Tissue adhesive for biomedical applications

He developed novel tissue adhesives consisting of organic acid-based crosslinker and biodegradable polymers for bonding soft tissues. The bonding strength of the developed adhesive was from 3 to 6-fold higher than that of commercially-available adhesive. He also clarified that the developed adhesive showed excellent biocompatibility, bioabsorbability and only mild tissue reaction in rat subcutaneous tissue. He is now applying this adhesive for various clinical fields collaborating with medical institutes.

Amphiphilic polymers for promoting cell aggregates

He developed a polymeric crosslinker for promoting cellular spheroid. His approach was based on the crosslinking of cell membrane using a polymeric crosslinker via hydrophobic interaction. Formation of spheroids was achieved when the polymeric crosslinker was added to the suspension of rat pancreatic β-cell line RIN especially in the absence of serum. He also found that biological functions such as insulin secretion or E-cadherin mRNA expression of the resulting spheroids were remarkably enhanced by the addition of the polymeric crosslinker.