Creation of novel materials for tissue regeneration as next generation medical technology
Tissue regeneration materials unit aims to create novel functional materials and innovative advanced technologies to meet the scaffolds, drug delivery and cell function manipulation requirements for ensuring regeneration of tissues that are lost or damaged due to diseases and traumas, through methods adopted in materials science and nanotechnology. Methods including hybridization, micro-patterning and biomimetics are used as key technologies to conduct basic and generic research on materials and scaffolds that can induce efficient tissue regeneration. The research will contribute to the promotion of regenerative medicine, improvement of quality of life and realization of a society with a long healthy life span.
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Specialized Research Field
Tissue regeneration materials group is devoted to the research and development of scaffolds that are required for regeneration of lost or damaged tissues due to diseases and traumas, and biomaterials to manipulate cell functions. Porous scaffolds and hybrid scaffolds of biodegradable synthetic polymers and naturally derived polymers, highly biocompatible scaffolds with nano- and microstructures constructed from cultured cells are designed and prepared. Biomaterials that mimic the in vivo nano- and microenvironment surrounding cells, and micro-patterned surfaces are also created to manipulate cell functions, especially stem cell functions.
1. Development of hybrid porous scaffolds for tissue engineering
2. Preparation of biomimetic scaffolds
Funnel-like collagen sponge
Cultured cells-derived ECM scaffold
3. Manipulation of cell functions by patterned materials
Manipulation of cell shape of single stem cell by micro-patterned surface (green: cytoskeleton, blue: nucleus)
