Bioceramics Group

2023.04.01 Update


  • Synthesis and preparation of novel functional artificial bone materials based upon calcium phosphate ceramics.
  • Creation of novel high-functional materials utilizing microstructures of biominerals.
  • Research on interaction between materials and biomolecules/cells/tissues towards development of new biofunctional materials and their evaluation methods.
  • Development of Novel physical/chemical/biological test methods for biomaterials toward new ISO standards.

A porous artifi cial bone (Left: Already commercialized) and a self-setting bone paste (Right) in which hydroxyapatite and collagen have a bone-like nanostructure.


  • Chemical compositions and nanostructure of materials induce appropriate reaction from cells and higher structures such as interconnected pores affect viability and carrying of cells.
  • We are preparing hydroxyapatite and other calcium phosphates; and their composites with biopolymers and synthetic polymers. Further, we are optimizing their nano to micro scale structures to depelop novel bone regeneration materials and prostheses for hard tissues.
  • In addition, we are utilizing biomineral microstructures, which still cannot be mimicked artifi cially, to create novel and high functional materials for artifi cial bone and environment cleanup.
  • Further, on developments of evaluation/test methods, we are working on
    • Electrochemical measurement of Mg alloys in the presence of living cells under cell culture condition.
    • Development of an in vitro evaluation methods for pulmonary toxicity of nano/micro materials by simulating environment inside the human lung.
    • Investigation of the effects of pore structure on cell/tissue penetration behavior into metal foam.
    • Investigation of methods for extraction of nucleic acids under presence of hydroxyapatite nanocrystals.

Removal of fluoride ion using water cleanup material prepared from sea urchin test, a marine waste. Fluoride ions removed less than 8 mg/L, the emission standard of Japan.

Evaluation of osteosarcoma cell penetration into metal foam. Fluorescent microscopic observation revealed cell penetration distance from the top surface into the bottom depends on pore structures of the metal foam.

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Bioceramics Group
1-1 Namiki, Tsukuba, Ibaraki, 305-0044 JAPAN