The 322nd MANA Special Seminar
Prof. Wei-Bor Tsai & Prof. Yung Chang
| Date | March 18, Monday |
| Time | 13:30-15:30 |
| Place | Auditorium, 1F, WPI - MANA Building, Namiki Site, NIMS |
Download PDF file for seminar info.
13:30-14:30
Modulation of cell behavior by surface topography
In this talk, I would like to share our recent progresses on the mechanical properties of individual nanostructures by using direct in situ transmission electron microscopy (TEM), with particular considerations on the role of imperfections.
With WS 2 nanotubes as a model structure, the tensile properties and fracture processes were directly investigated. Surprisingly, it was found that the imperfect thick WS2 nanotubes could bear much higher loadings than the thin WS2 nanotubes with almost “defect-free” structures studied previously. HRTEM characterizations and real time observations revealed that the anomalous tensile properties are related to the inter-shell crosslinking and geometric constraints; these resulted in the multishell loading and fracturing.
Speaker
Prof. Wei-Bor Tsai, National Taiwan University, Taiwan
Chair
Dr. Guoping Chen, MANA PI, MANA, NIMS
14:30-15:30
Molecular Design and Development of Zwitterionic Biomaterials for Advanced Biomedical Applications
Intelligent biocompatible polymers can represent diverse forms, which might be dissolved as unimers or micelles in an aqueous medium, adsorbed or grafted on aqueous-solid interfaces, or cross-linked in the form of physical or chemical hydrogels. These polymers can undergo large physical chain conformation changes to small environmental stimuli of physical, chemical, or biochemical nature. Blood compatibility of biomimetic cellular structure is highly recommended for blood contacting materials in important biomedical applications, such as antithrombogenic implants, hemodialysis membranes, and biosensors. A new class of functional biopolymers is the biomimetic materials containing zwitterionic phosphatidylcholine (PC) headgroups for resisting nonspecific protein adsorption. Recently, synthetic polymers containing zwitterionic structures similar to PC, such as phosphobetaine, sulfobetaine, and carboxybetaine, have received growing attention for use in a new generation of blood-contacting materials because of their good plasma protein-fouling resistance. This talk will cover (1) bio-inert nature of biomimetic zwitterionic/pseudozwitterionic structures, (2) blood-inert surfaces via ion-pair anchoring of zwitterionic copolymer brushes in human whole blood, and (3) surface zwitterionization in novel biomedical applications.
Speaker
Prof. Yung Chang, Chung Yuan Christian University, Taiwan
Chair
Dr. Guoping Chen, MANA PI, MANA, NIMS