Mitsuhiro Ebara

Mitsuhiro Ebara
Biomaterials Unit, Smart Biomaterials Group
Smart Biomaterials
Academic degree:
Ph.D. Waseda University (2004)
Recent publications
See NIMS Researchers DB

Educational and Working History

2010 - Present MANA Scientist, MANA, NIMS
2009 - Present Senior Researcher, Biomaterials Center, NIMS
2007 Assistant Professor, Medical Center for Translational Research, Osaka University Hospital
2004 Post Doctoral Researcher, Department of Engineering, University of Washington (USA)

Research History

He received his Ph.D. in Chemical Engineering at Department of Applied Chemistry at Waseda University in 2004. During his doctoral studies, he initiated his studies on design of smart polymer-grafted surfaces for cell sheet engineering in the laboratory of Prof. Kiyotaka Sakai (collaboration with Prof. Teruo Okano, Tokyo Women's Medical University). He moved to the Bioengineering Department at University of Washington, Seattle, USA, for a post-doctoral training period during 2004-2006. During this time, he applied the smart polymer technologies for rapid developing diagnostics in the laboratory of Prof. Allan S. Hoffman and Prof. Patrick S. Stayton. He pursued this line of research after returning to Japan in 2007, when he became an Assistant Professor at Medical Center for Translational Research at Osaka University Hospital. In 2009, he moved to National Institute for Materials Science (NIMS) as the senior researcher. His major field involves molecular design of novel smart polymers (stimuli-responsive polymers) for biomedical applications, such as regenerative medicine, drug delivery, and rapid diagnostics etc. His future research projects will specifically explore smart material technologies that contribute to human health in 21st century.


  • Young Scientist Lecture Award, 54th Symposium on macromolecules, The Society of Polymer Science, Japan, Jul., 2007
  • Poster Award for the Outstanding Presentation (ISSP International Workshop 5th Gel Symposium), Nov., 2003
  • 17th "Advanced-tech grand prize that opens originality", student section by Minister of Education, Culture, Sports, Science and Technology (MEXT), Jul., 2003
  • Excellent poster prize, Division of Biochemical Engineering, The Society of Chemical Engineer Japan, The 36th Fall Meeting Sep., 2003
  • Student lecture prize, The Chemical Society of Japan, The 83rd Spring Meeting, Mar., 2003
  • Japan-Korea Joint Symposium Award (24th Annual Meeting of the Japanese Society for Biomaterials), Oct., 2002
  • Azusa Ono Memorial Awards for Academic Studies, Mar., 2002
  • Korea-Japan Biomaterials Research Young Investigator's Award (Fall Meeting of the Korean Society for Biomaterial), Sep., 2001

Selected Papers

  1. PS Protein-polymer conjugate capture, enrichment and release in "smart" microchannels
  2. Hoffman JM, Ebara M, Lai JJ, Folch A, Hoffman AS, Stayton PS
    Lab on a Chip, in press.
  3. A novel approach to observing synergy effects of PHSRN on integrin-RGD binding using intelligent surfaces
  4. Ebara M, Yamato M, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Advanced Materials, 2008; 20: 3034-3038
  5. The effect of extensible PEG tethers on shielding between grafted thermo- responsive polymer chains and integrin?RGD binding
  6. Ebara M, Yamato M, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Biomaterials, 2008; 29: 3650-3655
  7. Surface modification of microfluidic channels by UV-mediated graft polymerization of non-fouling and 'smart' polymers
  8. Ebara M, Hoffman JM, Stayton PS, Hoffman AS
    Radiation Physics and Chemistry, 2007; 76: 1409-1413
  9. Dual magnetic-/temperature-responsive nanoparticles for microfluidic separations and assays
  10. Lai JJ, Hoffman JM, Ebara M, Hoffman AS, Estournes C, Wattiaux A, Stayton PS
    Langmuir, 2007; 23: 7385-7391
  11. Switchable surface traps for injectable bead-based chromatography in PDMS microfluidic channels
  12. Ebara M, Hoffman, JM, Hoffman AS, Stayton PS
    Lab on a Chip, 2006; 6: 843-848
  13. Temperature-responsive cell culture surfaces enable on-off" affinity control between cell integrins and RGDS ligands
  14. Ebara M, Yamato M, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Biomacromolecules, 2004; 5: 505-510
  15. Immobilization of cell adhesive peptides to temperature-responsive surfaces facilitates both serum-free cell adhesion and non-invasive cell harvest
  16. Ebara M, Yamato M, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Tissue Engineering, 2004; 10: 1125-1135
  17. Incorporation of new carboxylate functionalized co-monomer to temperature-responsive polymer-grafted cell culture surfaces
  18. Ebara M, Yamato M, Nagai S, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Surface Science, 2004; 570: 134-141
  19. Copolymerization of 2-carboxyisopropylacrylamide with N-isopropylacrylamide accelerates cell detachment from grafted surfaces by reducing temperature
    Ebara M, Yamato M, Hirose M, Aoyagi T, Kikuchi A, Sakai K, Okano T
    Biomacromolecules, 2003; 4: 344-349