Kohsaku Kawakami
- Affiliation:
- Smart Biomaterials Group
- Specialty:
- Pharmaceutical Materials Science
- Academic degree:
- Ph.D., Kyoto University (2000)
- Recent publications
- See NIMS Researchers DB
- Home Page:
- See Personal Page (in japanese)
Educational and Working History
| 2011 | - | Present | MANA Scientist, Smart Biomaterials Group, MANA, NIMS |
| 2008 | - | 2010 | MANA Scientist, NanoBio Devices Group, MANA, NIMS |
| 2006 | - | Present | Senior Researcher, Biomaterials Center, NIMS |
| 2005 | - | 2006 | Banyu Pharmaceutical Co. (Affiliate of Merck & Co.)., Senior Researcher |
| 2001 | - | 2002 | University of Connecticut, School of Pharmacy, Visiting Scholar |
| 1994 | - | 2005 | Shionogi & Co., Ltd., Researcher/Senior Researcher |
| 1992 | Institute for Chemical Engineering, University of Dortmund, Germany | ||
| 1992 | - | 1994 | Graduate School of Engineering, Kyoto University, Japan (M.S.) |
| 1988 | - | 1992 | Faculty of Engineering, Kyoto University, Japan (B.S.) |
Research Interests
Fabrication of fine particles for oral/pulmonary drug delivery and development of inhalation devices
He is designing nano/micron-sized particles for efficient oral/pulmonary drug delivery via bottom-up process including spray-dry and electrospray methods. Efficient pulmonary drug delivery can be achieved only with good inhalation devices, which is of his interest as well.
Control of molecular state of organic crystals/glasses and development of their assessment technologies
Crystal forms need to be controlled precisely for the manufacture of pharmaceutical products. He is controlling the crystal forms of drug substances from thermodynamic and kinetic viewpoints. Molecular mobility and miscibility of glassy components are controlled as well to obtain desired macroscopic characteristics.
Application of colloidal carriers for drug delivery system
He has developed various colloidal carriers for drug delivery systems including liposomes and microemulsions. Improvement of their functions and elucidation of their action mechanism in vivo are being conducted.
Selected Papers
- Parallel Thermal Analysis Technology Using an Infrared Camera for High-throughput Evaluation of Active Pharmaceutical Ingredients: A Case Study of Melting Point Determination
- K. Kawakami
- AAPS PharmSciTech, in press.
- One-step Preparation of Chitosan Solid Nanoparticles by Electrospray Deposition
- S. Zhang, K. Kawakami
- Int. J. Pharm. 397, 211-217 (2010).
- Investigation of the Dynamic Process during Spray-drying to Improve Aerodynamic Performance of Inhalation Particles
- K. Kawakami, C. Sumitani, Y. Yoshihashi, E. Yonemochi, K. Terada
- Int. J. Pharm. 390, 250-259 (2010).
- Calorimetric Investigation of Solvent-Mediated Transformation of Sulfamerazine Polymorphism
- K. Kawakami, Y. Asami, I. Takenoshita
- J. Pharm. Sci. 99, 76-81 (2010).
- Current Status of Amorphous Formulation and Other Special Dosage Forms as Formulations for Early Clinical Phases
- K. Kawakami
- J. Pharm. Sci. 98, 2875-2885 (2009).
- Reversibility of Enantiotropically-Related Polymorphic Transformations from a Practical Viewpoint: Thermal Analysis of Kinetically Reversible/Irreversible Polymorphic Transformations
- K. Kawakami
- J. Pharm. Sci. 96, 982-989 (2007).
- Isothermal Crystallization of Imwitor 742 from Supercooled Liquid State
- K. Kawakami
- Pharm. Res. 24, 738-747 (2007).
- Calorimetric Investigation of the Structural Relaxation of Amorphous Materials: Evaluating Validity of the Methodologies
- K. Kawakami, M. J. Pikal
- J. Pharm. Sci. 94, 948-965 (2005).
- Microemulsion Formulation for Enhanced Absorption of Poorly Soluble Drugs I. Prescription Design
- K. Kawakami, T. Yoshikawa, Y. Moroto, E. Kanaoka, K. Takahashi, Y. Nishihara, K. Masuda
- J. Control. Release 81, 65-74 (2002).
- Microemulsion Formulation for Enhanced Absorption of Poorly Soluble Drugs II. In vivo Study.
- K. Kawakami, T. Yoshikawa, T. Hayashi, Y. Nishihara, K. Masuda
- J. Control. Release 81, 75-82 (2002).