, 2007; 67(11): 1311-1329.