Masanori Kikuchi

Kikuchi Masanori
Affiliation:
Biomaterials Unit, Bioceramics Group
Specialty:
Ceramics-based biomaterials (Calcium phosphate ceramics and their composites with natural and synthetic organic polymers)
Academic degree:
Ph. D., Waseda University (1995)
Recent publications
See NIMS Researchers DB
 

Educational and Working History

2011 - Present MANA Scientist, Group Leader, Bioceramicss Group, MANA, NIMS
2011 - Present Visiting Professor, Hokkaido University Graduate Shool of Information Science and Technology
2007 - 2010 Group Leader, Biomaterials Center, NIMS
2006 - 2007 Affiliated Fellow (Part-time), Science and Technology Foresight Center (Nanotechnology and Materials Research Unit)
2003 - 2006 Senior Researcher, Biomaterials Center, NIMS
2002 - 2004 Research Fellow, Harvard Medical School
2001 - 2003 Researcher, Biomaterials Center, NIMS
1997 - 2001 Researcher, National Institute for Research in Inorganic Materials
1995 - 1998 Visiting Researcher, Advanced Research Center for Science and Engineering, Waseda University
1995 - 1997 Postdoctoral Fellow, National Institute for Research in Inorganic Materials

Research Interests

Bioactive ceramics materials

"Bioactive" in ceramics material field means direct bone bonding property. The bioactivity is usually found in calcium phosphate ceramics and silica-based glass and glass ceramics. I am very interested in calcium phosphate ceramics and work on enhancement of biological functionalities of these ceramics.

Composite biomaterials of ceramics and polymers

Hard tissues in human body, bones and teeth, are mainly composed of collagen and apatite nanocrystals. Accordingly, learning and mimicking of formation process of hard tissues are quite important to prepare biomaterials with extremely high biological functionalities such as rapid and assured tissue regeneration.

Awards

  • 2005. 1. Top 1% cited paper in the field (45 times cited), Masanori Kikuchi, Self-Organization Mechanism in a Bone-like Hydroxyapatite / Collagen Nanocomposite Synthesized in vitro and Its Biological Reaction in vivo, Biomaterials, 22, 1705-1711 (2001), Thomson Web of Science.
  • 2004.11. Young Investigator Award, Fabrication of porous body using HAp/Col nanocomposite and its biological reaction, Korea-Japan International Seminar on Ceramics
  • 2000. 4. Ichimura Academic Award, "Creation of Organic/Inorganic composite using Self-Organization Process. - Development of Tissue Inductive Material -", The New Technology Development Foundation, Japan
  • 2001. 5. 55th Award of The Ceramic Society of Japan, "Research on the Composite for Guided Bone Regeneration Membrane with controlled Interaction between the Inorganic/Organic Interfaces", Ceramic Society of Japan
  • 2000. 3. Takagi Award for Good Presentation, "The Biomimetic Synthesis of Hydroxyapatite/Collagen Nanocomposites with Bone-Related Cell Inductive Property.", Intelligent Material Forum, Japan
  • 1999. 5. Award for Good Achievement, "Research on development of Self-Organized Organic/Inorganic Composite using Interaction between Materials Surface.", Science and Technology Agency, Japan

Selected Papers

  1. Particline Effect of Canine Allogenic Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Mixed With Beta Tricalcium Phosphate on Bone Regeneration in Ectopic Implantations
    Y. E. Byeon, H. H. Ryu, Y. Koyama, M. Kikuchi, W. E. Kim, K. S. Kang and O. Kweon
    Cytotherapy, 2010, 12, 626-636.
  2. Repair of Large Osteochondral Defects in Rabbits Using Porous Hydroxyapatite/Collagen (hap/Col) And Fibroblast Growth Factor-2 (fgf-2)
    H. Maehara, T. Yoshii, I. Torigoe, Y. Kawasaki, Y. Sugata, M. Yuasa, M. Hirano, N. Mochizuki, M. Kikuchi, K. Shinomiya and A. Okawa
    Journal of Orthopaedic Research, 2010, 28 (5), 677-686.

  3. Osteogenic Activity of MG63 Cells on Bone-Like Hydroxyapatite/Collagen Nanocomposite Sponges
    T. Yoshida, M. Kikuchi, Y .Koyama and K. Takakuda
    Journal of Materials Science: Materials in Medicine, 2010, 21 (4), 1263?1272.
  4. Comparison of Canine Allogenic Umbilical Cord Blood Derived Mesenchymal Stem Cells And Their Lysates Mixed With Beta-Tricalcium Phosphate in Orthotopic Implantation
    Y. E. Byeon, H. H. Ryu, S. S. Park, Y. Koyama, M. Kikuchi, M. S. Seo,W. H. Kim Wan, K. S. Kang and O. K. Kweon

    Journal of Tissue Engineering And Regenerative Medicine, 2009, 6 [4-11], 833-839.

  5. Effects of Pore Size And Implant Volume of Porous Hydroxyapatite/Collagen (hap/Col) on Bone Formation in A Rabbit Bone Defect Model
    Tsuchiya, A., Sotome, S., Asou, Y., Kikuchi, M., Koyama, Y., Ogawa, T., Tanaka, J. and Shinomiya, K.
    Journal of Medical And Dental Sciences, 2008, 55(1), 91-99.
  6. Implantation of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells Mixed With Beta-Tricalcium Phosphate Enhances Osteogenesis in Bone Defect Model Dog
    Byung-Jun Jang, Ye-Eun Byeon, Ji-Hey LIm, Hak-Hyun Ryu, Wan Hee Kim, Yoshihisa Koyama, Masanori Kikuchi, Kyung-Sun Kang and Oh-Kyeong Kweon
    Journal of Veterinary Science, 2008, 9(4), 387-393.
  7. Material design of bioabsorbable inorganic/organic composites for bone regeneration
    Takakuda K, Koyama Y, Matsumoto HN, Shirahama N, Akita K, Shoji D, Ogawa T, Kikuchi M and Tanaka J
    J Nanosci. & Nanotech., 2007, 7(3), 738-741.
  8. Reconstruction of bone fenestration on mandiblar by the guided bone regeneration methods with beta-TCP/PLGC membranes
    Y. Koyama , M. Kikuchi , K. Edamura, K. Nagaoka, S. Tanaka S, J. Tanaka and K. Takakuda
    J Nanosci. & Nanotech., 2007, 7(3), 859-861.
  9. Guided bone regeneration with beta-tricalcium phosphate and poly L- lactide-co-glycolide-co-epsilon-caprolactone membrane in partial defects of canine humerus
    Taehoon Oh, Md. Mizanur Rahman , Ji-Hey Lim , Mi-Sun Park , Dae-Yong Kim , Jung-hee Yoon , Wan Hee Kim , Masanori Kikuchi , Junzo Tanaka, Yoshihisa Koyama and Oh-Kyeong Kweon
    J. Vet. Sci., 2006, 7(1), 73-77.
  10. Control of pore structure and mechanical property in hydroxyapatite/collagen composite using unidirectional ice growth
    S. Yunoki, T. Ikoma, A. Monkawa, K. Ohta, M. Kikuchi, S. Sotome, K. Shinomiya and J. Tanaka
    Mater Let., 2006, 60(8), 999-1002.
  11. Bone Repair Analysis in a Novel Biodegradable Hydroxyapatite/Collagen Composite Implanted in Bone
    T. Nishikaw, K. Masuno, K. Tominaga,Y. KoyamY, T. YamadT, K. TakakudK, M. Kikuchi, J. Tanaka and A. Tanaka
    Implant Dent., 2005, 14(3), 252-260.
  12. Hydroxyapatite. Collagen (HAp/Col) Composite for Medical Use
    S. Itoh, M. Kikuchi, Y. Koyama, H. N. Matsumoto, K. Takakuda, K. Shinomiya, J. Tanaka
    Bio-Med. Mater. Eng, 2005, 15(1-2), 29-41.
  13. Development of a Hydroxyapatite/Collagen (HAp/Col) Nano-Composite as a Medical Device: The Effect of Cross-Linking to the HAp/Col Implant
    S. Itoh, M.Kikuchi, Y. Koyama, K. Takakuda, K. Shinomiya, J. Tanaka
    Cell Transplant., 2004, 13, 451-61.
  14. Synthesis and in vivo evaluation of a novel Hydroxyapatite/Collagen-alginate as bone filler and a drug delivery carrier of bone morphogenetic protein
    S. Sotome, T. Uemura, M. Kikuchi, C. Jiani, S. Itoh, J. Tanaka, T. Tateishi, K. Shinomiya
    Materials Science and Engineering: C, 2004, 24(3), 341-347.
  15. Development of Guided Bone Regeneration Membrane composed of b-tricalcium phosphate and poly (L-lactide -co- glycolide-co- e-caprolactone) composites
    M. Kikuchi, Y. Koyama, T.Yamada, Y. Imamura, T. Okada, N. Shirahama, K. Akita, K. Takakuda, J. Tanaka
    Biomaterials, 2004, 25, 5979-5986.
  16. Glutaraldehyde cross-linked hydroxyapatite/Collagen Self-Organized Nanocomposites
    M, Kikuchi, H. N. Matsumoto, T. Yamada, Y. Koyama, K. Takakuda and J. Tanaka
    Biomaterials, 2004, 25, 63-69.
  17. Control of pore structure and mechanical property in hydroxyapatite/collagen composite using unidirectional ice growth
    M. Kikuchi, Y. Koyama, K. Takakuda, H. Miyairi, N. Shirahama, and J. Tanaka
    J. Biomed. Mater. Res., 2002, 62(2), 265-272.
  18. Implantation study of a novel hydroxyapatite/collagen (HAp/col) composite into weight-bearing sites of dogs
    Itoh S, Kikuchi M, Takakuda K, Nagaoka K, Koyama Y, Tanaka J, Shinomiya K.
    J. Biomed. Mater. Res., 2002, 63(5), 507-515.
  19. Self-Organization Mechanism in a Bone-like Hydroxyapatite / Collagen Nanocomposite Synthesized in vitro and Its Biological Reaction in vivo
    M. Kikuchi, S. Itoh, S. Ichinose, K. Shinomiya and J. Tanaka
    Biomaterials, 2001, 22, 1705-1711.
    The paper is awarded as top 1% cited paper in the field of biomaterials from 2000-2004. Time cited at present is 292 in Web of Science.