Tetsushi Taguchi

Tetsushi Taguchi
Biomaterials Unit, Smart Biomaterials Group
Academic degree:
Ph.D., Kagoshima University
Recent publications
See NIMS Researchers DB

Educational and Working History

2011 - Present MANA Scientist, Smart Biomaterials Group, MANA, NIMS
2007 - Present Associate Professor, University of Tsukuba
2007 - Present Senior Researcher, National Institute for Materials Science
2003 - 2006 Researcher, National Institute for Materials Science
2001 - 2002 CREST-JST Researcher, National Institute in Inorganic Materials
2000 PosDoc, National Institute for Advanced Interdisciplinary Research
1999 Ph.D., Kagoshima University

Research Interests

Tissue adhesive for biomedical applications

He developed novel tissue adhesives consisting of organic acid-based crosslinker and biodegradable polymers for bonding soft tissues. The bonding strength of the developed adhesive was from 3 to 6-fold higher than that of commercially-available adhesive. He also clarified that the developed adhesive showed excellent biocompatibility, bioabsorbability and only mild tissue reaction in rat subcutaneous tissue. He is now applying this adhesive for various clinical fields collaborating with medical institutes.

Amphiphilic polymers for promoting cell aggregates

He developed a polymeric crosslinker for promoting cellular spheroid. His approach was based on the crosslinking of cell membrane using a polymeric crosslinker via hydrophobic interaction. Formation of spheroids was achieved when the polymeric crosslinker was added to the suspension of rat pancreatic β-cell line RIN especially in the absence of serum. He also found that biological functions such as insulin secretion or E-cadherin mRNA expression of the resulting spheroids were remarkably enhanced by the addition of the polymeric crosslinker.

Selected Papers

  1. Enhanced insulin secretion of physically crosslinked pancreatic β-cells by using a poly(ethylene glycol) derivative with oleyl groups
    M. Ito and T. Taguchi
    Acta Biomaterial, 2009, 5, 2945-2953.

  2. Biodegradable adhesives composed of human serum albumin and organic acid-based crosslinkers with active ester groups
    T. Taguchi, H. Saito, M. Iwasashi, M. Sakane and N. Ochia
    J. Bioact. Compat. Polym., 2009, 24, 546-559.

  3. In vivo evaluation of bonding ability and biocompatibility of a novel biodegradable glue consisting of tartaric acid derivative and human serum albumin
    M. Iwasashi, M. Sakane, H. Saito, T. Taguchi, T. Tateishi and N. Ochiai
    J. Biomed. Mater. Res., 2009, 90A, 543-548.

  4. Development of a novel glue consisting of naturally-derived biomolecules: citric acid and human serum albumin
    T. Taguchi, H. Saito, M. Iwasashi, M. Sakane, S. Kakinoki, N. Ochiai and J. Tanaka
    J. Nanosci. Nanotechnol., 2007, 7, 742-747.

  5. Unusual cell adhesion and antithrombogenic behavior of citric acid-cross-linked collagen matrices
    5. H. Saito, S. Murabayashi, Y. Mitamura and T. Taguchi
    Biomacromolecules, 2007, 8, 1992 -1998.

  6. Development of Biocompatible Glue for Minimum Invasive Therapy
    T. Taguchi, H. Saito, M. Iwasashi, M. Sakane, S. Kakinoki, N. Ochiai and T. Tateishi
    Key. Eng. Mater., 2007, 330-332, 1339-1342.

  7. Biocompatible high-strength glue consisting of citric acid derivative and collagen
    T. Taguchi, H. Saito, H. Aoki, H. Kobayashi and J. Tanaka
    Mater. Sci. Eng. C, 2006, 26, 9-13.

  8. Encapsulation of chondrocytes in injectable alkali-treated collagen gels prepared using poly(ethylene glycol)-based 4-armed star polymer
    T. Taguchi, L. Xu, H. Kobayashi, A. Taniguchi, K. Kataoka and J. Tanaka
    Biomaterials, 2005, 26, 1247-1252.