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Cellular Functional Nanobiomaterials Group

We study the interactions between nanomaterials and cells at molecular level. These interactions are very important for development of safe and functional biomaterials. Our goal is development of safe and functional nanobiomaterials using biotechnology.


In our group, we focus on the interactions between cells and nanobiomaterials including nanoparticles and nanostructures. We study how these nanostructure affect to the cellular functions and growth, and we will show the mechanism at molecular level.

"Schematic diagram for the interactions between nanobiomaterials and cells." Image

Schematic diagram for the interactions between nanobiomaterials and cells.

Selected Recent Results

1) Nishida, Y., Taniguchi, A. (2016) A three-dimensional collagen-sponge-based culture system coated with simplified recombinant fibronectin improves the function of a hepatocyte cell line. In Vitro – Animal, 52, 271-277.
2) T Y Tamaki, K Otsu H Harada, S Shibata, N Obara, K Irie, A Taniguchi, T Nagasawa, K Aoki, S R. Caliari, D W. Weisgerber, B A. C. Harley (2015) CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche. Cell Tissue Res., 362, 633-642.
3) Shimaa Abdellatef, Riho Tange, Takeshi Sato, Akihiko Ohi, Toshihide Nabatame and Akiyoshi Taniguchi. (2015) Nanostructures control the hepatocellular responses to a cytotoxic agent “cisplatin” BioMed Res. Int., 2015, 295319.
4) El-Said SK, Mostafa E, Kanehira K, Taniguchi A (2015) Comparison of oxidative stresses mediated by different crystalline forms and surface modification of titanium dioxide nanoparticles. J. Nanomaterials 2015, 8, http://dx.doi.org/10.1155/2015/703632.
5) El-Said SK, Mostafa E, Kanehira K, Taniguchi A (2014) Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines. J. Nanobiotech. 12, 48.
6) Romanazzo S, Forte G, Morishima K, Akiyoshi Taniguchi A. (2015) IL-12 Involvement in Myogenic Differentiation of C2C12 in vitro Biomat. Sci. 3, 469-479.
7) Mosqueira D, Pagliari S, Uto K, Ebara M, Romanazzo S, Escobedo-Lucea C, Nakanishi J, Taniguchi A, Franzese O, Di Nardo P, Goumans MJ, Traversa E, Pinto-do-Ó P, Aoyagi T, Forte G (2014) Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure. ACS Nano. 8, :2033-2047. doi: 10.1021/nn4058984.
8) Abdellatef S, Ohi A, Nabatame T, Taniguchi, A (2014) The Effect of Physical and Chemical Cues on Hepatocellular Function and Morphology Int. J. Mol. Sci. 15, 4299-4317; doi:10.3390/ijms15034299
9) T. Naganuma, E. Traversa “Air aqueous and thermal stability of Ce3+ ions in cerium oxide nanoparticle layers with substrates” Nanoscale 6 [12] (2014) 6637-6645.
10) T. Naganuma, E. Traversa “The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation” Biomaterials 35 [15] (2014) 4441-4453.
11) T. Naganuma, E. Traversa “Stability of Ce3+ valence state in cerium oxide nanoparticle layers” Nanoscale 4 [16] (2012) 4950-4953. 

Group Leader, Prof.

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Cellular Functional Nanobiomaterials Group
1-1 Namiki, Tsukuba, Ibaraki, 305-0044 JAPAN